Results 21 to 30 of about 53,380 (165)
Olfactory Receptor Neuron Dysfunction in Schizophrenia [PDF]
Neuropsychopharmacology, 2008 Olfactory impairments are a common feature of schizophrenia. Impairments in odor detection and odor identification are present early in the course of illness and among those at risk for the disorder. These behavioral impairments have been linked to both physiological and anatomical abnormalities in the neural substrates subserving olfaction, including ...
Bruce I, Turetsky +3 more
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Cell Reports, 2020 Summary: Olfactory neurons allow animals to discriminate nutritious food sources from potential pathogens. From a forward genetic screen, we uncovered a surprising requirement for the olfactory neuron gene olrn-1 in the regulation of intestinal ...
Kyle J. Foster +5 more
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Olfactory deficits in an alpha-synuclein fly model of Parkinson's disease. [PDF]
PLoS ONE, 2014 Parkinson's disease (PD) is the most common motor neurodegenerative disorder. Olfactory dysfunction is a prevalent feature of PD. It often precedes motor symptoms by several years and is used in assisting PD diagnosis. However, the cellular and molecular
Alex Y Chen +3 more
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Olfactory Receptor Neuron Profiling using Sandalwood Odorants [PDF]
Chemical Senses, 2004 The mammalian olfactory system can discriminate between volatile molecules with subtle differences in their molecular structures. Efforts in synthetic chemistry have delivered a myriad of smelling compounds of different qualities as well as many molecules with very similar olfactive properties. One important class of molecules in the fragrance industry
Stephan, Bieri +2 more
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An update on anatomy and function of the teleost olfactory system [PDF]
PeerJ, 2019 About half of all extant vertebrates are teleost fishes. Although our knowledge about anatomy and function of their olfactory systems still lags behind that of mammals, recent advances in cellular and molecular biology have provided us with a wealth of ...
Jesús Olivares, Oliver Schmachtenberg
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The source of spontaneous activity in the main olfactory bulb of the rat. [PDF]
PLoS ONE, 2011 In vivo, most neurons in the main olfactory bulb exhibit robust spontaneous activity. This paper tests the hypothesis that spontaneous activity in olfactory receptor neurons drives much of the spontaneous activity in mitral and tufted cells via ...
Josif Stakic +3 more
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Expressing exogenous functional odorant receptors in cultured olfactory sensory neurons
Neural Development, 2008 Background Olfactory discrimination depends on the large numbers of odorant receptor genes and differential ligand-receptor signaling among neurons expressing different receptors.
Fomina Alla F +3 more
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Advantage of the Highly Restricted Odorant Receptor Expression Pattern in Chemosensory Neurons of Drosophila. [PDF]
PLoS ONE, 2013 A fundamental molecular feature of olfactory systems is that individual neurons express only one receptor from a large odorant receptor gene family. While numerous theories have been proposed, the functional significance and evolutionary advantage of ...
Sana Khalid Tharadra +2 more
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Signal Amplification in Drosophila Olfactory Receptor Neurons [PDF]
Neuron, 2019 Olfactory receptor neurons (ORNs) transform scant chemical inputs into significant neural signals. This transformation requires signal amplification. In this issue of Neuron, Ng et al. (2019) identified a mechanism by which the signals evoked by pheromones are amplified in the ORNs that selectively promote courtship behavior in Drosophila.
Byoung Soo, Kim, Greg S B, Suh
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Signaling by olfactory receptor neurons near threshold [PDF]
Proceedings of the National Academy of Sciences, 2010 An important contributing factor for the high sensitivity of sensory systems is the exquisite sensitivity of the sensory receptor cells. We report here the signaling threshold of the olfactory receptor neuron (ORN). We first obtained a best estimate of the size of the physiological electrical response successfully triggered by a single odorant-binding ...
Vikas, Bhandawat +2 more
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