Results 191 to 200 of about 4,671,022 (267)

Oncolytic Virus‐Engineered Extracellular Vesicles Rewire Glioblastoma Immunity

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
ABSTRACT Immunotherapy with oncolytic Herpes simplex virus type 1 (oHSV‐1) shows promise for glioblastoma; however, clinical benefit remains uncommon due to tumour‐ and host‐mediated immunosuppression, which limits immune targeting of residual glioblastoma stem‐like cells (GSCs). To address this barrier, extracellular vesicles (EVs) harvested from oHSV‐
Klaudia Kiel, Arpita Balakrishnan, Aleksandra Cabaj, Luiza Stanaszek, Maciej Przybylski, Dawid Stępnik, Marta Małuszek, Christopher Jannotta, Chiara Zoe Linke, Joanna Suszyńska‐Zajczyk, Monika Knaur, Agnieszka Szczypiorowska, Szymon Hryhorowicz, Bianka Świderska, Katarzyna Piwocka, Alexander Lee Ling, E. Antonio Chiocca, Agnieszka Bronisz, Jakub Godlewski   +18 more
wiley   +1 more source

Protocol for sex-specific isolation of microglia, oligodendrocyte precursor cells, and astrocytes from neonatal rats using shake-off technique. [PDF]

STAR Protoc
Hamanaka G, Hoshino T, Ishikawa H, Mizutani A, Shindo A, Arai K.   +5 more
europepmc   +1 more source

Acute Neurological Manifestations in COVID‐19 Are Associated With Complement Activation and Glia‐Promoted Neuroinflammation

Journal of Medical Virology, Volume 98, Issue 10, October 2026.
ABSTRACT Pathophysiological mechanisms of neurological manifestations in COVID‐19 are not fully known yet. In this case‐control study, proteomic analysis was used to characterize cerebrospinal fluid (CSF) samples from COVID‐19 patients with acute neurological manifestations primarily categorized as: isolated refractory headache (n = 12), encephalopathy
Nicole Lardini Freitas, Yago Côrtes Pinheiro Gomes, Fábio César Sousa Nogueira, Juliana Echevarria‐Lima, João Victor Carvalho Deus, Carlos Otávio Brandão, Cristiane Nascimento Soares, Marcus Tulius Teixeira Silva, Otávio Melo Espíndola   +8 more
wiley   +1 more source

The Effect of Tumor Necrosis Factor-α and Interleu-Kin-1β on the Restorative Properties of Human Oligodendrocyte Precursor Cells In Vitro. [PDF]

Bioengineering (Basel)
Wang Z, He Y, Wang Q, Liu W, Yang Y, Zhou H, Ma X, Hu C, Luan Z, Qu S.   +9 more
europepmc   +1 more source

Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases

MedComm, Volume 7, Issue 10, October 2026.
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. We evaluate the translational potential and challenges of NK cell immunotherapies for a spectrum of neurological conditions.
Kaihang Deng, Wai Po Chong
wiley   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Bioinformatics analysis reveals key mechanisms of oligodendrocytes and oligodendrocyte precursor cells regulation in spinal cord Injury. [PDF]

Sci Rep
Yue X, Chen X, Zang Y, Wu J, Chen G, Tan H, Yang K.   +6 more
europepmc   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Identification of biomarkers in Parkinson's disease by comparative transcriptome analysis and WGCNA highlights the role of oligodendrocyte precursor cells. [PDF]

Front Aging Neurosci
Zhang FL, Li AY, Niu YL, Zhang K, Zhao MH, Huang JJ, Shen W.   +6 more
europepmc   +1 more source

Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments

MedComm, Volume 7, Issue 10, October 2026.
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma, Xiaoxuan Zhang, Pujun Zhao, Jiaxin Yang, Zhihao Li, Xiaoyang Han, Yixuan Wang, Zhenzhen Cui, Nian Liu, Min Li   +9 more
wiley   +1 more source