Results 1 to 10 of about 97,181 (355)

Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

Nature Neuroscience, 2020
Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a leading cause of disability for almost three decades.
Arnaud Tanti, Matthew J Suderman, Kelly Perlman   +2 more
exaly   +2 more sources

NF-κB RelA regulates temporal oligodendrocyte differentiation in the postnatal brains [PDF]

Frontiers in Cellular Neuroscience
The NF-κB signaling pathway responds to a diverse range of cytokines and extracellular stresses, regulating immune responses, inflammation, cell proliferation, and cell death.
Kamonrapat Sompub, Norihisa Bizen, Albert S. Baldwin, Albert S. Baldwin, Hirohide Takebayashi, Hirohide Takebayashi, Hirohide Takebayashi   +6 more
doaj   +2 more sources

Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders

Cellular and Molecular Life Sciences, 2021
Oligodendrocyte precursor cells (OPCs) account for 5% of the resident parenchymal central nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that occurs due to brain injury or inflammation-induced demyelination ...
Jan Spaas, Lieve van Veggel, Melissa Schepers   +2 more
exaly   +2 more sources

Altered human oligodendrocyte heterogeneity in multiple sclerosis

Nature, 2019
Oligodendrocyte pathology is increasingly implicated in neurodegenerative diseases as oligodendrocytes both myelinate and provide metabolic support to axons.
Sarah Jäkel, Eneritz Agirre, David van Bruggen   +2 more
exaly   +2 more sources

Oligodendrocyte precursor cell transplantation attenuates inflammation after ischemic stroke in mice [PDF]

Frontiers in Neurology
BackgroundDisruption of blood–brain barrier and neuroinflammation are critical pathological features in the acute phase of ischemic stroke. This study investigates whether oligodendrocyte precursor cell transplantation can downregulate inflammation to ...
Li-Ping Wang, Li-Ping Wang, Chang Liu, Yuanyuan Ma, Aijuan Yan, Guo-Yuan Yang, Xinkai Qu, Wenshi Wei   +7 more
doaj   +2 more sources

Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair

Frontiers in Cell and Developmental Biology, 2016
Oligodendrocytes are the myelinating glia of the central nervous system. Myelination of axons allows rapid saltatory conduction of nerve impulses and contributes to axonal integrity.
Renato Socodato
exaly   +2 more sources

A shared disease-associated oligodendrocyte signature among multiple CNS pathologies

Nature Neuroscience, 2022
, Benno Schwikowski, Hongjun Fu
exaly   +2 more sources

Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors

Nature Communications, 2015
Myelin regeneration can occur spontaneously in demyelinating diseases such as multiple sclerosis (MS). However, the underlying mechanisms and causes of its frequent failure remain incompletely understood.
Richard Reynolds, Robin J M Franklin
exaly   +2 more sources

Locomotor recovery following contusive spinal cord injury does not require oligodendrocyte remyelination

Nature Communications, 2018
Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor (Myrf) in remyelination after contusive SCI by deleting the gene from platelet-derived growth factor ...
Greg J Duncan, Brett J Hilton, Peggy Assinck   +2 more
exaly   +2 more sources

G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination

Nature Communications, 2016
While the formation of myelin by oligodendrocytes is critical for the function of the central nervous system, the molecular mechanism controlling oligodendrocyte differentiation remains largely unknown.
Hyun-Jeong Yang, Elior Peles
exaly   +2 more sources