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Mechanosensitivity of Human Oligodendrocytes [PDF]

open access: yesFrontiers in Cellular Neuroscience, 2020
Oligodendrocytes produce and repair myelin, which is critical for the integrity and function of the central nervous system (CNS). Oligodendrocyte and oligodendrocyte progenitor cell (OPC) biology is modulated in vitro by mechanical cues within the ...
Daniela Espinosa-Hoyos   +10 more
doaj   +4 more sources

Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination

open access: yeseLife, 2023
In the developing central nervous system, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes, which form myelin around axons. Oligodendrocytes and myelin are essential for the function of the central nervous system, as evidenced ...
Lin Pan   +7 more
doaj   +1 more source

Pathogenetic Mechanisms Underlying Spinocerebellar Ataxia Type 3 Are Altered in Primary Oligodendrocyte Culture

open access: yesCells, 2022
Emerging evidence has implicated non-neuronal cells, particularly oligodendrocytes, in the pathophysiology of many neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease and ...
Kristen H. Schuster   +2 more
doaj   +1 more source

Oligodendrocyte precursor cell maturation: role of adenosine receptors

open access: yesNeural Regeneration Research, 2021
Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and their degeneration leads to demyelinating diseases such as multiple sclerosis.
Federica Cherchi   +2 more
doaj   +1 more source

Serum Anti-oligodendrocyte Autoantibodies in Patients With Multiple Sclerosis Detected by a Tissue-Based Immunofluorescence Assay

open access: yesFrontiers in Neurology, 2021
Multiple sclerosis (MS), the most prevalent inflammatory disease of the central nervous system (CNS), is characterized by damaged to myelin sheaths and oligodendrocytes.
Yukino Miyachi   +15 more
doaj   +1 more source

High Yield of Adult Oligodendrocyte Lineage Cells Obtained from Meningeal Biopsy

open access: yesFrontiers in Pharmacology, 2017
Oligodendrocyte loss can lead to cognitive and motor deficits. Current remyelinating therapeutic strategies imply either modulation of endogenous oligodendrocyte precursors or transplantation of in vitro expanded oligodendrocytes.
Sissi Dolci   +15 more
doaj   +1 more source

H3K9ac and HDAC2 Activity Are Involved in the Expression of Monocarboxylate Transporter 1 in Oligodendrocyte

open access: yesFrontiers in Molecular Neuroscience, 2017
Recently, it is reported that monocarboxylate transporter 1 (MCT1) plays crucial role in oligodendrocyte differentiation and myelination. We found that MCT1 is strongly expressed in oligodendrocyte but weakly expressed in oligodendrocyte precursors (OPCs)
Qingwei Lai   +12 more
doaj   +1 more source

PBAF Subunit Pbrm1 Selectively Influences the Transition from Progenitors to Pre-Myelinating Cells during Oligodendrocyte Development

open access: yesCells, 2023
Oligodendrocyte development is accompanied by defined changes in the state of chromatin that are brought about by chromatin remodeling complexes. Many such remodeling complexes exist, but only a few have been studied for their impact on oligodendrocytes ...
Vanessa Waldhauser   +3 more
doaj   +1 more source

OLIG2 regulates lncRNAs and its own expression during oligodendrocyte lineage formation

open access: yesBMC Biology, 2021
Background Oligodendrocytes, responsible for axon ensheathment, are critical for central nervous system (CNS) development, function, and diseases. OLIG2 is an important transcription factor (TF) that acts during oligodendrocyte development and performs ...
Haichao Wei   +7 more
doaj   +1 more source

Mature and Myelinating Oligodendrocytes Are Specifically Vulnerable to Mild Fluid Percussion Injury in Mice

open access: yesNeurotrauma Reports, 2023
Myelin loss and oligodendrocyte death are well documented in patients with traumatic brain injury (TBI), as well as in experimental animal models after moderate-to-severe TBI.
Alexandra A. Adams   +2 more
doaj   +1 more source

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