Results 1 to 10 of about 15,982 (300)

Chromatin Accessibility Predetermines Odontoblast Terminal Differentiation

Frontiers in Cell and Developmental Biology, 2021
Embryonic development and stem cell differentiation are orchestrated by changes in sequential binding of regulatory transcriptional factors to their motifs.
Qian Zhang, Zhen Huang, Huanyan Zuo, Yuxiu Lin, Yao Xiao, Yanan Yan, Yu Cui, Chujiao Lin, Fei Pei, Zhi Chen, Huan Liu, Huan Liu   +11 more
doaj   +2 more sources

Human odontoblast-like cells produce nitric oxide with antibacterial activity upon TLR2 activation [PDF]

Frontiers in Physiology, 2015
The penetration of cariogenic oral bacteria into enamel and dentin during the caries process triggers an immune/inflammatory response in the underlying pulp tissue, the reduction of which is considered a prerequisite to dentinogenesis-based pulp ...
Jean-Christophe eFARGES, Jean-Christophe eFARGES, Jean-Christophe eFARGES, Jean-Christophe eFARGES, Aurélie eBellanger, Maxime eDucret, Maxime eDucret, Maxime eDucret, Elisabeth eAubert-Foucher, Beatrice eRichard, Beatrice eRichard, Beatrice eRichard, Brigitte eAlliot-licht, Françoise eBleicher, Florence eCarrouel, Florence eCarrouel   +15 more
doaj   +3 more sources

Mitochondrial DNA leakage exacerbates odontoblast inflammation through gasdermin D-mediated pyroptosis

Cell Death Discovery, 2021
Alleviating odontoblast inflammation is crucial to control the progression of pulpitis. Mitochondrial DNA (mtDNA) is a vital driver of inflammation when it leaks from mitochondria of inflamed odontoblasts into the cytosol.
Yi-Fei Zhang, Lu Zhou, Han-Qing Mao, Fu-Hua Yang, Zhi Chen, Lu Zhang   +5 more
doaj   +2 more sources

HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation

Frontiers in Cell and Developmental Biology, 2020
Odontoblast differentiation is an important process during tooth development in which pre-odontoblasts undergo elongation, polarization, and finally become mature secretory odontoblasts.
Yunyan Zhan, Haisheng Wang, Lu Zhang, Fei Pei, Zhi Chen   +4 more
doaj   +2 more sources

Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization

Frontiers in Physiology, 2021
Odontoblasts play critical roles in dentin formation and sensory transduction following stimuli on the dentin surface. Exogenous stimuli to the dentin surface elicit dentinal sensitivity through the movement of fluids in dentinal tubules, resulting in ...
Mayumi Matsunaga, Mayumi Matsunaga, Maki Kimura, Takehito Ouchi, Takashi Nakamura, Sadao Ohyama, Masayuki Ando, Sachie Nomura, Toshifumi Azuma, Tatsuya Ichinohe, Yoshiyuki Shibukawa   +10 more
doaj   +2 more sources

Establishment of Dental Pulp Cell Culture System for Analyzing Dentinogenesis in Mouse Incisors [PDF]

Dentistry Journal
Background: The dentin–pulp complex plays a vital role in tooth health. Dentin forms the main body the tooth and continues to form throughout life to maintain homeostasis and provide protection against deleterious external stimuli.
Yuka Kato, Insoon Chang, Satoshi Yokose
doaj   +2 more sources

Identification of dentinogenic cell-specific surface antigens in odontoblast-like cells derived from adult dental pulp

Stem Cell Research & Therapy, 2019
Background Odontoblast is a unique progenitor that plays a role in dentin formation. So far, the dentinogenic differentiation of dental pulp stem cells and the role of surface molecules of odontoblasts in dentinogenesis are not well known yet.
Kyung-Jung Kang, Chun-Jeih Ryu, Young-Joo Jang   +2 more
doaj   +2 more sources

Intercellular odontoblast communication via ATP mediated by pannexin-1 channel and phospholipase C-coupled receptor activation.

Frontiers in Physiology, 2015
Extracellular ATP released via pannexin-1 channels, in response to the activation of mechanosensitive-TRP channels during odontoblast mechanical stimulation, mediates intercellular communication among odontoblasts in dental pulp slice preparation ...
Masaki eSato, Tadashi eFuruya, Tadashi eFuruya, Maki eKimura, Yuki eKojima, Masakazu eTazaki, Toru eSato, Yoshiyuki eShibukawa   +7 more
doaj   +2 more sources

LincRNA-ASAO promotes dental pulp repair through interacting with PTBP1 to increase ALPL alternative splicing [PDF]

Stem Cell Research & Therapy
Background Alternative splicing not only expands the genetic encoding of genes but also determines cellular activities. This study aimed to elucidate the regulation mechanism and biological functions of lincRNA-ASAO in the process of odontogenesis ...
Fuchun Fang, Xiaolan Guo, Sitong Liu, Longrui Dang, Zehao Chen, Yumeng Yang, Lu Chen, Jiahao Lin, Wei Qiu, Zhao Chen, Buling Wu   +10 more
doaj   +2 more sources

Novel Roles of Nestin in Postnatal Root Formation [PDF]

Dentistry Journal
Background/Objectives: Nestin is an intermediate filament protein and a marker of odontoblasts, but its function in tooth and bone formation is largely unknown.
Yan Jing, Jinqiu Wu, Ying Liu, Xiaohua Liu, Chi Ma   +4 more
doaj   +2 more sources