Results 61 to 70 of about 69,757 (296)

Nanotechnology approaches for ocular drug delivery

Middle East African Journal of Ophthalmology, 2013
Blindness is a major health concern worldwide that has a powerful impact on afflicted individuals and their families, and is associated with enormous socio-economical consequences. The Middle East is heavily impacted by blindness, and the problem there is augmented by an increasing incidence of diabetes in the population.
Xu, Qingguo, Kambhampati, Siva P., Kannan, Rangaramanujam M.   +2 more
openaire   +3 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Comprehensive Strategies for Overcoming Barriers in Ocular Drug Delivery: Current Trends and Future Directions

Biomedical Sciences and Clinical Medicine
The human eye is a complex and sensitive organ, making effective drug delivery a major challenge. Its anatomical barriers, such as the precorneal, corneal, and blood-ocular barriers, significantly limit drug penetration and retention.
Elavarasan N, S. Revathi, K. Venkateshwaran   +2 more
doaj   +1 more source

Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis [PDF]

, 2006
Galectin (Gal)-1, an endogenous lectin found at sites of immune privilege, plays a critical role in the regulation of the immune response. Therapeutic administration of Gal-1 or its genetic delivery suppresses chronic inflammation in experimental models ...
Bianco, German Ariel, Ferrero, Mercedes, Juarez, Claudio P., Luna, José Domingo, Muiño, Juan Carlos, Rabinovich, Gabriel A., Romero, Marta D.   +6 more
core   +1 more source

Nanoliposomal minocycline for ocular drug delivery [PDF]

Nanomedicine: Nanotechnology, Biology and Medicine, 2013
Nanoliposomal technology is a promising drug delivery system that could be employed to improve the pharmacokinetic properties of clearance and distribution in ocular drug delivery to the retina. We developed a nanoscale version of an anionic, cholesterol-fusing liposome that can encapsulate therapeutic levels of minocycline capable of drug delivery. We
James M, Kaiser, Hisanori, Imai, Jeremy K, Haakenson, Robert M, Brucklacher, Todd E, Fox, Sriram S, Shanmugavelandy, Kellee A, Unrath, Michelle M, Pedersen, Pingqi, Dai, Willard M, Freeman, Sarah K, Bronson, Thomas W, Gardner, Mark, Kester   +12 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Episcleral Venous Pressure and the Ocular Hypotensive Effects of Topical and Intracameral Prostaglandin Analogs. [PDF]

, 2019
There is a limit beyond which increasing either the concentration of a prostaglandin analog (PGA) or its dosing frequency fails to produce increases in ocular hypotensive efficacy with topical dosing.
Alm, Blondeau, Brubaker, Celebi, Chen, Cymbor, Eveleth, Foroozan, Friberg, Funk, Funk, Katz, Krieglstein, Lee, Lee, Lee, Lewis, Lindén, Lovering, McDougal, Nagasubramanian, Ogundele, Phelps, Prum, Seal, Selbach, Selbach, Sherwood, Sit, Sit, Strohmaier, Tsai, Walløe, Watts, Wilke, Zamora, Zamora   +36 more
core   +2 more sources

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Unraveling the Therapeutic Enigma of Liposomes in Ocular Drug Delivery

Journal of Bio-X Research
The ocular delivery of drugs has always presented a pharmaceutical challenge. Various ocular barriers, such as reflex blinking, tear turnover, epithelial tight junctions, metabolism in ocular tissues, efflux pumps, nasolacrimal drainage, and other blood ...
Sandip Karmakar, Sreejan Manna, Tamal Jana, Sougata Jana, Gouranga Nandi   +4 more
doaj   +1 more source

Computational Study of Hydrogel Ring Device for Ocular Drug Delivery [PDF]

, 2018
Researchers have developed many different kinds of ocular drug delivery devices. However, most address anterior eye disorders—very few are designed specifically for the treatment of posterior eye diseases.
Hanif, Sarah, Lim, Abigail, Sit, Hilarie, Tan, Wan Qing Melissa   +3 more
core