Results 151 to 160 of about 4,671,022 (267)

Single‐Cell Integration of Mouse Models of Autism Reveals Conserved Transcriptomic Signatures of Excitatory‐Inhibitory Imbalance and Glial Dysfunction

Glia, Volume 74, Issue 12, December 2026.
Integrated scRNA‐seq from 11 ASD models reveals convergent E/I imbalance and glial dysfunction. Conserved astrocyte and oligodendrocyte dysregulation transcend model‐specific variability. Validated by human datasets. ABSTRACT The etiological heterogeneity of autism spectrum disorder (ASD) complicates identifying core molecular mechanisms.
João V. Nani, Victor J. Duque, Alysson R. Muotri, André S. Mecawi   +3 more
wiley   +1 more source

CX3CL1/CX3CR1-dependent microglial phagocytosis of oligodendrocyte precursor cells contributes to sevoflurane-induced myelination impairments in neonatal mice. [PDF]

J Neuroinflammation
Lv J, Xia Z, Wang X, Zhao P, Wu Z.
europepmc   +1 more source

An imputation method for single‐cell RNA sequencing data based on a parallel gated recurrent unit neural network

Quantitative Biology, Volume 14, Issue 4, December 2026.
Abstract Single‐cell RNA sequencing (scRNA‐seq) generates high‐dimensional transcriptomic data but is severely affected by dropout events, which obscure true gene–gene relationships. These missing values introduce bias into downstream analyses, complicate data processing, and reduce analytical efficiency.
Shuang Xu, Xiangtao Li, Jingsong Li, Yu Jiang   +3 more
wiley   +1 more source

Oligodendrocyte precursor cells in the substantia nigra: Implications for Parkinson's disease. [PDF]

Neural Regen Res
Fitzgerald JC, Pfeiffer F.
europepmc   +1 more source

MIGC: Pseudotime differentially expressed genes detection with mutual information

Quantitative Biology, Volume 14, Issue 4, December 2026.
Abstract Trajectory analysis of single‐cell RNA sequencing (scRNA‐seq) data provides insights into cell differentiation and the underlying mechanisms at the gene level. Although various pseudotime inference methods have been proposed, the detection of pseudotime differentially expressed genes (DEGs) mainly relies on generalized additive model fitting ...
Jiachen Li, Ye Yuan
wiley   +1 more source

Mechanisms of Exercise Training in Ameliorating Cognitive Function in Patients With Depression: A Narrative Review of Molecular Targets and Clinical Prescriptions

European Journal of Sport Science, Volume 26, Issue 11, November 2026.
ABSTRACT Depression is frequently accompanied by core cognitive impairments, notably in executive function and memory. Although the ameliorative effects of exercise training have been widely corroborated, the evidence regarding its underlying mechanisms remains fragmented. To provide a comprehensive and integrated view, this review proposes a testable,
Zhaohui Guo, Lingling Dong, Jessie J. X. Lin, Yanping Duan, Weizhi Liu, Wanting Jiang, Cong Liu, Shuqi Jia, Yagang Song, Feng Ding, Zhenwen Xie, Mingyue Yin, Kang Zhu, Xiaochen Ma, Peng Wang, Chen Wei, Felipe Barreto Schuch, Xing Wang   +17 more
wiley   +1 more source

Oligodendrocyte Precursor Cells Shape Retinogeniculate Refinement Via a CHD8-Dependent Phagocytic Pathway. [PDF]

Invest Ophthalmol Vis Sci
Wen S, Guo F, Li Z, Huang G, Shen M, He X.   +5 more
europepmc   +1 more source

Pathogenic Variants in HEPACAM Alter Protein Localization and Interactome in Astrocytes of the Developing Mouse Cortex

Glia, Volume 74, Issue 11, November 2026.
Pathogenic variants alter hepaCAM protein distribution. Astrocyte‐specific hepaCAM TurboID reveals KCNQ2 as a new interaction partner. Pathogenic variants alter hepaCAM association with key transmembrane proteins. ABSTRACT Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy characterized by early‐onset macrocephaly,
Robert W. Lewis, Breana C. Dogan, Amy L. Stanek, Elliot B. Evans, Madelyn G. Coble, Hayli E. Spence‐Osorio, Karen L. G. Farizatto, Angie L. Mordant, C. Allie Mills, Laura E. Herring, Katherine T. Baldwin   +10 more
wiley   +1 more source

Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer's disease. [PDF]

Signal Transduct Target Ther
Baek S, Jang J, Yeo S, Jung HJ, Choe Y.
europepmc   +1 more source

The Maintenance of Dysmyelinated Small‐Diameter Axons by 14‐3‐3s in the Central Nervous System

Glia, Volume 74, Issue 11, November 2026.
Dysmyelinated small‐diameter axons are maintained in teneurin‐4 deficient mice at the age of 1 year, while axonal damage is observed. 14‐3‐3s are highly expressed and suppress the progression of the damage in these axons. ABSTRACT In the central nervous system, myelin formed around nerve axons by oligodendrocyte enables efficient conduction of action ...
Nanako Yamada, Hinako Saito, Riko Takahashi, Mio Fujisato, Yukina Hosoda, Binri Sasaki, Momona Yamada, Sakurako Abe, Chikako Hayashi, Akira Yoshimoto, Ryunosuke Ohkawa, Tomal Julian Matt, Florence M Bareyre, Stefan Berghoff, Mikael Simons, Nobuharu Suzuki   +15 more
wiley   +1 more source