Results 41 to 50 of about 92,957 (356)
eLife, 2019 Oligodendrocyte maturation is necessary for functional regeneration in the CNS; however, the mechanisms by which the systemic environment regulates oligodendrocyte maturation is unclear. We found that Transforming growth factor (TGF)-β1, which is present
Machika Hamaguchi +5 more
doaj +1 more source
ASN Neuro, 2013 Oligodendrocyte development is controlled by numerous extracellular signals that regulate a series of transcription factors that promote the differentiation of oligodendrocyte progenitor cells to myelinating cells in the central nervous system.
Teresa L. Wood +6 more
doaj +1 more source
Human induced pluripotent stem cells differentiation into oligodendrocyte progenitors and transplantation in a rat model of optic chiasm demyelination. [PDF]
PLoS ONE, 2011 BACKGROUND: This study aims to differentiate human induced pluripotent stem cells (hiPSCs) into oligodendrocyte precursors and assess their recovery potential in a demyelinated optic chiasm model in rats.
Alireza Pouya +4 more
doaj +1 more source
Neurotrauma Reports, 2023 Myelin loss and oligodendrocyte death are well documented in patients with traumatic brain injury (TBI), as well as in experimental animal models after moderate-to-severe TBI.
Alexandra A. Adams +2 more
doaj +1 more source
Exosomes and their roles in the chemoresistance of pancreatic cancer
Cancer Medicine, Volume 11, Issue 24, Page 4979-4988, December 2022., 2022 Despite the development of multiple promising chemotherapeutic agents as recommended first‐line treatment for PC, the therapeutic efficacy is largely limited by unwanted drug resistance.Exploring the relation between exosomes and chemoresistance may be conducive to understanding molecular mechanisms and taking effective measures to reduce the ...
Yubin Pan +4 more
wiley +1 more source
On a chemotaxis model with nonlinear diffusion modelling multiple sclerosis [PDF]
arXiv, 2023 We investigated existence of global weak solutions for a system of chemotaxis type with nonlinear degenerate diffusion, arising in modelling Multiple Sclerosis disease. The model consists of three equations describing the evolution of macrophages ($m$), cytokine ($c$) and apoptotic oligodendrocytes ($d$). The main novelty in our work is the presence of
arxiv
Cell morphologies in the nervous system: Glia steal the limelight
Journal of Comparative Neurology, Volume 531, Issue 3, Page 338-343, February 2023., 2023 Diversity of digitally reconstructed glia (astrocytes, oligodendrocytes, microglia, and other types) freely available for download and reuse at NeuroMorpho.Org in terms of experimental provenance, animal species, anatomical region, cell type, tracing platform, and more.
Giorgio A. Ascoli
wiley +1 more source
A physical perspective to understand myelin. I. Peters quadrant mystery [PDF]
arXiv, 2021 In the development of oligodendrocytes in the central nervous systems, the inner and outer tongue of the myelin sheath tend to be located within the same quadrant, which was named as Peters quadrant mystery. In this study, we conduct in silico investigations to explore the possible mechanisms underlying the Peters quadrant mystery.
arxiv
Projected $t$-SNE for batch correction [PDF]
Bioinformatics, 2020, 1-6, 2019 Biomedical research often produces high-dimensional data confounded by batch effects such as systematic experimental variations, different protocols and subject identifiers. Without proper correction, low-dimensional representation of high-dimensional data might encode and reproduce the same systematic variations observed in the original data, and ...
arxiv +1 more source
Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination
Nature, 2018 Regeneration of myelin is mediated by oligodendrocyte progenitor cells—an abundant stem cell population in the central nervous system (CNS) and the principal source of new myelinating oligodendrocytes. Loss of myelin-producing oligodendrocytes in the CNS
Zita M L Hubler +20 more
semanticscholar +1 more source