Results 1 to 10 of about 9,972 (218)

MARCH2 suppresses odontoblast differentiation by polyubiquitinating PTPRD [PDF]

International Journal of Oral Science
Dentin, the main component of dental hard tissues, is produced by differentiated odontoblasts. How odontoblast differentiation is regulated remains understudied. Here, we screen that the expression of membrane-associated RING finger protein 2 (March2) is
Hao Feng, Jiaxin Niu, Zhi Chen, Guobin Yang, Guohua Yuan   +4 more
doaj   +2 more sources

Histological investigation of the effects of chitosan and 3 different pulpotomy agents on rat dental pulps [PDF]

BMC Oral Health
Background Pulpotomy is a vital pulp therapy performed following the removal of infected or affected coronal pulp. However, there is no consensus on the most effective pulpotomy agent.
Kübra Pedük, Salih Doğan, Nurhan Özalp, Kenan Cantekin, Esra Balcıoğlu, Özge Göktepe   +5 more
doaj   +2 more sources

Establishment of Dental Pulp Cell Culture System for Analyzing Dentinogenesis in Mouse Incisors [PDF]

Dentistry Journal
Background: The dentin–pulp complex plays a vital role in tooth health. Dentin forms the main body the tooth and continues to form throughout life to maintain homeostasis and provide protection against deleterious external stimuli.
Yuka Kato, Insoon Chang, Satoshi Yokose
doaj   +2 more sources

Chromatin Accessibility Predetermines Odontoblast Terminal Differentiation

Frontiers in Cell and Developmental Biology, 2021
Embryonic development and stem cell differentiation are orchestrated by changes in sequential binding of regulatory transcriptional factors to their motifs.
Qian Zhang, Zhen Huang, Huanyan Zuo, Yuxiu Lin, Yao Xiao, Yanan Yan, Yu Cui, Chujiao Lin, Fei Pei, Zhi Chen, Huan Liu, Huan Liu   +11 more
doaj   +1 more source

Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation

International Journal of Oral Science, 2023
The biomolecular mechanisms that regulate tooth root development and odontoblast differentiation are poorly understood. We found that Atp6i deficient mice (Atp6i −/− ) arrested tooth root formation, indicated by truncated Hertwig’s epithelial root sheath
Jue Wang, Abigail McVicar, Yilin Chen, Hong-Wen Deng, Zhihe Zhao, Wei Chen, Yi-Ping Li   +6 more
doaj   +1 more source

Role of connexin 43 in odontoblastic differentiation and structural maintenance in pulp damage repair

International Journal of Oral Science, 2021
Dental pulp can initiate its damage repair after an injury of the pulp–dentin complex by rearrangement of odontoblasts and formation of newly differentiated odontoblast-like cells.
Jiaxin Yin, Jue Xu, Ran Cheng, Meiying Shao, Yuandong Qin, Hui Yang, Tao Hu   +6 more
doaj   +1 more source

Effect of angiopoietin 4 on odontogenic differentiation of dental pulp stem cells

口腔疾病防治, 2023
Objective To investigate the effects of angiopoietin 4 (ANGPT4) on the odontogenic differentiation of human dental pulp stem cells. Methods This study has been reviewed and approved by the Ethics Committee, and informed consent has been obtained from ...
FAN Xinyi, LIU Cangwei , ZHOU Yijun , REN Feilong, SHI Ce, SUN Hongchen   +5 more
doaj   +1 more source

Laminin-Modified Dental Pulp Extracellular Matrix for Dental Pulp Regeneration

Frontiers in Bioengineering and Biotechnology, 2021
Native dental pulp extracellular matrix (DPEM) has proven to be an effective biomaterial for dental pulp regeneration. However, as a significant extracellular matrix glycoprotein, partial laminins were lost during the decellularization process, which ...
Jiahui Fu, Jianfeng Chen, Wenjun Li, Xiaomin Yang, Jingyan Yang, Huixin Quan, Haitao Huang, Gang Chen, Gang Chen   +8 more
doaj   +1 more source

HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation

Frontiers in Cell and Developmental Biology, 2020
Odontoblast differentiation is an important process during tooth development in which pre-odontoblasts undergo elongation, polarization, and finally become mature secretory odontoblasts.
Yunyan Zhan, Haisheng Wang, Lu Zhang, Fei Pei, Zhi Chen   +4 more
doaj   +1 more source

Matrix metalloproteinase-3 in odontoblastic cells derived from ips cells: unique proliferation response as odontoblastic cells derived from ES cells. [PDF]

PLoS ONE, 2013
We previously reported that matrix metalloproteinase (MMP)-3 accelerates wound healing following dental pulp injury. In addition, we reported that a proinflammatory cytokine mixture (tumor necrosis factor-α, interleukin (IL)-1β and interferon-γ) induced ...
Taiki Hiyama, Nobuaki Ozeki, Makio Mogi, Hideyuki Yamaguchi, Rie Kawai, Kazuhiko Nakata, Ayami Kondo, Hiroshi Nakamura   +7 more
doaj   +1 more source