Results 241 to 250 of about 2,759,679 (292)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Taming the Achilles' Heel: A Chemical and Structural Design to Address Off-Target Effects in siRNA Therapeutics. [PDF]

JACS Au
Parvathaneni RP, Krishnan N, Hempel N, Oommen OP, Varghese OP.   +4 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A therapeutic antisense oligonucleotide encompassing 2'-<i>O</i>-methoxyethyl modification triggers unique perturbation of the transcriptome. [PDF]

NAR Mol Med
Ottesen EW, Murzyn WA, Kaas RL, Bertrand KJ, Payne JL, Singh RN.   +5 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Contingency discrimination training and resurgence: Effects of reduced extinction session durations. [PDF]

J Exp Anal Behav
Shahan TA, Hiltz JB, Avellaneda M, Greer BD.   +3 more
europepmc   +1 more source

2'-Ribose-modified nucleotides: A strategy for reducing off-target effects of oligonucleotide drugs. [PDF]

Mol Ther Nucleic Acids
Zhang H, Liu Y, Ma J, Huang H, Zhang W, Xiu D, Ma T, Zhang M, Yu F, Song G.   +9 more
europepmc   +1 more source

Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect?

J Allergy Clin Immunol, 2014
Birrell MA, Bonvini SJ, Dubuis E, Maher SA, Wortley MA, Grace MS, Raemdonck K, Adcock JJ, Belvisi MG.   +8 more
europepmc   +1 more source

Comprehensive profiling of CRISPR/dCas9 epigenome editors indicates a complex link between on and off target effects. [PDF]

Genome Biol
Pahlevan Kakhki M, Rangani F, Ewing E, Starvaggi Cucuzza C, Zheleznyakova G, Kalomoiri M, Kenny L, Raghavan A, Rao Prakash C, van den Hoeven G, Venkata S Badam T, Covacu R, Andreou I, Needhamsen M, Kular L, Jagodic M.   +15 more
europepmc   +1 more source