Results 111 to 120 of about 244,975 (377)

Voltage-gated currents in identified rat olfactory receptor neurons

Journal of Neuroscience, 1991
Whole-cell recording techniques were used to characterize voltage-gated membrane currents in neonatal rat olfactory receptor neurons (ORNs) in cell culture.
P. Trombley, G. Westbrook
semanticscholar   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Functional olfactory sensory neurons housed in olfactory sensilla on the ovipositor of the hawkmoth Manduca sexta.

Frontiers in Ecology and Evolution, 2016
Olfactory systems evolved to detect and identify volatile chemical cues, in many cases across great distances. However, the precision of copulatory and oviposition behaviors suggest that they may be guided by olfactory cues detected by sensory systems ...
Christian Felix Klinner, Christopher König, Christine Missbach, Achim Werckenthin, Kevin Charles Daly, Sonja Bisch-Knaden, Monika Stengl, Bill S. Hansson, Ewald Große-Wilde   +8 more
doaj   +1 more source

Patch-clamp studies of isolated mouse olfactory receptor neurons

The Journal of General Physiology, 1987
Olfactory receptor neurons isolated from embryonic, neonatal, and adult mice were studied using the patch-clamp technique. Several distinct types of ion channels were characterized in patches of membrane from the neuronal soma and the dendritic knob of ...
R. Maue, V. E. Dionne
semanticscholar   +1 more source

SARS-CoV-2 receptor and entry genes are expressed by sustentacular cells in the human olfactory neuroepithelium

bioRxiv, 2020
Various reports indicate an association between COVID-19 and anosmia, suggesting an infection of the olfactory sensory epithelium, and thus a possible direct virus access to the brain.
Leon Fodoulian, Joël Tuberosa, D. Rossier, Madlaina Boillat, Chenda Kan, Véronique Pauli, K. Egervari, J. Lobrinus, B. Landis, A. Carleton, I. Rodriguez   +10 more
semanticscholar   +1 more source

A Review on Biodegradable Materials of Sustainable Soft Robotics and Electronics

Advanced Science, EarlyView.
Biodegradable materials are gaining increasing attention in soft robotics and electronics due to their environmental friendliness, showing great potential for sustainability. In this review, the classification of biodegradable materials, their applications in the field of soft robotics and electronics, as well as the challenges and future prospects ...
Yizhu Xie, Jiaxin Han, Xingyi Dai, Xuyang Zhang, Kangwen Xiao, Junhui Huang, Yajun Cao, Aihua Zhong, Long‐Biao Huang   +8 more
wiley   +1 more source

The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

eLife, 2012
We have identified a replication-independent histone variant, Hist2h2be (referred to herein as H2be), which is expressed exclusively by olfactory chemosensory neurons. Levels of H2BE are heterogeneous among olfactory neurons, but stereotyped according to
Stephen W Santoro, Catherine Dulac
doaj   +1 more source

Short-term memory trace mediated by termination kinetics of olfactory receptor. [PDF]

, 2016
Odorants activate receptors in the peripheral olfactory neurons, which sends information to higher brain centers where behavioral valence is determined.
Boyle, Sean Michael, McInally, Shane, Ray, Anandasankar, Tharadra, Sana   +3 more
core   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Intensity Coding in Two-Dimensional Excitable Neural Networks

, 2004
In the light of recent experimental findings that gap junctions are essential for low level intensity detection in the sensory periphery, the Greenberg-Hastings cellular automaton is employed to model the response of a two-dimensional sensory network to ...
Bair, Bardou, Bokil, Chialvo, Cleland, Copelli, Deans, Firestein, Greenberg, Hidaka, Kaplan, Kosaka, Lewis, Mauro Copelli, Osame Kinouchi, Purves, Rospars, Simões-de-Souza, Stevens, Tomé, Traub, Wiener, Zhang, Zorzenon dos Santos   +23 more
core   +2 more sources