Results 171 to 180 of about 4,671,022 (267)

Canonical and non-canonical roles of oligodendrocyte precursor cells in mental disorders. [PDF]

Npj Ment Health Res
Poggi G, Treccani G, von der Bey M, Tanti A, Schmeisser MJ, Müller M.   +5 more
europepmc   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Immunoglobulin directly enhances differentiation of oligodendrocyte-precursor cells and remyelination. [PDF]

Sci Rep, 2023
Li Y, Noto D, Hoshino Y, Mizuno M, Yoshikawa S, Miyake S.   +5 more
europepmc   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, Volume 13, Issue 57, 14 October 2026.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Impaired macroautophagy in oligodendrocyte precursor cells suppresses neuronal plasticity via a senescence-associated signaling. [PDF]

Sci Adv
Chen H, Sun YY, Li QF, Du YT, Hu NN, Sui AR, Luo XQ, Huang X, Zhu C, Yang G, Yao LL, Tang Y, Hu H, Liu CF, Tao J, Feng L, Kirchhoff F, Huang W, Li S, Ma QH.   +19 more
europepmc   +1 more source

Myelination- and migration-associated genes are downregulated after phagocytosis in cultured oligodendrocyte precursor cells. [PDF]

J Neurochem, 2023
Hamanaka G, Hernández IC, Takase H, Ishikawa H, Benboujja F, Kimura S, Fukuda N, Guo S, Lok J, Lo EH, Arai K.   +10 more
europepmc   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Pen-2 regulates glial homeostasis by coordinating self-renewal and transdifferentiation programs in oligodendrocyte precursor cells. [PDF]

Stem Cell Reports
Bi H, Hou J, Shao W, Ge C, Liu Y, Wang R, Chen G, Xu Y, Wang Z.   +8 more
europepmc   +1 more source

ApoE lipidation state directs immunometabolic reprogramming of human microglia

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION ApoE ε4 is the strongest genetic risk factor for Alzheimer's disease (AD). Emerging evidence suggests that ApoE4 increases AD risk by disrupting microglial metabolism and function. However, whether ApoE lipidation state contributes to microglial dysfunction remains poorly understood. METHODS Human microglia were treated with lipid‐
Tsion G. Shiferaw, Snigdha Sarkar, Katelyn M. Baker, Rowan S. Wooldridge, Hannah M. Binfet, Victoria N. Prozapas, Chinemerem P. Ogbu, Athena A. Schepmoes, Isaac K. Attah, Christy S. Niemeyer, Kayla G. Sprenger, James E. Hassell, Robert H. Eckel, John T. Melchior, Kimberley D. Bruce   +14 more
wiley   +1 more source

Genetic association between gene expression profiles in oligodendrocyte precursor cells and psychiatric disorders. [PDF]

Front Psychiatry
Kondo R, Kimura H, Ikeda M.
europepmc   +1 more source