Results 31 to 40 of about 6,483 (202)
Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2 [PDF]
Proceedings of the National Academy of Sciences, 2013 Oxaliplatin is an integral component of colorectal cancer therapy, but its clinical use is associated with a dose-limiting peripheral neurotoxicity. We found that the organic cation transporter 2 (OCT2) is expressed on dorsal root ganglia cells within the nervous system where oxaliplatin is known to accumulate.
Sprowl, J +9 more
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Egyptian Journal of Medical Human Genetics, 2023 Background Organic cation transporter 2 (OCT2) is a renal carrier transporter protein found in the basolateral membrane of proximal epithelial cells, which facilitates active secretion of Metformin.
Swathi Swaroopa Borra +6 more
doaj +1 more source
Nucleic Acids Research, 1994 The lymphocyte specific transcription factor Oct2 is involved in mediating the B-cell specific transcriptional activity of the octamer motif. Mutational analyses in the context of the complete Oct2 protein had indicated that Oct2 contains two transactivation domains.
A, Annweiler, S, Zwilling, T, Wirth
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Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons. [PDF]
PLoS ONE, 2007 BACKGROUND: The etiology of neurodegenerative disorders, such as the accelerated loss of dopaminergic neurons in Parkinson's disease, is unclear. Current hypotheses suggest an abnormal function of the neuronal sodium-dependent dopamine transporter DAT to
Dirk Taubert +3 more
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Cisplatin-Induced Renal Injury Is Independently Mediated by OCT2 and p53 [PDF]
Clinical Cancer Research, 2014 Abstract Purpose: Tubular secretion of cisplatin is abolished in mice deficient for the organic cation transporters Oct1 and Oct2 (Oct1/2−/−mice), and these animals are protected from severe cisplatin-induced kidney damage. Since tubular necrosis is not completely absent in Oct1/2−/−mice, we hypothesized that alternate pathways are ...
Jason A, Sprowl +11 more
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Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells
, 2022 MATE1 (multidrug and toxin extruder 1) and OCT2 (organic cation transporter 2) play critical roles in organic cation excretion by the human kidney. The transporter turnover rate (TOR) is relevant to understanding both their transport mechanisms and ...
Wright, S.H. +3 more
core +1 more source
Transport of biguanides by human organic cation transporter OCT2
Biomedicine & Pharmacotherapy, 2013 Biguanides have the severe side effect of lactic acidosis. Although both metformin and phenformin are biguanide derivatives, there is a difference in the frequency at which they induce lactic acidosis. However, the reasons for the difference are not clear.
Yoshihisa, Sogame +4 more
openaire +2 more sources
The association of transporter genes polymorphisms and lung cancer chemotherapy response. [PDF]
PLoS ONE, 2014 Lung cancer is one of the most common cancers and is the leading cause of death worldwide. Platinum-based chemotherapy is the main treatment method in lung cancer patients.
Ying Wang +9 more
doaj +1 more source
In Vitro and In Vivo Inhibition of MATE1 by Tyrosine Kinase Inhibitors
Pharmaceutics, 2021 The membrane transport of many cationic prescription drugs depends on facilitated transport by organic cation transporters of which several members, including OCT2 (SLC22A2), are sensitive to inhibition by select tyrosine kinase inhibitors (TKIs).
Muhammad Erfan Uddin +8 more
doaj +1 more source
Scientific Reports, 2018 Trimethylamine-N-oxide (TMAO) gained considerable attention because of its role as a cardiovascular risk biomarker. Organic cation transporter 2 (OCT2) mediates TMAO uptake into renal proximal tubular cells.
A. Gessner, J. König, M. F. Fromm
doaj +1 more source