Results 181 to 190 of about 4,671,022 (267)

Proteomic dysregulation associated with cerebral amyloid angiopathy

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Cerebral amyloid angiopathy (CAA) is characterized by impaired vascular amyloid‐β clearance, distinct from Alzheimer's disease (AD), underscoring the need to clarify its molecular basis for predicting therapy‐related amyloid‐related imaging abnormalities. METHODS We analyzed post‐mortem brain proteomics from Religious Orders Study
Sang‐Won Han, Young Ho Park, Jung‐Min Pyun, Paula J. Bice, David A. Bennett, Shahram Oveisgharan, Andrew J. Saykin, SangYun Kim, Kwangsik Nho   +8 more
wiley   +1 more source

Interactions of Oligodendrocyte Precursor Cells and Dopaminergic Neurons in the Mouse Substantia Nigra. [PDF]

J Neurochem
Fitzgerald JC, Sun Y, Reinecke F, Bauer E, Garaschuk O, Kahle PJ, Pfeiffer F.   +6 more
europepmc   +1 more source

Context‐dependent TREM2 signalling in myeloid cells: Molecular mechanisms and immunotherapeutic divergence in neurodegeneration and cancer

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Divergent triggering receptor expressed on myeloid cells 2 (TREM2) signalling pathways instruct myeloid cell adaptation towards neuroprotective disease‐associated microglia (DAM)/lipid‐associated macrophage (LAM) or immunosuppressive tumour‐associated macrophage (TAM) phenotypes.
Yaqing Lv, Mingpeng Shi, Yongfei Zhao, Yi Yu, Jiawei Lv, Hai Zhao   +5 more
wiley   +1 more source

Aging and senescent fates of oligodendrocyte precursor cells in the mouse brain. [PDF]

NPJ Aging
Gomez PT, Carver CM, Rodriguez SL, Wang L, Zhang X, Schafer MJ.   +5 more
europepmc   +1 more source

Predicting Relevant Microglia‐Associated Cell–Cell Communication Pathways in Alzheimer's Disease: A Role for SPP1

Glia, Volume 74, Issue 10, October 2026.
We used CellChat to infer altered cell–cell communication in Alzheimer's disease Microglia signal to each other via SPP1 in Alzheimer's disease. SPP1‐expressing microglia are present around amyloid‐β plaques. ABSTRACT Microglia play a key role in the pathophysiology of Alzheimer's Disease (AD) and their increased heterogeneity likely affects disease ...
Janssen M. Kotah, Marina Trombetta Lima, Esmée C. Dragt, Asimenia Voulgaroglou, Nieske Brouwer, Inge R. Holtman, Susanne M. Kooistra, Bart J. L. Eggen   +7 more
wiley   +1 more source

Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States

Glia, Volume 74, Issue 10, October 2026.
Proximity labeling enables cell‐type‐specific and spatially resolved mapping of glial protein networks. Proximity labeling approaches provide insights into glial function under physiological and pathological conditions. ABSTRACT Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are ...
João Baltar, Rebecca Abati, Luísa Florido, Matthew G. Holt   +3 more
wiley   +1 more source

Repurposed Drugs to Enhance the Therapeutic Potential of Oligodendrocyte Precursor Cells Derived from Adult Rat Adipose Tissue. [PDF]

Cells
Pascual-Guerra J, Torres-Rico M, Marín-Rodríguez B, Arasmou-Idrovo MS, García AG, Rodríguez-Navarro JA, Paíno CL.   +6 more
europepmc   +1 more source

Astrocyte‐enriched and cilia‐related genetic signatures in dementia: A whole‐exome sequencing study

General Psychiatry, Volume 39, Issue 5, October 2026.
ABSTRACT Background Alzheimer's disease (AD), the most prevalent form of dementia, is highly heritable, yet much of its genetic basis remains unexplained. Most genetic studies have focused on European populations, with limited data from under‐represented groups.
Miaohan Deng, Yucan Chen, Lu Zhao, Weichen Song, Qi Qiu, Lin Sun, Xiang Lin, Weidi Wang, Guan Ning Lin, Xia Li   +9 more
wiley   +1 more source

Protection From Demyelination by the Novel Adenosine Dual A_2A/A_2B Receptor Antagonist P626 in EAE and Cultured Oligodendrocyte Precursor Cells. [PDF]

J Cell Mol Med
Morozzi M, Cherchi F, Sasia C, Frulloni L, Videtta G, Venturini M, Catarzi D, Varano F, Calenda S, Ceni C, Vagnoni G, Colotta V, Coppi E, Pugliese AM, Galeotti N.   +14 more
europepmc   +1 more source

Agrin‐Enriched Neonatal Spinal Cord‐Derived Extracellular Vesicles Bypass Age Barriers to Organize Spinal Cord Repair

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
ABSTRACT Spinal cord injury (SCI) poses a formidable challenge in regenerative medicine, with current therapeutic strategies proving largely unsuccessful in achieving functional repair. Notably, paediatric patients and neonatal mice exhibit spontaneous and efficient regeneration after SCI, while the mechanisms remain elusive.
Yongfeng Zhang, Qi Liu, Beibei Yu, Borui Xue, Shijie Yang, Teng Ma, Lingli Guo, Haining Wu, Xue Gao, Shengyou Li, Yujie Yang, Yiming Hao, Ziqing Zhu, Meijia Su, Hongyu Li, Shuanshuan Fan, Jiaqi Wang, Huangtao Chen, Longhui Fu, Anhui Qin, Zhenguo Wang, Shihao Nie, Mingze Qin, Xinxin Bai, Guang Kong, Rui Zhao, Dong Lei, Yue Yu, Junxiong Ma, Shouping Gong, Bing Xia, Jinghui Huang   +31 more
wiley   +1 more source