Results 81 to 90 of about 4,671,022 (267)

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Ramifications of microglial activation on oligodendrocytes in in vitro models of multiple sclerosis [PDF]

, 2010
Oligodendrocytes are the principal target of immune attack in multiple sclerosis (MS), where the immune system attacks the myelin sheath, leading to oligodendrocyte demise, compromised axonal saltatory conduction and eventually neuronal degeneration ...
Sevastou, I.
core  

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Elevated in vivo levels of a single transcription factor directly convert satellite glia into oligodendrocyte-like cells.

PLoS Genetics, 2015
Oligodendrocytes are the myelinating glia of the central nervous system and ensure rapid saltatory conduction. Shortage or loss of these cells leads to severe malfunctions as observed in human leukodystrophies and multiple sclerosis, and their ...
Matthias Weider, Amélie Wegener, Christian Schmitt, Melanie Küspert, Simone Hillgärtner, Michael R Bösl, Irm Hermans-Borgmeyer, Brahim Nait-Oumesmar, Michael Wegner   +8 more
doaj   +1 more source

Doublecortin in Oligodendrocyte Precursor Cells in the Adult Mouse Brain [PDF]

Frontiers in Neuroscience, 2017
Key Points Oligodendrocyte precursor cells express doublecortin, a microtubule-associated protein.Oligodendrocyte precursor cells express doublecortin, but at a lower level of expression than in neuronal precursor.Doublecortin is not associated with a potential immature neuronal phenotype in Oligodendrocyte precursor cells.
Boulanger, Jenna J., Messier, Claude
openaire   +2 more sources

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

A Molecularly Defined Midbrain Circuit Mechanism for Sound‐Driven Defensive Behavior and Anxiety

Advanced Science, EarlyView.
Schematic diagram showing the Cbln2+ ICx–dPAG circuit for sound‐driven defensive and anxiety‐like behaviors. ABSTRACT The innate defense behaviors in response to threatening sounds play a fundamental role in survival. However, the neural circuits that detect threat‐relevant auditory cues and transform them into defensive behaviors remain poorly defined.
Jie Cao, Xingxing Lai, Lifang Huo, Zhouyuan Zheng, Qian Zhang, Zhimin Ye, Panpan Wan, Chao Ma, Congping Shang   +8 more
wiley   +1 more source

Oligodendroglial heterogeneity in health, disease, and recovery: deeper insights into myelin dynamics

Neural Regeneration Research
Decades of research asserted that the oligodendroglial lineage comprises two cell types: oligodendrocyte precursor cells and oligodendrocytes. However, recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states ...
Pieter-Jan Serneels, Julie D. De Schutter, Lies De Groef, Lieve Moons, Steven Bergmans   +4 more
doaj   +1 more source

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source