Results 141 to 150 of about 4,671,022 (267)

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source

A posttranslational proteomic survey of a single anatomically preserved human 20‐week postconception brain

Journal of Anatomy, EarlyView.
A well‐preserved 20 post‐conception week human brain was obtained and finely dissected into 18 anatomically distinct regions, including the pia mater. Each region underwent in‐depth proteomic analysis, encompassing both total protein content and post‐translational modifications.
S. Bandiera, H. Bogetofte, P. Jensen, R. Hussain, S. A. Nischal, L. Rihova, G. J. Clowry, M. R. Larsen, Z. Molnár, B. C. Carlyle   +9 more
wiley   +1 more source

What Are the Roles of Oligodendrocyte Precursor Cells in Normal and Pathologic Conditions? [PDF]

Neurology, 2023
Benarroch E.
europepmc   +1 more source

Transcriptomic profiling of subpopulations of mouse embryonic subplate neurons

Journal of Anatomy, EarlyView.
To study gene expression in subpopulations of cortical subplate neurons (Lpar1‐EGFP‐positive and D1B‐positive SpN clusters), we applied gene expression profiling, including bulk microarray analysis, single‐cell RNA sequencing (scRNA‐seq), and Visium spatial transcriptomics, and identified both overlapping and unique gene expression signatures ...
Hitomi Achiwa, Yuichiro Hara, Hideya Kawaji, Minori Oshima, Noe Kaneko, Ayumu Morioka, Anna Hoerder‐Suabedissen, Zoltán Molnár, Chiaki Ohtaka‐Maruyama   +8 more
wiley   +1 more source

Investigating the Link Between Objective Sleep Metrics and Cerebral Small Vessel Disease in a Population‐Based Cohort

Journal of Sleep Research, EarlyView.
ABSTRACT Cerebral small vessel disease (CSVD), a disorder that affects the cerebral microvasculature, is commonly associated with aging and may contribute to dementia and stroke. Increasing evidence suggests a link between CSVD and sleep disturbances, but the association remains poorly understood.
Mareike Ludwig, Arne Böttcher, Marvin Petersen, Felix Leonard Nägele, Maximilian Schell, Jacob Friedrich Clausen, Götz Thomalla, Ines Schäfer, Alena Haack, Christian Betz, Anna Sophie Hoffmann, Bastian Cheng   +11 more
wiley   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

From mouth to brain: Linking periodontal and peri‐implant dysbiosis to systemic inflammation and neuropathology

Periodontology 2000, EarlyView.
Abstract Background/Aim Growing evidence suggests that imbalances occurring within the human microbiota and deregulation of the host immune response may play a significant role in the development of neurodegenerative diseases. Materials and Methods A comprehensive narrative review of the latest experimental, clinical, and epidemiological insights was ...
Emilio A. Cafferata, Frank Schwarz, Jaime Díaz‐Zúñiga, Alpdogan Kantarci   +3 more
wiley   +1 more source

Mechanisms underlying spontaneous and evoked calcium responses in oligodendrocyte precursor cells: A modeling investigation. [PDF]

PLoS Comput Biol
Lardy M, Wang L, Guerrier C, Cheli VT, Paez PM, Khadra A.   +5 more
europepmc   +1 more source

Characterization of postnatal brain injury and behavioural deficits in a rat model of placental insufficiency‐induced fetal growth restriction

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal growth restriction (FGR) is a common pregnancy complication associated with long‐term neurodevelopmental impairments. Using the reduced uterine perfusion pressure (RUPP) rat model of placental insufficiency‐induced FGR, this study demonstrates that FGR leads to persistent anatomical, histological and behavioural ...
Judit Alhama‐Riba, Caroline G. M. de Theije, Valentina Salvi, Dominique Viveen, Sebastiaan W. T. Corstjens, Marijke. E. J. Achterberg, Yohan van de Looij, Freek E. Hoebeek, Cora H. A. Nijboer   +8 more
wiley   +1 more source

Glucocorticoid receptors in oligodendrocyte precursor cells regulate hippocampal network plasticity and stress-induced behavior in mice. [PDF]

Proc Natl Acad Sci U S A
Mattioni L, Poggi G, Gallagher C, Becker K, Le L, Papic M, Engbers J, Koskinen MK, Abdollahzadeh A, Herzog DP, Nardi L, Conrad A, Winterberg S, Merte-Grebe C, Melo-Thomas L, Lee H, Schwarzbach H, Klüpfel J, Kinscherf R, Engelmann J, Lutz B, Waisman A, Hovatta I, Mittmann T, Schmeisser MJ, Müller MB, Treccani G.   +26 more
europepmc   +1 more source