Results 1 to 10 of about 11,328 (158)

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction [PDF]

PLoS ONE, 2012
Oxidative damage to DNA is mainly repaired via base excision repair, a pathway that is catalyzed by DNA glycosylases such as 8-oxoguanine DNA glycosylase (OGG1). While OGG1 has been implicated in maintaining genomic integrity and preventing tumorigenesis,
Harini Sampath, Yusaku Nakabeppu, R Stephen Lloyd   +2 more
exaly   +2 more sources

OGG1 Preserves Endothelial-Dependent Vasodilation and Regulates the Frequency and Spatial Area of Endothelial Calcium Signals [PDF]

Biomolecules
Endothelial calcium dysregulation underlies impairments in endothelial-dependent vasodilation (EDV), contributing to vascular disease progression. Repletion of 8-oxoguanine DNA glycosylase (OGG1), an enzyme involved in base excision repair, has been ...
Takreem Aziz, Larysa Yuzefovych, Lyudmila Rachek, Mark S. Taylor, Christopher M. Francis   +4 more
doaj   +2 more sources

Molecular Duality of OGG1: From Genomic Guardian to Redox-Sensitive Modulator in Diseases [PDF]

Antioxidants
Inflammation, malignant tumors, and age-related disorders are all associated with oxidative DNA damage. 8-oxoguanine DNA glycosylase 1 (OGG1), which recognizes and repairs intracellular oxidative damage, was initially thought to play a pivotal role in ...
Ranwei Zhong, Weiran Zhang, Xiangping Qu, Yang Xiang, Ming Ji   +4 more
doaj   +2 more sources

DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognition [PDF]

Cellular and Molecular Life Sciences
Base excision repair, initiated by DNA glycosylases, preserves genomic integrity by removing damaged bases. DNA glycosylases Ogg1 and Mutyh were shown to alter the hippocampal transcriptome independently of DNA damage repair.
Andreas Abentung, Teri Sakshaug, Rabina Dumaru, Nina-Beate Liabakk, Mingyi Yang, Junbai Wang, Magnar Bjørås, Katja Scheffler   +7 more
doaj   +2 more sources

Oxidatively damaged DNA in DNA repair-deficient and ethanol-exposed fetal brains induces gene dysregulation and mitochondrial dysfunction associated with neurodevelopmental disorders [PDF]

Redox Biology
Oxidatively damaged DNA caused by reactive oxygen species (ROS) in the fetal brain contributes to neurodevelopmental disorders (NDDs), but the mechanism is unclear.
Ashley P. Cheng, Piriththiv Dhavarasa, Jana van Heeswyk, Sophia M. Richards, Xuan Li, Aaron M. Shapiro, Peter G. Wells   +6 more
doaj   +2 more sources

Oxidative Stress Regulates CDH3 Expression in Lung Cancer Cells via OGG1-Mediated SP1 Binding [PDF]

Antioxidants
Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, plays a crucial role in tumor development.
Ying Ma, Jiarong Guo, Shichu Xu, Yanjun Hou, Feiyan Pan, Zhigang Guo   +5 more
doaj   +2 more sources

Association of base excision repair pathway genes OGG1 , XRCC1 and MUTYH polymorphisms and the level of 8-oxo-guanine with increased risk of colorectal cancer occurrence

International Journal of Occupational Medicine and Environmental Health, 2022
Objectives Reduced efficiency of DNA repair systems has long been a suspected factor in increasing the risk of cancer. In this work authors investigate influence of selected polymorphisms of DNA repair genes ( XRCC1 , OGG1 and MUTYH ) and level of ...
Jacek Kabziński, Ireneusz Majsterek
doaj   +1 more source

Functional characterization of 8-oxoguanine DNA glycosylase of Trypanosoma cruzi [PDF]

, 2012
The oxidative lesion 8-oxoguanine (8-oxoG) is removed during base excision repair by the 8-oxoguanine DNA glycosylase 1 (Ogg1). This lesion can erroneously pair with adenine, and the excision of this damaged base by Ogg1 enables the insertion of a ...
Campos, PC, de Moura, MB, Franco, GR, Furtado, C, Kunrath-Lima, M, Macedo, AM, Machado, CR, Mendes, IC, Pena, SDJ, Rajão, MA, Teixeira, SMR, van Houten, B   +11 more
core   +7 more sources

OGG1 Inhibitor TH5487 Alters OGG1 Chromatin Dynamics and Prevents Incisions

Biomolecules, 2020
8-oxoguanine DNA glycosylase (OGG1) is the main DNA glycosylase responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG) from duplex DNA to initiate base excision repair.
Bishoy M. F. Hanna, Thomas Helleday, Oliver Mortusewicz   +2 more
doaj   +1 more source

The E3 Ubiquitin Ligase NEDD4L Targets OGG1 for Ubiquitylation and Modulates the Cellular DNA Damage Response

Frontiers in Cell and Developmental Biology, 2020
8-Oxoguanine DNA glycosylase (OGG1) is the major cellular enzyme required for the excision of 8-oxoguanine DNA base lesions in DNA through the base excision repair (BER) pathway, and therefore plays a major role in suppressing mutagenesis and in ...
Jonathan R. Hughes, Jason L. Parsons, Jason L. Parsons   +2 more
doaj   +1 more source