Results 1 to 10 of about 118,814 (348)

NF-κB RelA regulates temporal oligodendrocyte differentiation in the postnatal brains [PDF]

Frontiers in Cellular Neuroscience
The NF-κB signaling pathway responds to a diverse range of cytokines and extracellular stresses, regulating immune responses, inflammation, cell proliferation, and cell death.
Kamonrapat Sompub, Norihisa Bizen, Albert S. Baldwin, Albert S. Baldwin, Hirohide Takebayashi, Hirohide Takebayashi, Hirohide Takebayashi   +6 more
doaj   +2 more sources

Novel Animal Models for Multiple Sclerosis: R-Ras GTPases in Myelin Pathophysiology [PDF]

Biomolecules
Demyelinating diseases, such as multiple sclerosis, involve oligodendrocyte death, myelin loss, and neuronal death. These processes have been extensively studied, and a causal relationship has been demonstrated between them: destruction of ...
Gema M. Esteban-Ortega, Gonzalo Garcia-Martin, Beatriz Cubelos   +2 more
doaj   +2 more sources

Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination

eLife, 2023
In the developing central nervous system, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes, which form myelin around axons. Oligodendrocytes and myelin are essential for the function of the central nervous system, as evidenced ...
Lin Pan, Amelia Trimarco, Alice J Zhang, Ko Fujimori, Yoshihiro Urade, Lu O Sun, Carla Taveggia, Ye Zhang   +7 more
doaj   +1 more source

Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor. [PDF]

, 2014
Although astrocytes are the most abundant cell type in the central nervous system (CNS), little is known about their molecular specification and differentiation.
Chen, Yidan, Hu, Xuemei, Huang, Hao, Qiu, Mengsheng, Sander, Maike, Teng, Peng, Xie, Binghua, Zhang, Zunyi, Zhao, Xiaofeng, Zheng, Kang, Zhu, Qiang   +10 more
core   +11 more sources

Pathogenetic Mechanisms Underlying Spinocerebellar Ataxia Type 3 Are Altered in Primary Oligodendrocyte Culture

Cells, 2022
Emerging evidence has implicated non-neuronal cells, particularly oligodendrocytes, in the pathophysiology of many neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease and ...
Kristen H. Schuster, Alexandra F. Putka, Hayley S. McLoughlin   +2 more
doaj   +1 more source

Mechanosensitivity of Human Oligodendrocytes

Frontiers in Cellular Neuroscience, 2020
Oligodendrocytes produce and repair myelin, which is critical for the integrity and function of the central nervous system (CNS). Oligodendrocyte and oligodendrocyte progenitor cell (OPC) biology is modulated in vitro by mechanical cues within the ...
Daniela Espinosa-Hoyos, Suzanne R. Burstein, Jaaram Cha, Tanya Jain, Madhura Nijsure, Anna Jagielska, Anna Jagielska, Valentina Fossati, Krystyn J. Van Vliet, Krystyn J. Van Vliet, Krystyn J. Van Vliet   +10 more
doaj   +1 more source

Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. [PDF]

, 2020
One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge.
Anderson, Aileen J, Ciciriello, Andrew J, Cummings, Brian J, Dumont, Courtney M, Guo, Amina, Park, Jonghyuck, Shea, Lonnie D, Smith, Dominique R, Tatineni, Ravindra   +8 more
core   +1 more source

Oligodendrocyte precursor cell maturation: role of adenosine receptors

Neural Regeneration Research, 2021
Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and their degeneration leads to demyelinating diseases such as multiple sclerosis.
Federica Cherchi, Anna Maria Pugliese, Elisabetta Coppi   +2 more
doaj   +1 more source

High Yield of Adult Oligodendrocyte Lineage Cells Obtained from Meningeal Biopsy

Frontiers in Pharmacology, 2017
Oligodendrocyte loss can lead to cognitive and motor deficits. Current remyelinating therapeutic strategies imply either modulation of endogenous oligodendrocyte precursors or transplantation of in vitro expanded oligodendrocytes.
Sissi Dolci, Annachiara Pino, Valeria Berton, Pau Gonzalez, Alice Braga, Marta Fumagalli, Elisabetta Bonfanti, Giorgio Malpeli, Francesca Pari, Stefania Zorzin, Clelia Amoroso, Denny Moscon, Francisco J. Rodriguez, Guido Fumagalli, Francesco Bifari, Ilaria Decimo   +15 more
doaj   +1 more source

Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]

, 2016
Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai, Liu, Yan-Qun, Xie, Chong, Zhang, Guang-Xian   +3 more
core   +2 more sources