Results 51 to 60 of about 113,519 (282)

pH Microdomains in Oligodendrocytes [PDF]

Journal of Biological Chemistry, 2004
Oligodendrocytes (OLs) are cells that produce myelin in the central nervous system. Here we use ratiometric pH indicator dye to analyze intracellular pH in OLs in culture. The results reveal alkaline microdomains, which predominate in the perikaryon and proximal dendrites, and acidic microdomains, which predominate in distal dendrites.
Hyun-ah, Ro, John H, Carson
openaire   +2 more sources

MicroRNA-23a promotes myelination in the central nervous system. [PDF]

, 2013
Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment ...
Fu, Ying-Hui, Heng, Mary Y, Huang, Yong, Lin, Shu-Ting, Ptácek, Louis J, Zhang, Luoying   +5 more
core   +2 more sources

Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. [PDF]

, 2020
One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge.
Anderson, Aileen J, Ciciriello, Andrew J, Cummings, Brian J, Dumont, Courtney M, Guo, Amina, Park, Jonghyuck, Shea, Lonnie D, Smith, Dominique R, Tatineni, Ravindra   +8 more
core   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Seed-induced Aβ deposits in the corpus callosum disrupt white matter integrity in a mouse model of Alzheimer’s disease

Frontiers in Cellular Neuroscience, 2022
Neuropathologically, Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-beta peptide (Aβ) and subsequent formation of the so-called Aβ plaques.
Vanessa Aires, Vanessa Aires, Vanessa Aires, Stephanie Ziegler-Waldkirch, Stephanie Ziegler-Waldkirch, Marina Friesen, Marina Friesen, Marina Friesen, Wilfried Reichardt, Wilfried Reichardt, Wilfried Reichardt, Wilfried Reichardt, Daniel Erny, Daniel Erny, Daniel Erny, Desiree Loreth, Desiree Loreth, Desiree Loreth, Andrew Harborne, Andrew Harborne, Oliver Kretz, Dominik von Elverfeldt, Dominik von Elverfeldt, Melanie Meyer-Luehmann, Melanie Meyer-Luehmann, Melanie Meyer-Luehmann   +25 more
doaj   +1 more source

Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. [PDF]

, 2019
Mesenchymal stem/stromal cells (MSCs) display potent immunomodulatory and regenerative capabilities through the secretion of bioactive factors, such as proteins, cytokines, chemokines as well as the release of extracellular vesicles (EVs).
Barthe, Sylvain, Clark, Kaitlin, Farmer, Diana, Guo, Fuzheng, Kreutzberg, Nicole, Kumar, Priyadarsini, Paxton, Zachary, Pivetti, Christopher, Reed, Camille, Wang, Aijun, Wang, Yan, Zhang, Sheng   +11 more
core   +2 more sources

Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs [PDF]

, 2020
In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by
Chen, Xiaohong, Faller, Douglas V., Glavas, Ioannis P., Harpp, David N., Kanara, Iphigenia, Kodukula, Krishna, Mavrakis, Anastasios N., Moos, Walter H., Pernokas, Julie, Pernokas, Mark, Pinkert, Carl A., Powers, Whitney R., Sampani, Konstantina, Steliou, Kosta, Vavvas, Demetrios G., Zamboni, Robert J.   +15 more
core   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

Retrovirus-Mediated Gene Transfer and Galactocerebrosidase Uptake into Twitcher Glial Cells Results in Appropriate Localization and Phenotype Correction

Neurobiology of Disease, 2001
Galactocerebrosidase (GALC) is deficient in all tissues from human patients and animal models with globoid cell leukodystrophy (GLD) or Krabbe disease.
A. Luddi, M. Volterrani, M. Strazza, A. Smorlesi, M.A. Rafi, J. Datto, D.A. Wenger, E. Costantino-Ceccarini   +7 more
doaj   +1 more source

Oligodendrocytes: biology and pathology [PDF]

Acta Neuropathologica, 2009
Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are the end product of a cell lineage which has to undergo a complex and precisely timed program of proliferation, migration, differentiation, and myelination to finally produce the insulating sheath of axons.
Bradl, Monika, Lassmann, Hans
openaire   +2 more sources