Results 41 to 50 of about 118,814 (348)

Three-dimensional co-culture platform of human induced pluripotent stem cell-derived oligodendrocyte lineage cells and neurons for studying myelination

STAR Protocols, 2023
Summary: Developing an in vitro platform to study neuron-oligodendrocyte interaction, particularly myelination, is essential to understand aberrant myelination in neuropsychiatric and neurodegenerative diseases.
Martina von der Bey, Silvia De Cicco, Susanne Zach, Bastian Hengerer, Ebru Ercan-Herbst   +4 more
doaj   +1 more source

Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease

Stem Cell Reports, 2018
Summary: Pelizaeus-Merzbacher disease (PMD) is a fatal X-linked disorder caused by loss of myelinating oligodendrocytes and consequent hypomyelination. The underlying cellular and molecular dysfunctions are not fully defined, but therapeutic enhancement ...
Matthew S. Elitt, H. Elizabeth Shick, Mayur Madhavan, Kevin C. Allan, Benjamin L.L. Clayton, Chen Weng, Tyler E. Miller, Daniel C. Factor, Lilianne Barbar, Baraa S. Nawash, Zachary S. Nevin, Angela M. Lager, Yan Li, Fulai Jin, Drew J. Adams, Paul J. Tesar   +15 more
doaj   +1 more source

Exogenous Leukemia Inhibitory Factor Stimulates Oligodendrocyte Progenitor Cell Proliferation and Enhances Hippocampal Remyelination [PDF]

, 2012
New CNS neurons and glia are generated throughout adulthood from endogenous neural stem and progenitor cells. These progenitors can respond to injury, but their ability to proliferate, migrate, differentiate, and survive is usually insufficient to ...
Deverman, Benjamin E., Patterson, Paul H.   +1 more
core   +1 more source

Embracing oligodendrocyte diversity in the context of perinatal injury

Neural Regeneration Research, 2017
Emerging evidence is fueling a new appreciation of oligodendrocyte diversity that is overturning the traditional view that oligodendrocytes are a homogenous cell population.
Jessie Newville, Lauren L Jantzie, Lee Anna Cunningham   +2 more
doaj   +1 more source

Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis and myelitis in COVID-19: a case report and a review of the literature

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2022
Background Our case explored the spectrum of autoimmune and infectious neurological complications of Coronavirus Disease 2019. In addition, we also reviewed and discussed clinical features, neuroimaging, CSF findings, and outcomes in patients with COVID ...
Mark A. Colantonio, Divine C. Nwafor, Shruti Jaiswal, Ashish K. Shrestha, Mahmoud Elkhooly, Steven Rollins, Sijin Wen, Shitiz Sriwastava   +7 more
doaj   +1 more source

Differential effects of social isolation on oligodendrocyte development in different brain regions: insights from a canine model

Frontiers in Cellular Neuroscience, 2023
Social isolation (SI) exerts diverse adverse effects on brain structure and function in humans. To gain an insight into the mechanisms underlying these effects, we conducted a systematic analysis of multiple brain regions from socially isolated and group-
Huilin Hong, Chao Guo, Chao Guo, Xueru Liu, Xueru Liu, Liguang Yang, Liguang Yang, Wei Ren, Wei Ren, Hui Zhao, Yuan Li, Zhongyin Zhou, Sin Man Lam, Jidong Mi, Zhentao Zuo, Zhentao Zuo, Cirong Liu, Cirong Liu, Guo-Dong Wang, Yan Zhuo, Yan Zhuo, Ya-Ping Zhang, Yixue Li, Guanghou Shui, Guanghou Shui, Yong Q. Zhang, Yong Q. Zhang, Ying Xiong   +27 more
doaj   +1 more source

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

Neural Regeneration Research
Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to remyelination. Failure of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve damage.
Jian Yang, Jiang Wu, Xueshun Xie, Pengfei Xia, Jinxin Lu, Jiale Liu, Lei Bai, Xiang Li, Zhengquan Yu, Haiying Li   +9 more
doaj   +1 more source

Oligodendrocyte-mediated myelin plasticity and its role in neural synchronization

eLife, 2023
Temporal synchrony of signals arriving from different neurons or brain regions is essential for proper neural processing. Nevertheless, it is not well understood how such synchrony is achieved and maintained in a complex network of time-delayed neural ...
Sinisa Pajevic, Dietmar Plenz, Peter J Basser, R Douglas Fields   +3 more
doaj   +1 more source

Evidence that an RGD-dependent receptor mediates the binding of oligodendrocytes to a novel ligand in a glial-derived matrix. [PDF]

, 1988
A simple adhesion assay was used to measure the interaction between rat oligodendrocytes and various substrata, including a matrix secreted by glial cells. Oligodendrocytes bound to surfaces coated with fibronectin, vitronectin and a protein component of
Cardwell, MC, Rome, LH
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source