Results 11 to 20 of about 11,439 (266)

Mitochondrial DNA leakage exacerbates odontoblast inflammation through gasdermin D-mediated pyroptosis

Cell Death Discovery, 2021
Alleviating odontoblast inflammation is crucial to control the progression of pulpitis. Mitochondrial DNA (mtDNA) is a vital driver of inflammation when it leaks from mitochondria of inflamed odontoblasts into the cytosol.
Yi-Fei Zhang, Lu Zhou, Han-Qing Mao, Fu-Hua Yang, Zhi Chen, Lu Zhang   +5 more
doaj   +2 more sources

HDAC6 Regulates the Fusion of Autophagosome and Lysosome to Involve in Odontoblast Differentiation

Frontiers in Cell and Developmental Biology, 2020
Odontoblast differentiation is an important process during tooth development in which pre-odontoblasts undergo elongation, polarization, and finally become mature secretory odontoblasts.
Yunyan Zhan, Haisheng Wang, Lu Zhang, Fei Pei, Zhi Chen   +4 more
doaj   +2 more sources

Identification of dentinogenic cell-specific surface antigens in odontoblast-like cells derived from adult dental pulp

Stem Cell Research & Therapy, 2019
Background Odontoblast is a unique progenitor that plays a role in dentin formation. So far, the dentinogenic differentiation of dental pulp stem cells and the role of surface molecules of odontoblasts in dentinogenesis are not well known yet.
Kyung-Jung Kang, Chun-Jeih Ryu, Young-Joo Jang   +2 more
doaj   +2 more sources

Hypoxia-inducible factor 1α induces osteo/odontoblast differentiation of human dental pulp stem cells via Wnt/β-catenin transcriptional cofactor BCL9

Scientific Reports, 2022
Accelerated dental pulp mineralization is a common complication in avulsed/luxated teeth, although the mechanisms underlying this remain unclear. We hypothesized that hypoxia due to vascular severance may induce osteo/odontoblast differentiation of ...
Shion Orikasa, Nobuyuki Kawashima, Kento Tazawa, Kentaro Hashimoto, Keisuke Sunada-Nara, Sonoko Noda, Mayuko Fujii, Tetsu Akiyama, Takashi Okiji   +8 more
doaj   +2 more sources

Odontoblast TRPC5 channels signal cold pain in teeth [PDF]

Science Advances, 2021
The odontoblast, with processes beyond the dentin-enamel boundary, is the initial site of TRPC5 cold transduction in teeth. Teeth are composed of many tissues, covered by an inflexible and obdurate enamel.
Laura Bernal, Pamela Sotelo-Hitschfeld, Christine König, Viktor Sinica, Amanda Wyatt, Zoltán Winter, Alexander Hein, Filip Touška, Susanne Reinhardt, Aaron Tragl, Ricardo Kusuda, Philipp Wartenberg, Allen Sclaroff, John D. Pfeifer, Fabien Ectors, Andreas Dahl, Marc Freichel, Viktorie Vlachová, Sebastián Brauchi, Carolina Roza, Ulrich Boehm, David E. Clapham, Jochen K. Lennerz, Katharina Zimmermann   +23 more
openalex   +2 more sources

Intercellular odontoblast communication via ATP mediated by pannexin-1 channel and phospholipase C-coupled receptor activation.

Frontiers in Physiology, 2015
Extracellular ATP released via pannexin-1 channels, in response to the activation of mechanosensitive-TRP channels during odontoblast mechanical stimulation, mediates intercellular communication among odontoblasts in dental pulp slice preparation ...
Masaki eSato, Tadashi eFuruya, Tadashi eFuruya, Maki eKimura, Yuki eKojima, Masakazu eTazaki, Toru eSato, Yoshiyuki eShibukawa   +7 more
doaj   +2 more sources

Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway [PDF]

Cell Communication and Signaling, 2021
Mitochondrial DNA (mtDNA) is a vital driver of inflammation when it leaks from damaged mitochondria into the cytosol. mtDNA stress may contribute to cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway activation in infectious ...
Lu Zhou, Yi-Fei Zhang, Fuhua Yang, Hanqing Mao, Zhi Chen, Lu Zhang   +5 more
openalex   +2 more sources

Human odontoblast-like cells produce nitric oxide with antibacterial activity upon TLR2 activation

Frontiers in Physiology, 2015
The penetration of cariogenic oral bacteria into enamel and dentin during the caries process triggers an immune/inflammatory response in the underlying pulp tissue, the reduction of which is considered a prerequisite to dentinogenesis-based pulp ...
Jean-Christophe eFARGES, Jean-Christophe eFARGES, Jean-Christophe eFARGES, Jean-Christophe eFARGES, Aurélie eBellanger, Maxime eDucret, Maxime eDucret, Maxime eDucret, Elisabeth eAubert-Foucher, Beatrice eRichard, Beatrice eRichard, Beatrice eRichard, Brigitte eAlliot-licht, Françoise eBleicher, Florence eCarrouel, Florence eCarrouel   +15 more
doaj   +2 more sources

Gαs-Coupled CGRP Receptor Signaling Axis from the Trigeminal Ganglion Neuron to Odontoblast Negatively Regulates Dentin Mineralization

Biomolecules, 2022
An inflammatory response following dental pulp injury and/or infection often leads to neurogenic inflammation via the axon reflex. However, the detailed mechanism underlying the occurrence of the axon reflex in the dental pulp remains unclear.
Natsuki Saito, M. Kimura, T. Ouchi, T. Ichinohe, Y. Shibukawa   +4 more
semanticscholar   +1 more source

Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization

Frontiers in Physiology, 2021
Odontoblasts play critical roles in dentin formation and sensory transduction following stimuli on the dentin surface. Exogenous stimuli to the dentin surface elicit dentinal sensitivity through the movement of fluids in dentinal tubules, resulting in ...
M. Matsunaga, M. Kimura, T. Ouchi, Takashi Nakamura, Sadao Ohyama, M. Ando, Sachi Nomura, T. Azuma, T. Ichinohe, Y. Shibukawa   +9 more
semanticscholar   +1 more source