The Role of 8-Oxoguanine DNA Glycosylase-1 in Inflammation [PDF]
, 2017 Many, if not all, environmental pollutants/chemicals and infectious agents increase intracellular levels of reactive oxygen species (ROS) at the site of exposure.
Aguilera-Aguirre, Leopoldo +8 more
core +4 more sources
Long-term pulmonary complications in sulfur mustard-exposed patients: gene expression and DNA methylation of OGG1 [PDF]
BioImpactsIntroduction: It is well established that tissues exposed to sulfur mustard (SM) generate high levels of reactive oxygen species. This leads to oxidative stress and, ultimately, damage to DNA molecules over the course of time.
Mohammad Saber Zamani, Tooba Ghazanfari
doaj +1 more source
A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients. [PDF]
, 2015 BACKGROUND: Personalized therapy considering clinical and genetic patient characteristics will further improve breast cancer survival. Two widely used treatments, chemotherapy and radiotherapy, can induce oxidative DNA damage and, if not repaired, cell ...
Aittomäki, Kristiina +44 more
core +4 more sources
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis [PDF]
DNA Repair, 2018 Mitochondrial DNA (mtDNA) resides in close proximity to metabolic reactions, and is maintained by the 8-oxoguanine DNA glycosylase (Ogg1) and other members of the base excision repair pathway. Here, we tested the hypothesis that changes in liver metabolism as under fasting/feeding conditions would be sensed by liver mtDNA, and that Ogg1 deficient mice ...
Scheffler, Katja +8 more
openaire +4 more sources
PLoS ONE, 2020 OGG1-deficient (Ogg1-/-) animals display increased propensity to age-induced and diet-induced metabolic diseases, including insulin resistance and fatty liver.
Holly Simon +6 more
doaj +1 more source
Conditional Targeting of the DNA Repair Enzyme hOGG1 into Mitochondria [PDF]
, 2002 Oxidative damage to mitochondrial DNA (mtDNA) has been suggested to be a key factor in the etiologies of many diseases and in the normal process of aging.
Grishko, Valentina I. +5 more
core +1 more source
Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis [PDF]
International Journal of Molecular Sciences, 2017 The role of deficiency of oxoguanine glycosylase 1 (Ogg1) Mmh homolog, a repair enzyme of the 8-hydroxy-2’-deoxyguanosine (8-OHdG) residue in DNA, was investigated using the multiorgan carcinogenesis bioassay in mice. A total of 80 male and female six-week-old mice of C57BL/6J background carrying a mutant Mmh allele of the Mmh/Ogg1 gene (Ogg1−/−) and ...
Kakehashi, Anna +5 more
openaire +2 more sources
Frontiers in Immunology, 2023 Interferons (IFNs) are secreted cytokines with the ability to activate expression of IFN stimulated genes that increase resistance of cells to virus infections.
Yaoyao Xue +13 more
doaj +1 more source
Carcinogenicity of dimethylarsinic acid in Ogg1‐deficient mice [PDF]
Cancer Science, 2007 Oxidative stress to DNA is recognized as a mechanism underlying carcinogenic effects of some environmental agents. Here, we hypothesized that dimethylarsinic acid (DMAV), an organic metabolite of inorganic arsenic in humans, might exert carcinogenic potential in a mouse line carrying a mutant Mmh allele of the Mmh/OGG1 gene encoding the enzyme 8 ...
Anna, Kinoshita +9 more
openaire +2 more sources
Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair [PDF]
, 2013 Single-strand break repair (SSBR) and base excision repair (BER) of modified bases and abasic sites share several players. Among them is XRCC1, an essential scaffold protein with no enzymatic activity, required for the coordination of both pathways ...
Amouroux +61 more
core +4 more sources