Results 101 to 110 of about 2,759,679 (292)
Off-target effects of carfilzomib that cause cardiotoxicity [PDF]
Blood, 2019 In this issue of Blood, Efentakis et al report using an animal model to study carfilzomib (Cfz)–induced cardiotoxicity and to demonstrate that the molecular mechanism is not related to the inhibition of the proteasome function but instead has an influence on modulation of the autophagy pathway, inactivation of AMPKα, and upregulation of PP2A ...
openaire +2 more sources
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda +15 more
wiley +1 more source
Achieving Plant CRISPR Targeting that Limits Off‐Target Effects
The Plant Genome, 2016 The CRISPR‐Cas9 system (clustered regularly interspaced short palindromic repeats with associated Cas9 protein) has been used to generate targeted changes for direct modification of endogenous genes in an increasing number of plant species; but development of plant genome editing has not yet fully considered ...
Jeffrey D. Wolt +3 more
openaire +3 more sources
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Heavy Flavour production as probe of Gluon Sivers Function
, 2016 Heavy flavour production like $J/\psi$ and $D$- meson production in scattering of electrons/unpolarized protons off polarized proton target offer promising probes to investigate gluon Sivers function.
Godbole, Rohini M. +4 more
core +1 more source
Artificial escape from XCI by DNA methylation editing of the CDKL5 gene. [PDF]
, 2020 A significant number of X-linked genes escape from X chromosome inactivation and are associated with a distinct epigenetic signature. One epigenetic modification that strongly correlates with X-escape is reduced DNA methylation in promoter regions. Here,
Anderson, Johnathon D +14 more
core +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Shadowing, Binding and Off-Shell Effects in Nuclear Deep Inelastic Scattering
, 1994 We present a unified description of nuclear deep inelastic scattering (DIS) over the whole region ...
A. C. Benvenuti +59 more
core +2 more sources