Results 1 to 10 of about 11,439 (266)

Chromatin Accessibility Predetermines Odontoblast Terminal Differentiation

Frontiers in Cell and Developmental Biology, 2021
Embryonic development and stem cell differentiation are orchestrated by changes in sequential binding of regulatory transcriptional factors to their motifs.
Qian Zhang, Zhen Huang, Huanyan Zuo, Yuxiu Lin, Yao Xiao, Yanan Yan, Yu Cui, Chujiao Lin, Fei Pei, Zhi Chen, Huan Liu, Huan Liu   +11 more
doaj   +2 more sources

Histological investigation of the effects of chitosan and 3 different pulpotomy agents on rat dental pulps [PDF]

BMC Oral Health
Background Pulpotomy is a vital pulp therapy performed following the removal of infected or affected coronal pulp. However, there is no consensus on the most effective pulpotomy agent.
Kübra Pedük, Salih Doğan, Nurhan Özalp, Kenan Cantekin, Esra Balcıoğlu, Özge Göktepe   +5 more
doaj   +2 more sources

MARCH2 suppresses odontoblast differentiation by polyubiquitinating PTPRD [PDF]

International Journal of Oral Science
Dentin, the main component of dental hard tissues, is produced by differentiated odontoblasts. How odontoblast differentiation is regulated remains understudied. Here, we screen that the expression of membrane-associated RING finger protein 2 (March2) is
Hao Feng, Jiaxin Niu, Zhi Chen, Guobin Yang, Guohua Yuan   +4 more
doaj   +2 more sources

Establishment of Dental Pulp Cell Culture System for Analyzing Dentinogenesis in Mouse Incisors [PDF]

Dentistry Journal
Background: The dentin–pulp complex plays a vital role in tooth health. Dentin forms the main body the tooth and continues to form throughout life to maintain homeostasis and provide protection against deleterious external stimuli.
Yuka Kato, Insoon Chang, Satoshi Yokose
doaj   +2 more sources

Inositol-requiring enzyme 1 alpha is essential for dentinogenesis [PDF]

Frontiers in Physiology
IntroductionInositol-requiring enzyme 1 alpha (IRE1α), encoded by endoplasmic reticulum (ER) to nucleus signaling 1 (Ern1) gene, is the most conserved sensor of ER stress.
Qian Xu, Qian Xu, Tian Liang, Tian Liang, Jiahe Li, Suzhen Wang, Hua Zhang, Julie Hollien, Takao Iwawaki, Chunlin Qin, Yongbo Lu   +10 more
doaj   +2 more sources

Odontoblast control of dental pulp inflammation triggered by cariogenic bacteria [PDF]

Frontiers in Physiology, 2013
Jean-Christophe eFarges, Jean-Christophe eFarges, Jean-Christophe eFarges, Brigitte eAlliot-licht, Caroline eBaudouin, Philippe eMsika, Françoise eBleicher, Florence eCarrouel, Florence eCarrouel   +8 more
doaj   +2 more sources

Pericytes Are Odontoblast Progenitor Cells Depending on ER Stress. [PDF]

J Dent Res
Ouchi T, Ando M, Kurashima R, Kimura M, Saito N, Iwasaki A, Sekiya H, Nakajima K, Hasegawa T, Mizoguchi T, Shibukawa Y.   +10 more
europepmc   +2 more sources

Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation

International Journal of Oral Science, 2023
The biomolecular mechanisms that regulate tooth root development and odontoblast differentiation are poorly understood. We found that Atp6i deficient mice (Atp6i −/− ) arrested tooth root formation, indicated by truncated Hertwig’s epithelial root sheath
Jue Wang, Abigail McVicar, Yilin Chen, Hong-Wen Deng, Zhihe Zhao, Wei Chen, Yi-Ping Li   +6 more
doaj   +1 more source

Role of connexin 43 in odontoblastic differentiation and structural maintenance in pulp damage repair

International Journal of Oral Science, 2021
Dental pulp can initiate its damage repair after an injury of the pulp–dentin complex by rearrangement of odontoblasts and formation of newly differentiated odontoblast-like cells.
Jiaxin Yin, Jue Xu, Ran Cheng, Meiying Shao, Yuandong Qin, Hui Yang, Tao Hu   +6 more
doaj   +1 more source

Increasing Odontoblast-like Differentiation from Dental Pulp Stem Cells through Increase of β-Catenin/p-GSK-3β Expression by Low-Frequency Electromagnetic Field

Biomedicines, 2021
Odontoblasts produce proteins that form the dentinal extracellular matrix, which can protect the dental pulp from external stimuli and is required for tooth regeneration.
Han-Moi Lim, Myeong-Hyun Nam, Yu-Mi Kim, Young-Kwon Seo   +3 more
doaj   +1 more source