Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine. [PDF]
PLoS ONE, 2017 Ranitidine (Zantac®) is a H2-receptor antagonist commonly used for the treatment of acid-related gastrointestinal diseases. Ranitidine was reported to be a substrate of the organic cation transporters OCT1 and OCT2. The hepatic transporter OCT1 is highly
Marleen Julia Meyer +3 more
doaj +6 more sources
Regulation of OCT2 transcriptional repression by histone acetylation in renal cell carcinoma [PDF]
Epigenetics, 2019 Renal cell carcinoma (RCC) is a common malignant tumour affecting the urinary system, and multidrug resistance is one of the major reasons why chemotherapy for this type of cancer often fails.
Qianying Zhu +6 more
doaj +5 more sources
Characterization of ligand-induced thermal stability of the human organic cation transporter 2 (OCT2) [PDF]
Frontiers in Pharmacology, 2023 Introduction: The human organic cation transporter 2 (OCT2) is involved in the transport of endogenous quaternary amines and positively charged drugs across the basolateral membrane of proximal tubular cells.
Max Maane +5 more
doaj +4 more sources
Pharmacogenetics meets metabolomics: discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition. [PDF]
PLoS ONE, 2012 Genetic polymorphisms of the organic cation transporter 2 (OCT2), encoded by SLC22A2, have been investigated in association with metformin disposition.
Im-Sook Song +10 more
doaj +2 more sources
Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity [PDF]
Clinical Pharmacology & Therapeutics, 2009 Cisplatin is one of the most widely used anticancer agents for the treatment of solid tumors. The clinical use of cisplatin is associated with dose-limiting nephrotoxicity, which occurs in one-third of patients despite intensive prophylactic measures. Organic cation transporter 2 (OCT2) has been implicated in the cellular uptake of cisplatin, but its ...
Filipski, K K +4 more
core +7 more sources
Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates. [PDF]
PLoS ONE, 2015 The importance of the organic cation transporter OCT2 in the renal excretion of cationic drugs raises the possibility of drug-drug interactions (DDIs) in which an inhibitor (perpetrator) drug decreases OCT2-dependent renal clearance of a victim ...
Kristina Hacker +4 more
doaj +3 more sources
Biomedicines, 2023 Metformin plasma exposure is increased in rats with thioacetamide (TAA)-induced liver failure. The absorption, distribution, and excretion process of metformin is mainly mediated by organic cation transporters (OCTs) and multidrug and toxin extrusion ...
Hao Zhi +9 more
doaj +2 more sources
Cells, 2022 Despite potent anticancer activity, the clinical utilization of cisplatin is limited due to nephrotoxicity. As Organic Cation Transporter 2 (OCT2) has been shown to be one of the key transporters involved in the uptake of cisplatin into renal proximal ...
Hardik Mody +3 more
doaj +2 more sources
Oct2 and Obf1 as facilitators of B:T cell collaboration during a humoral immune response [PDF]
Frontiers in Immunology, 2014 The Oct2 protein, encoded by the Pou2f2 gene, was originally predicted to act as a DNA binding transcriptional activator of immunoglobulin (Ig) in B lineage cells.
Lynn M Corcoran +6 more
doaj +2 more sources
The OCT2/MATE1 Interaction Between Trifluridine, Metformin and Cimetidine: A Crossover Pharmacokinetic Study [PDF]
Clinical PharmacokineticsTrifluridine/tipiracil, registered for the treatment of patients with metastatic gastric and colorectal cancer, is a substrate and inhibitor for the organic cation transporter 2 (OCT2) and the multidrug and toxin extrusion protein 1 (MATE1), which raises the potential for drug-drug interactions with other OCT2/MATE1 modulators.
Niels A. D. Guchelaar +15 more
openaire +4 more sources