Results 101 to 110 of about 4,671,022 (267)

Density-Dependent Feedback Inhibition of Oligodendrocyte Precursor Expansion

, 1996
The myelin sheath in the vertebrate CNS is formed by oligodendrocytes. The number of oligodendrocytes in a mature axon tract must be sufficient to myelinate all appropriate axons.
Hong Zhang, Robert H. Miller
core   +1 more source

Genetic Changes during Differentiation of Spermatogonial Stem Cells into Oligoprogenitor Cells

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2017
BACKGROUND AND OBJECTIVE: The culture of spermatogonial cells and the production of embryonic stem cells (ES-like cells), suggest these cells as a sufficient new source for cell therapy and for the treatment of diseases, including neurodegenerative ...
M Nazm Bojnordi, M Movahedin, T Tiraihi
doaj  

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Oligodendrocytes in central nervous system diseases: the effect of cytokine regulation

Neural Regeneration Research
Cytokines including tumor necrosis factor, interleukins, interferons, and chemokines are abundantly produced in various diseases. As pleiotropic factors, cytokines are involved in nearly every aspect of cellular functions such as migration, survival ...
Chengfu Zhang, Mengsheng Qiu, Hui Fu
doaj   +1 more source

PH20 is not expressed in murine CNS and oligodendrocyte precursor cells

Annals of Clinical and Translational Neurology, 2017
AbstractObjectiveExpression of Spam1/PH20 and its modulation of high/low molecular weight hyaluronan substrate have been proposed to play an important role in murine oligodendrocyte precursor cell (OPC) maturation in vitro and in normal and demyelinated central nervous system (CNS).
Marella, Mathieu, Ouyang, Joe, Zombeck, Jonathan, Zhao, Chunmei, Huang, Lei, Connor, Robert J., Phan, Kim B., Jorge, Michael C., Printz, Marie A., Paladini, Rudolph D., Gelb, Arnold B., Huang, Zhongdong, Frost, Gregory I., Sugarman, Barry J., Steinman, Lawrence, Wei, Ge, Shepard, H. Michael, Maneval, Daniel C., Lapinskas, Paula J.   +18 more
openaire   +2 more sources

Animal models for investigating post‐stroke cognitive impairment: A neurovascular trafficking perspective

Animal Models and Experimental Medicine, EarlyView.
Animal models enable mechanistic testing of how ischemic injury disrupts neurovascular trafficking and drives cognitive vulnerability after stroke. Complementary models capture distinct vascular, cellular, white matter, and cognitive features of PSCI.
Pratchaya Kaewkaen
wiley   +1 more source

Focal necrosis and disturbed myelination in the white matter of newborn infants: A tale of too much or too little oxygen

Frontiers in Pediatrics, 2015
White matter disease in preterm infants comes along with focal destructions or with diffuse myelination disturbance. Recent experimental work with transgenic mice paves the way for a unifying molecular model for both types of brain injury, placing oxygen
Sven eWellmann, Christoph eBührer, Thomas eSchmitz   +2 more
doaj   +1 more source

Diazoxide Promotes Oligodendrocyte Precursor Cell Proliferation and Myelination

PLoS ONE, 2010
Several clinical conditions are associated with white matter injury, including periventricular white matter injury (PWMI), which is a form of brain injury sustained by preterm infants. It has been suggested that white matter injury in this condition is due to altered oligodendrocyte (OL) development or death, resulting in OL loss and hypomyelination ...
Birgit Fogal, Carolyn McClaskey, Sha Yan, Henglin Yan, Scott A Rivkees   +4 more
openaire   +4 more sources