Results 11 to 20 of about 11,397 (216)

OGG1 in Lung—More than Base Excision Repair

Antioxidants, 2022
As the organ executing gas exchange and directly facing the external environment, the lungs are challenged continuously by various stimuli, causing the disequilibration of redox homeostasis and leading to pulmonary diseases.
Xiaodi Ma, Hewei Ming, Lexin Liu, Jiahui Zhu, Lang Pan, Yu Chen, Yang Xiang   +6 more
doaj   +3 more sources

NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487 [PDF]

International Journal of Molecular Sciences, 2021
DNA damage caused by reactive oxygen species may result in genetic mutations or cell death. Base excision repair (BER) is the major pathway that repairs DNA oxidative damage in order to maintain genomic integrity. In mammals, eleven DNA glycosylases have been reported to initiate BER, where each recognizes a few related DNA substrate lesions with some ...
Bishoy M. F. Hanna, Maurice Michel, Thomas Helleday, Oliver Mortusewicz   +3 more
openaire   +4 more sources

OGG1 in the Kidney: Beyond Base Excision Repair

Oxidative Medicine and Cellular Longevity, 2022
8‐Oxoguanine DNA glycosylase (OGG1) is a repair protein for 8‐oxoguanine (8‐oxoG) in eukaryotic atopic DNA. Through the initial base excision repair (BER) pathway, 8‐oxoG is recognized and excised, and subsequently, other proteins are recruited to complete the repair. OGG1 is primarily located in the cytoplasm and can enter the nucleus and mitochondria
Fan Zhao, Jiefu Zhu, Lang Shi, Xiongfei Wu   +3 more
openaire   +3 more sources

PLAGL1 overexpression exacerbates type 1 diabetes by inducing β-cell apoptosis via oxidative stress-dependent dual DNA damage and cGAS/STING pathway activation. [PDF]

J Diabetes Investig
ABSTRACT Background Type 1 diabetes mellitus (T1DM) arises from autoimmune destruction of pancreatic β‐cells. Pleomorphic adenoma gene‐like 1 (PLAGL1) overexpression has been linked to β‐cell apoptosis, but molecular mechanisms remain incompletely understood.
Li C, Qiao L, Ge J, Hu S, Yang H, Hu C, Li T.   +6 more
europepmc   +2 more sources

OGG1 inhibition suppresses African swine fever virus replication

Virologica Sinica, 2023
African swine fever virus (ASFV) is an important pathogen that causes a highly contagious and lethal disease in swine, for which neither a vaccine nor treatment is available. The DNA repair enzyme 8-oxoguanine DNA glycosylase 1 (OGG1), which excises the oxidative base lesion 8-oxo-7,8-dihydroguanine (8-oxoG), has been linked to the pathogenesis of ...
Jie Fan, Xinqian Lv, Saixia Yang, Shuxian Geng, Jifei Yang, Yaru Zhao, Zhonghui Zhang, Zhijie Liu, Guiquan Guan, Jianxun Luo, Qiaoying Zeng, Hong Yin, Qingli Niu   +12 more
openaire   +2 more sources

OGG1Polymorphisms and Breast Cancer Risk [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2006
AbstractThe role of oxidative stress in breast cancer risk is still unclear. OGG1 encodes an 8-oxoguanine DNA glycosylase/AP lyase that catalyzes the removal of 8-oxodeoxyguanosine from DNA. 8-Oxodeoxyguanosine, the most abundant lesion generated by oxidative stress, is highly mutagenic.
Pavel, Rossner, Mary Beth, Terry, Marilie D, Gammon, Fang Fang, Zhang, Susan L, Teitelbaum, Sybil M, Eng, Sharon K, Sagiv, Mia M, Gaudet, Alfred I, Neugut, Regina M, Santella   +9 more
openaire   +2 more sources

8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization [PDF]

, 2014
Reactive oxygen species (ROS) are activators of cell signaling and modify cellular molecules, including DNA. 8-Oxo-7,8-dihydroguanine (8-oxoG) is one of the prominent lesions in oxidatively damaged DNA, whose accumulation is causally linked to various ...
Ba, Xueqing, Boldogh, István, Brasier, Allan R., Bácsi, Attila, Hazra, Tapas K., Hegde, Muralidhar L., Hosoki, Koa, Luo, Jixian, Radak, Zsolt, Sur, Sanjiv   +9 more
core   +4 more sources

Innate Immune Responses to RSV Infection Facilitated by OGG1, an Enzyme Repairing Oxidatively Modified DNA Base Lesions

Journal of Innate Immunity, 2022
The primary cause of morbidity and mortality from infection with respiratory syncytial virus (RSV) is the excessive innate immune response(s) (IIR) in which reactive oxygen species (ROS) play key role(s).
Xu Zheng, Ke Wang, Lang Pan, Wenjing Hao, Yaoyao Xue, Attila Bacsi, Spiros A. Vlahopoulos, Zsolt Radak, Tapas K. Hazra, Allan R. Brasier, Lloyd Tanner, Xueqing Ba, Istvan Boldogh   +12 more
doaj   +1 more source

Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

Frontiers in Immunology, 2020
Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease in which type I interferons (IFN) play a key role. The IFN response can be triggered when oxidized DNA engages the cytosolic DNA sensing platform cGAS-STING, but the repair ...
Gantsetseg Tumurkhuu, Gantsetseg Tumurkhuu, Gantsetseg Tumurkhuu, Shuang Chen, Shuang Chen, Shuang Chen, Erica N. Montano, Erica N. Montano, Duygu Ercan Laguna, Duygu Ercan Laguna, Gabriela De Los Santos, Gabriela De Los Santos, Jeong Min Yu, Malcolm Lane, Michifumi Yamashita, Janet L. Markman, Luz P. Blanco, Mariana J. Kaplan, Kenichi Shimada, Kenichi Shimada, Kenichi Shimada, Timothy R. Crother, Timothy R. Crother, Timothy R. Crother, Mariko Ishimori, Mariko Ishimori, Daniel J. Wallace, Daniel J. Wallace, Caroline A. Jefferies, Caroline A. Jefferies, Moshe Arditi, Moshe Arditi, Moshe Arditi   +32 more
doaj   +1 more source

Altered Epigenetic Marks and Gene Expression in Fetal Brain, and Postnatal Behavioural Disorders, Following Prenatal Exposure of Ogg1 Knockout Mice to Saline or Ethanol

Cells, 2023
Oxoguanine glycosylase 1 (OGG1) is widely known to repair the reactive oxygen species (ROS)-initiated DNA lesion 8-oxoguanine (8-oxoG), and more recently was shown to act as an epigenetic modifier.
Shama Bhatia, David Bodenstein, Ashley P. Cheng, Peter G. Wells   +3 more
doaj   +1 more source