Results 1 to 10 of about 64,709 (261)

Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival [PDF]

Nature Communications
The leukodystrophy Pelizaeus-Merzbacher disease (PMD) is caused by myelin protein proteolipid protein gene (PLP1) mutations. PMD is characterized by oligodendrocyte death and CNS hypomyelination; thus, increasing oligodendrocyte survival and enhancing ...
Yanan Chen, Rejani B. Kunjamma, Karin Lin, Li Kai, Maria Dima, Kody Bruce, Ian Steckler, Young Hyun Che, Jason Chan-Zervas, Jaime Eugenin von Bernhardi, Caitlin Connelly, Sude Ece, Grace Newell, Dwight E. Bergles, Carmela Sidrauski, Brian Popko   +15 more
doaj   +2 more sources

Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination

eLife, 2023
In the developing central nervous system, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes, which form myelin around axons. Oligodendrocytes and myelin are essential for the function of the central nervous system, as evidenced ...
Lin Pan, Amelia Trimarco, Alice J Zhang, Ko Fujimori, Yoshihiro Urade, Lu O Sun, Carla Taveggia, Ye Zhang   +7 more
doaj   +1 more source

Pathogenetic Mechanisms Underlying Spinocerebellar Ataxia Type 3 Are Altered in Primary Oligodendrocyte Culture

Cells, 2022
Emerging evidence has implicated non-neuronal cells, particularly oligodendrocytes, in the pathophysiology of many neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease and ...
Kristen H. Schuster, Alexandra F. Putka, Hayley S. McLoughlin   +2 more
doaj   +1 more source

Mechanosensitivity of Human Oligodendrocytes

Frontiers in Cellular Neuroscience, 2020
Oligodendrocytes produce and repair myelin, which is critical for the integrity and function of the central nervous system (CNS). Oligodendrocyte and oligodendrocyte progenitor cell (OPC) biology is modulated in vitro by mechanical cues within the ...
Daniela Espinosa-Hoyos, Suzanne R. Burstein, Jaaram Cha, Tanya Jain, Madhura Nijsure, Anna Jagielska, Anna Jagielska, Valentina Fossati, Krystyn J. Van Vliet, Krystyn J. Van Vliet, Krystyn J. Van Vliet   +10 more
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Oligodendrocyte precursor cell maturation: role of adenosine receptors

Neural Regeneration Research, 2021
Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and their degeneration leads to demyelinating diseases such as multiple sclerosis.
Federica Cherchi, Anna Maria Pugliese, Elisabetta Coppi   +2 more
doaj   +1 more source

High Yield of Adult Oligodendrocyte Lineage Cells Obtained from Meningeal Biopsy

Frontiers in Pharmacology, 2017
Oligodendrocyte loss can lead to cognitive and motor deficits. Current remyelinating therapeutic strategies imply either modulation of endogenous oligodendrocyte precursors or transplantation of in vitro expanded oligodendrocytes.
Sissi Dolci, Annachiara Pino, Valeria Berton, Pau Gonzalez, Alice Braga, Marta Fumagalli, Elisabetta Bonfanti, Giorgio Malpeli, Francesca Pari, Stefania Zorzin, Clelia Amoroso, Denny Moscon, Francisco J. Rodriguez, Guido Fumagalli, Francesco Bifari, Ilaria Decimo   +15 more
doaj   +1 more source

Serum Anti-oligodendrocyte Autoantibodies in Patients With Multiple Sclerosis Detected by a Tissue-Based Immunofluorescence Assay

Frontiers in Neurology, 2021
Multiple sclerosis (MS), the most prevalent inflammatory disease of the central nervous system (CNS), is characterized by damaged to myelin sheaths and oligodendrocytes.
Yukino Miyachi, Takayuki Fujii, Ryo Yamasaki, Daisuke Tsuchimoto, Kyoko Iinuma, Ayako Sakoda, Ayako Sakoda, Ayako Sakoda, Shoko Fukumoto, Takuya Matsushita, Katsuhisa Masaki, Noriko Isobe, Yusaku Nakabeppu, Jun-ichi Kira, Jun-ichi Kira, Jun-ichi Kira   +15 more
doaj   +1 more source

H3K9ac and HDAC2 Activity Are Involved in the Expression of Monocarboxylate Transporter 1 in Oligodendrocyte

Frontiers in Molecular Neuroscience, 2017
Recently, it is reported that monocarboxylate transporter 1 (MCT1) plays crucial role in oligodendrocyte differentiation and myelination. We found that MCT1 is strongly expressed in oligodendrocyte but weakly expressed in oligodendrocyte precursors (OPCs)
Qingwei Lai, Qingwei Lai, Wantong Du, Jian Wu, Xiao Wang, Xiao Wang, Xinyu Li, Xuebin Qu, Xiuxiang Wu, Fuxing Dong, Ruiqin Yao, Hongbin Fan, Hongbin Fan   +12 more
doaj   +1 more source

GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation

Cell Reports, 2020
Summary: Neurons and oligodendrocytes communicate to regulate oligodendrocyte development and ensure appropriate axonal myelination. Here, we show that Glycerophosphodiester phosphodiesterase 2 (GDE2) signaling underlies a neuronal pathway that promotes ...
Bo-Ran Choi, Clinton Cave, Chan Hyun Na, Shanthini Sockanathan   +3 more
doaj   +1 more source

Autophagy collaborates with apoptosis pathways to control oligodendrocyte number

Cell Reports, 2023
Summary: Oligodendrocytes are the sole myelin-producing cells in the central nervous system. Oligodendrocyte number is tightly controlled across diverse brain regions to match local axon type and number, yet the underlying mechanisms remain unclear. Here,
Tingxin Zhang, Aksheev Bhambri, Yihe Zhang, Daniela Barbosa, Han-Gyu Bae, Jumin Xue, Sabeen Wazir, Sara B. Mulinyawe, Jun Hee Kim, Lu O. Sun   +9 more
doaj   +1 more source