Results 41 to 50 of about 6,483 (202)
PHARMACOGENETICS OF ORGANIC CATION TRANSPORTERS
Безопасность и риск фармакотерапии, 2018 This article describes basic information about the classification, structure, substrate specificity and expression of organic cation transporters. The pharmacokinetic and pharmacogenetic aspects of transporters are discussed in more detail, as well as ...
V. A. Evteev +3 more
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Frontiers in Physiology, 2022 p-Tyramine (TYR) is an endogenous trace amine, which can also be synthesized by intestinal microbiota, and is present in commonly consumed diets. TYR is an agonist for the intracellular trace amine-associated receptor 1, which has been implicated in ...
Shreyasi Sarkar +2 more
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Malaria Journal, 2017 Background Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse drug–drug interactions (DDIs).
Maarten van der Velden +7 more
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Role of OCT2 and MATE1 in renal disposition and toxicity of nitidine chloride [PDF]
British Journal of Pharmacology, 2016 Background and PurposeNitidine chloride (NC), a benzophenanthridine alkaloid, has various biological properties including anticancer and analgesic activities. The aim of the present study was to evaluate the role of organic cation transporter 2 (OCT2) and multidrug and toxin extrusion 1 (MATE1) in the renal disposition and nephrotoxicity of NC ...
L P, Li +8 more
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Pharmaceutics, 2021 Transmembrane transport of metformin is highly controlled by transporters including organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), and multidrug/toxin extrusions (MATEs).
Yiting Yang +5 more
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Journal of Radiation and Cancer Research, 2017 Uptake transporters are being studied for roles in the entry of therapeutic drugs into cells and thus can be exploited to improve the treatment of various diseases.
Dindial Ramotar
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CPT: Pharmacometrics & Systems Pharmacology, 2022 Pemigatinib is a potent inhibitor of fibroblast growth factor receptor being developed for oncology indications. It is primarily metabolized by cytochrome P450 (CYP) 3A4, and the ratio of estimated concentration over concentration required for 50 ...
Tao Ji, Xuejun Chen, Swamy Yeleswaram
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Gender differences in expression of organic cation transporter OCT2 in rat kidney [PDF]
FEBS Letters, 1999 The organic cation transporter (OCT) mediates translocation of various cationic molecules including drugs, toxins and endogenous substances. We examined gender differences in the expression of rat (r) OCT2 in the kidney. Slices and basolateral membrane vesicles of male rat kidney showed a higher transport activity for tetraethylammonium than those of ...
Urakami, Yumiko +6 more
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Substrates and Inhibitors of the Organic Cation Transporter 3 and Comparison with OCT1 and OCT2
Journal of Medicinal Chemistry, 2022 Organic cation transporters (OCTs) 1, 2, and 3 facilitate cellular uptake of structurally diverse endogenous and exogenous substances. However, their substrate and inhibitor specificity are not fully understood. We performed a broad in vitro screening for OCT3 substrates and inhibitors, allowing us to compare the substrate spectra and to study the ...
Lukas Gebauer +3 more
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Molecular Principles of Oct2-Mediated Gene Activation in B Cells
Immunobiology, 1995 The octamer motif is a crucial regulatory element for immunoglobulin promoter and enhancer function. We have investigated the molecular mechanisms that underlie octamer-mediated gene activation in B cells. This B cell-specific transcriptional regulation is subject to a novel type of regulatory mechanism.
T, Wirth +4 more
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