Results 41 to 50 of about 4,671,022 (267)

Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination. [PDF]

PLoS ONE, 2017
Agents promoting oligodendrocyte precursor cell differentiation have the potential to restore halted and/or delayed remyelination in patients with multiple sclerosis. However, few therapeutic targets have been identified.
Yongfeng Chen, Wei Zhen, Tony Guo, Yonggang Zhao, Ailian Liu, Justin P Rubio, David Krull, Jill C Richardson, Hongtao Lu, Ryan Wang   +9 more
doaj   +1 more source

Regenerative Capacity of Macrophages for Remyelination

Frontiers in Cell and Developmental Biology, 2016
White matter injury, consisting of loss of axons, myelin and oligodendrocytes, is common in many neurological disorders and is believed to underlie several motor and sensory deficits. Remyelination is the process in which the insulative myelin sheath is
Khalil eRawji, Manoj eMishra, V Wee eYong   +2 more
doaj   +1 more source

Direct association with the vascular basement membrane is a frequent feature of myelinating oligodendrocytes in the neocortex

Fluids and Barriers of the CNS, 2023
Background Oligodendrocyte lineage cells interact with the vasculature in the gray matter. Physical and functional interactions between blood vessels and oligodendrocyte precursor cells play an essential role in both the developing and adult brain ...
Justine S. C. Palhol, Maddalena Balia, Fernando Sánchez-Román Terán, Mélody Labarchède, Etienne Gontier, Arne Battefeld   +5 more
doaj   +1 more source

Oligodendrocyte precursor cell transplantation attenuates inflammation after ischemic stroke in mice

Frontiers in Neurology
BackgroundDisruption of blood–brain barrier and neuroinflammation are critical pathological features in the acute phase of ischemic stroke. This study investigates whether oligodendrocyte precursor cell transplantation can downregulate inflammation to ...
Li-Ping Wang, Li-Ping Wang, Chang Liu, Yuanyuan Ma, Aijuan Yan, Guo-Yuan Yang, Xinkai Qu, Wenshi Wei   +7 more
doaj   +1 more source

Oligodendroglial p130Cas is a target of Fyn kinase involved in process formation, cell migration and survival.

PLoS ONE, 2014
Oligodendrocytes are the myelinating glial cells of the central nervous system. In the course of brain development, oligodendrocyte precursor cells migrate, scan the environment and differentiate into mature oligodendrocytes with multiple cellular ...
Constantin Gonsior, Fabien Binamé, Carsten Frühbeis, Nina M Bauer, Peter Hoch-Kraft, Heiko J Luhmann, Jacqueline Trotter, Robin White   +7 more
doaj   +1 more source

The Many Lives of an Oligodendrocyte Precursor Cell

Annual Review of Neuroscience
Oligodendrocyte precursor cells (OPCs) are glia that give rise to myelinating oligodendrocytes in the developing and adult brain. However, emerging data suggest that OPCs perform a wide range of functions beyond oligodendrogenesis. For example, OPCs receive direct synaptic input from neurons, and they respond to neural activity through the release of ...
Buchanan, JoAnn, Cheadle, Lucas
openaire   +2 more sources

Oligodendrocyte precursor cell maturation: role of adenosine receptors

Neural Regeneration Research, 2021
Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and their degeneration leads to demyelinating diseases such as multiple sclerosis. Remyelination requires the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes but, in chronic neurodegenerative disorders, remyelination
Cherchi F., Pugliese A. M., Coppi E.
openaire   +3 more sources

Gintonin Enhances Proliferation, Late Stage Differentiation, and Cell Survival From Endoplasmic Reticulum Stress of Oligodendrocyte Lineage Cells

Frontiers in Pharmacology, 2019
Although evidence on myelin diseases is steadily accumulating, effective preventive or therapeutic strategies against them have not been established so far.
Mohammad Al Mijan, Mohammad Al Mijan, Ji Young Kim, So-Young Moon, So-Young Moon, Sun-Hye Choi, Seung-Yeol Nah, Hyun-Jeong Yang, Hyun-Jeong Yang   +8 more
doaj   +1 more source

Decreased RNA polymerase III subunit expression leads to defects in oligodendrocyte development

Frontiers in Neuroscience, 2023
IntroductionRNA polymerase III (Pol III) is a critical enzymatic complex tasked with the transcription of ubiquitous non-coding RNAs including 5S rRNA and all tRNA genes.
Julia Macintosh, Julia Macintosh, Mackenzie Michell-Robinson, Mackenzie Michell-Robinson, Xiaoru Chen, Xiaoru Chen, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard   +10 more
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source