Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase [PDF]
, 2012 Cilia of olfactory sensory neurons are the primary sensory organelles for olfaction. The detection of odorants by the main olfactory epithelium (MOE) depends on coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia.
Chen, Xuanmao +2 more
core +2 more sources
Characterisation of Bombyx mori odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components [PDF]
, 2009 In many insect species, odorant-binding proteins (OBPs) are thought to be responsible for the transport of pheromones and other semiochemicals across the sensillum lymph to the olfactory receptors (ORs) within the antennal sensilla.
Adams +79 more
core +1 more source
The narrowing olfactory landscape of insect odorant receptors
Frontiers in Ecology and Evolution, 2015 The molecular basis of odorant detection and its corollary, the task of the odorant receptor, are fundamental to understanding olfactory coding and sensory ecology.
Jonathan Daniel Bohbot +1 more
doaj +1 more source
Short-term memory trace mediated by termination kinetics of olfactory receptor. [PDF]
, 2016 Odorants activate receptors in the peripheral olfactory neurons, which sends information to higher brain centers where behavioral valence is determined.
Boyle, Sean Michael +3 more
core +1 more source
Odorant Receptor 7D4 Activation Dynamics [PDF]
Angewandte Chemie, 2018 AbstractDeciphering how an odorant activates an odorant receptor (OR) and how changes in specific OR residues affect its responsiveness are central to understanding our sense of smell. A joint approach combining site‐directed mutagenesis and functional assays with computational modeling has been used to explore the signaling mechanics of OR7D4. In this
Claire A. de March +6 more
openaire +3 more sources
Identification of odorant-receptor interactions by global mapping of the human odorome.
PLoS ONE, 2014 The human olfactory system recognizes a broad spectrum of odorants using approximately 400 different olfactory receptors (hORs). Although significant improvements of heterologous expression systems used to study interactions between ORs and odorant ...
Karine Audouze +7 more
doaj +1 more source
Characterization of an enantioselective odorant receptor in the yellow fever mosquito Aedes aegypti. [PDF]
PLoS ONE, 2009 Enantiomers differ only in the left or right handedness (chirality) of their orientations and exhibit identical chemical and physical properties. In chemical communication systems, enantiomers can be differentially active at the physiological and ...
Jonathan D Bohbot, Joseph C Dickens
doaj +1 more source
Expanding the olfactory code by in silico decoding of odor-receptor chemical space
eLife, 2013 Coding of information in the peripheral olfactory system depends on two fundamental factors: interaction of individual odors with subsets of the odorant receptor repertoire and mode of signaling that an individual receptor-odor interaction elicits ...
Sean Michael Boyle +2 more
doaj +1 more source
Olfactory receptor antagonism between odorants [PDF]
The EMBO Journal, 2003 The detection of thousands of volatile odorants is mediated by several hundreds of different G protein-coupled olfactory receptors (ORs). The main strategy in encoding odorant identities is a combinatorial receptor code scheme in that different odorants are recognized by different sets of ORs.
Oka, Yuki +3 more
openaire +3 more sources
Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb [PDF]
, 2007 The formation of precise stereotypic connections in sensory systems is critical for the ability to detect and process signals from the environment. In the olfactory system, olfactory sensory neurons (OSNs) project axons to spatially defined glomeruli ...
Andrews, W +4 more
core +1 more source