Results 61 to 70 of about 4,671,022 (267)

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

Endothelial Cells Mediated by STING Regulate Oligodendrogenesis and Myelination During Brain Development

Advanced Science
Oligodendrocyte precursor cells (OPCs) migrate extensively using blood vessels as physical scaffolds in the developing central nervous system. Although the association of OPCs with the vasculature is critical for migration, the regulatory mechanisms ...
Wenwen Wang, Yanyan Wang, Libo Su, Mengtian Zhang, Tianyu Zhang, Jinyue Zhao, Hongyan Ma, Dongming Zhang, Fen Ji, Ryan Dingli Jiao, Hong Li, Yuming Xu, Lei Chen, Jianwei Jiao   +13 more
doaj   +1 more source

The role and potential therapeutic targets of astrocytes in central nervous system demyelinating diseases

Frontiers in Cellular Neuroscience, 2023
Astrocytes play vital roles in the central nervous system, contributing significantly to both its normal functioning and pathological conditions. While their involvement in various diseases is increasingly recognized, their exact role in demyelinating ...
Rui Tan, Rui Tan, Rui Hong, Chunxiao Sui, Dianxu Yang, Hengli Tian, Tao Zhu, Yang Yang   +7 more
doaj   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

15d-PGJ2 induces apoptosis of mouse oligodendrocyte precursor cells

Journal of Neuroinflammation, 2007
Background Prostaglandin (PG) production is associated with inflammation, a major feature in multiple sclerosis (MS) that is characterized by the loss of myelinating oligodendrocytes in the CNS.
Reeves Steven A, Lin Tong, Xiang Zhongmin   +2 more
doaj   +1 more source

Differentiation of Oligodendrocyte Precursor Cells from Sox10-Venus Mice to Oligodendrocytes and Astrocytes [PDF]

Scientific Reports, 2017
AbstractOligodendrocytes are well known as myelin-forming cells in the central nervous system (CNS). However, detailed mechanisms of oligodendrocyte differentiation and myelination are poorly understood, particularly due to the difficulty of the purification of murine oligodendrocyte precursor cells (OPCs).
Nobuharu Suzuki, Kaori Sekimoto, Chikako Hayashi, Yo Mabuchi, Tetsuya Nakamura, Chihiro Akazawa   +5 more
openaire   +2 more sources

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

17β-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss

Neurobiology of Disease, 2010
In addition to regulating reproductive functions in the brain and periphery, estrogen has tropic and neuroprotective functions in the central nervous system (CNS).
Lorelei C. Taylor, Kasturi Puranam, Wendy Gilmore, Jenny P-Y. Ting, Glenn K. Matsushima   +4 more
doaj   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling [PDF]

, 2022
Oligodendrocyte precursor cells exist in abundance throughout the brain lifelong, with unclear functions. Xiao et al. show that, in zebrafish, these cells regulate the precise formation of retinal ganglion cell arbors and fine-tune visual processing ...
Xiao, Yan, Czopka, Tim, Hoodless, Laura J., Petrucco, L., Portugues, R., Petrucco, Luigi, Xiao, Y., Hoodless, L., Portugues, Ruben, Czopka, Tim; id_orcid, Czopka, T.   +10 more
core   +1 more source