Results 171 to 180 of about 6,483 (202)

Interaction of beta‐blockers with the renal uptake transporter OCT2

Diabetes, Obesity and Metabolism, 2009
Aim: The uptake of drugs from the blood into the renal tubular cells is a key determinant for renal secretion and may influence their systemic plasma concentrations and extrarenal effects. Metformin, used for treatment of type 2 diabetes, is taken up into renal tubular cells by the organic cation transporter 2 ...
I, Bachmakov, H, Glaeser, B, Endress, F, Mörl, J, König, M F, Fromm   +5 more
openaire   +2 more sources

Novel method for kinetic analysis applied to transport by the uniporter OCT2

American Journal of Physiology-Renal Physiology, 2022
Here, we describe a mathematical model that uses the time course of net substrate uptake into cells from several increasing concentrations to calculate unique kinetic parameters [maximal rates of transport ( Jmax) and half-saturation constants ( Kt)] of the process.
Stephen H. Wright, Timothy W. Secomb
openaire   +2 more sources

Fampridine is a Substrate and Inhibitor of Human OCT2, but not of Human MATE1, or MATE2K

Pharmaceutical Research, 2018
The renal clearance of fampridine (Fampyra®, or Ampyra®) significantly exceeds the glomerular filtration rate, suggesting active renal secretion is likely the major elimination pathway. The goal of this study was to identify the renal transporters that are involved in the renal active secretion, and elucidate the active renal secretion mechanism of ...
Guangqing Xiao, Christopher Rowbottom, Carri Boiselle, Liang-Shang Gan   +3 more
openaire   +2 more sources

Effect of 7-ketocholesterol incorporation on substrate binding affinity and turnover rate of the organic cation transporter 2 (OCT2) [PDF]

Biochemical Pharmacology
The organic cation transporter 2 (OCT2) is pivotal in the renal elimination of several positively charged molecules. OCT2 mode of transport is profoundly influenced by the level of membrane cholesterol. The aim of this study was to investigate the effect
Lara Console, Cesare Indiveri, Michele Visentin   +2 more
exaly   +2 more sources

OCT2 – The next generation

Optician, 2016
Bill Harvey tries out the new OCT2 module, the software platform upgrade that positions the Spectralis ready for the very latest developments in OCT use in practice.
openaire   +1 more source

Localization of organic cation transporters OCT1 and OCT2 in rat kidney

American Journal of Physiology-Renal Physiology, 2000
Renal excretion and reabsorption of organic cations are mediated by electrogenic and electroneutral organic cation transporters, which belong to a recently discovered family of polyspecific transporters. These transporters are electrogenic and exhibit differences in substrate specificity.
U, Karbach, J, Kricke, F, Meyer-Wentrup, V, Gorboulev, C, Volk, D, Loffing-Cueni, B, Kaissling, S, Bachmann, H, Koepsell   +8 more
openaire   +2 more sources

Analysis of Oct2‐Isoform Expression in Lipopolysaccharide‐Stimulated B Lymphocytes

Scandinavian Journal of Immunology, 1994
Oct2‐isoform expression in splenic B cells stimulated with lipopolysaccharide or lipopolysaccharide plus phorbol‐di‐butyrate was analysed by cDNA cloning. The frequency of Oct2‐positivc clones was 1/15, 000 in both libraries. Two new isoforms were found that generate novel amino‐ or carboxy‐terminal sequences.
K, Johansson, M, Sigvardsson, T, Leanderson   +2 more
openaire   +2 more sources

In vitro interaction of clopidogrel and its hydrolysate with OCT1, OCT2 and OAT1

International Journal of Pharmaceutics, 2014
Clopidogrel (CP) is metabolized by CYPs to the active metabolite, or hydrolyzed by esterase to clopidogrel carboxylate (CPC) in liver, and CPC is partly excreted from urine. Therefore, the objective of the present study was to evaluate the interactions of CP and CPC with organic cation transporter 1 (OCT1) (in liver), and CPC with organic cation ...
Liping, Li, Feifeng, Song, Meijuan, Tu, Kai, Wang, Lei, Zhao, Xiaodan, Wu, Hui, Zhou, Zongling, Xia, Huidi, Jiang   +8 more
openaire   +2 more sources

A Note on Oct1+-Minor-Free Graphs and Oct2+-Minor-Free Graphs

Journal of Interconnection Networks, 2022
Let [Formula: see text] and [Formula: see text] be the planar and non-planar graphs, respectively, obtained from the Octahedron by 3-splitting a vertex. For [Formula: see text], we prove that if a 4-connected graph is [Formula: see text]-minor-free, then it is [Formula: see text], [Formula: see text] [Formula: see text] or it is obtained from [Formula:
Wenyan Jia, Shuai Kou, Weihua Yang, Chengfu Qin   +3 more
openaire   +1 more source

Tear Meniscus Height Determination Using the OCT2 and the RTVue‐100

Optometry and Vision Science, 2009
ABSTRACT Purpose. To compare anterior segment spectral‐domain optical coherence tomography (SOCT) tear meniscus height (TMH) measures with those from the more commonly used time‐domain OCT (TOCT). Methods.
Adam, Keech, John, Flanagan, Trefford, Simpson, Lyndon, Jones   +3 more
openaire   +2 more sources