Results 111 to 120 of about 4,671,022 (267)

Human Fibroblast–Myeloid Cell Tissue Atlas Across the Lungs, Synovium, Skin, and Heart

Arthritis &Rheumatology, EarlyView.
Objective The availability of single‐cell RNA sequencing (scRNAseq) data in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald, Katerina Apostolopoulou, Olympia Hardy, Melpomeni Toitou, Gabriela Kania, Przemyslaw Blyszczuk, Raphael Micheroli, Thomas D. Otto, Mariola Kurowska‐Stolarska, Caroline Ospelt   +9 more
wiley   +1 more source

Conditional Deletion of LRP1 Leads to Progressive Loss of Recombined NG2-Expressing Oligodendrocyte Precursor Cells in a Novel Mouse Model

, 2019
The low-density lipoprotein receptor-related protein 1 (LRP1) is a transmembrane receptor, mediating endocytosis and activating intracellular signaling cascades.
Ina Schäfer, Anja Scheller, Aiden Haghikia, Frank Kirchhoff, Andreas Faissner, Johannes Kaisler   +5 more
core   +1 more source

Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro

Stem Cell Research, 2015
Oligodendrocytes, which are the main cell type in cerebral white matter, are generated from their precursor cells (oligodendrocyte precursor cells: OPCs).
Takakuni Maki, Yoko Takahashi, Nobukazu Miyamoto, Anna C. Liang, Masafumi Ihara, Eng H. Lo, Ken Arai   +6 more
doaj   +1 more source

Integrating chemo‐mechanical cues in nano‐microscale environments for stem cell regulation

BMEMat, EarlyView.
Nano/microscale control strategies, including nano/microscale materials, ligand spacings, and cell encapsulating gels, cell mechanics, integrin signaling, and biochemical cues to direct stem cell fate, tissue regeneration, and organoid engineering, enabling advanced biomedical applications through mechanoregulation at cell‐material interfaces ...
Rajendra K. Singh, Varsha Sagar, Amal George Kurian, Shreyas Kumar Jain, Hye Sung Kim, Hae‐Won Kim   +5 more
wiley   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

RCAS-TVA-mediated genetic targeting of oligodendrocyte lineage cells in vivo

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To develop an in vivo genetic manipulation strategy based on the replication-competent avian sarcoma/leukosis virus (RCAS)‒tumor virus receptor A (TVA) gene delivery system to specifically target oligodendrocyte lineage cells (OLCs), enabling ...
Zhang Xiaoyue, Shen Xi, Li Nannan, Hong Xiaoqi, Tong Xiaoping   +4 more
doaj   +1 more source

Transcriptomic analysis reveals distinct expression patterns in focal cortical dysplasia

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a common cause of drug‐resistant epilepsy in children and adults and exhibits substantial clinical and histopathological heterogeneity. However, morphological classification alone does not fully explain variability in epileptogenicity, disease severity, or treatment response.
Shivani Sonawane, Michal Hendrych, Michaela Ručková, Robin Jugas, Jan Vrbský, Martin Pail, Barbora Straka, Martina Strnadová, Lenka Krsková, Adam Vácha, Miroslav Koblížek, Barbora Splítková, Kateřina Koželková, Eliška Hloušková, Tereza Vaňková, Josef Zámečník, Štefánia Aulická, Markéta Hermanová, Pavel Kršek, Ondřej Slabý, Milan Brázdil   +20 more
wiley   +1 more source

In vitro characterization of the differentiation of meningeal stem/precursor cells into the oligodendrocyte lineage

, 2012
In most diseases of the spinal cord, demyelination plays an important role in the generation and progression of the neurodegenerative lesion. Despite the fact that the spinal cord shows potential for regeneration of Schwann cells, this is limited and ...
Berton, Valeria, BIFARI, Francesco, FUMAGALLI, Guido Francesco, DECIMO, Ilaria, KRAMPERA, Mauro   +4 more
core   +3 more sources

Human iPSC-Derived Neuron and Oligodendrocyte Co-culture as a Small-Molecule Screening Assay for Myelination

Bio-Protocol
Neurons and oligodendrocytes are the building blocks of the brain. Neurons form synaptic connections and transmit signals, while oligodendrocytes, including oligodendrocyte precursor cells (OPCs) and their derivatives, are vital for central nervous ...
Stefanie Chie, Zsofia Szentpetery, Melanie Generali, Tanja Kuhlmann, Giancarlo Natalucci, Maria Miletta   +5 more
doaj   +1 more source

SpaceNet: Pathology‐guided analysis of lesion‐associated spatial molecular programs

iMetaOmics, EarlyView.
Disease‐associated molecular alterations are often confined to localized pathological regions, yet current spatial transcriptomic analyses do not always use pathology or imaging information as the primary reference for defining disease‐relevant spatial contexts.
Menglei Wang, Qikun Zhao, Hudong Bao, Kaiyu Jin, Xiaohui Fan, Jie Liao   +5 more
wiley   +1 more source