Results 91 to 100 of about 92,957 (356)
Advanced Science, EarlyView.Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformations, leading to seizures and stroke. Analysis of 119 446 brain cells from SWS patients uncovered distinct cell heterogeneity and identified an EDN3⁺ meningeal fibroblast cluster, with WNT5A emerging as a potential key driver of SWS progression and a promising therapeutic ...
Daosheng Ai +14 more
wiley +1 more source
eLife, 2017 Myelin, made by oligodendrocytes, is essential for rapid information transfer in the central nervous system. Oligodendrocyte precursors (OPs) receive glutamatergic synaptic input from axons but how this affects their development is unclear. Murine OPs in
E. Kougioumtzidou +7 more
semanticscholar +1 more source
Isolation and Culture of Oligodendrocytes
, 2019 Primary cultures of brain-derived rodent cells are widely used to study molecular and cellular mechanisms in neurobiology. In this chapter, we describe methods of purifying and culturing oligodendroglial cells from mouse perinatal brains. In addition, we describe methods of coculturing the purified oligodendrocytes with neurons.
Weil, Marie-Theres +8 more
openaire +3 more sources
Network-Based Genomic Analysis of Human Oligodendrocyte Progenitor Differentiation
Stem Cell Reports, 2017 Summary: Impaired human oligodendrocyte progenitor cell (hOPC) differentiation likely contributes to failed remyelination in multiple sclerosis. The characterization of molecular pathways that regulate hOPC differentiation will provide means to induce ...
Suyog U. Pol +6 more
doaj
Metabolic aspects of Neuronal – Oligodendrocytic - Astrocytic (NOA) interactions
Frontiers in Endocrinology, 2013 Whereas astrocytes have been in the limelight on the metabolic glucose interaction scene for a while, oligodendrocytes are still waiting for a place.
Ana I Amaral +5 more
doaj +1 more source
Current Insights Into Oligodendrocyte Metabolism and Its Power to Sculpt the Myelin Landscape
Frontiers in Cellular Neuroscience, 2022 Once believed to be part of the nervenkitt or “nerve glue” network in the central nervous system (CNS), oligodendroglial cells now have established roles in key neurological functions such as myelination, neuroprotection, and motor learning.
Mohanlall Narine +2 more
doaj +1 more source
α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
Advanced Science, EarlyView.A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro +14 more
wiley +1 more source
Myelin and saltatory conduction [PDF]
arXiv, 2017 Essential tutorial on myelin, oligodendrocytes and their functional relevance in the pathophysiology of the brain.
arxiv
Frontiers in Cellular Neuroscience, 2018 Oligodendrocyte progenitor cells (OPCs) are immature cells in the central nervous system (CNS) that can rapidly respond to changes within their environment by modulating their proliferation, motility and differentiation.
Renee E. Pepper +3 more
semanticscholar +1 more source
Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination
eLife, 2020 Oligodendrocytes (OLs) myelinate axons and provide electrical insulation and trophic support for neurons in the central nervous system (CNS). Platelet-derived growth factor (PDGF) is critical for steady-state number and differentiation of oligodendrocyte
Liang Zhou +9 more
doaj +1 more source