Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis [PDF]
Epidemiological, biochemical, animal model and clinical trial data described in this overview strongly suggest that polyunsaturated fatty acids, particularly n-6 fatty acids, have a role in the pathogenesis and treatment of multiple sclerosis (MS).
Copeland +16 more
core +2 more sources
This study represents the first scRNA‐seq investigation revealing cellular heterogeneity during the hyperacute (3 h), acute (2 days), and subacute (7 days) phases of neonatal hypoxic–ischemic encephalopathy (HIE). ABSTRACT Neonatal hypoxic–ischemic encephalopathy (HIE) is a severe neurological condition associated with high rates of mortality or long ...
Xianbo Chen, Xiaohong Tao, Jingyu Wang
wiley +1 more source
Heterogeneity of mature oligodendrocytes in the central nervous system
Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.
Chao Weng +6 more
doaj +1 more source
New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond
The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, guided by gains in understanding the fundamental immunology, neurobiology, genetics, and triggers of this disease, have broadened the traditional focus on ...
Joseph J. Sabatino Jr. +2 more
wiley +1 more source
Abstract Background Dysphagia significantly impacts prognosis in individuals with multiple system atrophy (MSA). While video‐based assessments are practical, their limited availability highlights the need for a simple tool such as the Dysphagia Severity Scale (DSS) in clinical practice.
Ryunosuke Nagao +8 more
wiley +1 more source
Mosaic subventricular origins of forebrain oligodendroglia
In the perinatal as well as the adult CNS, the subventricular zone (SVZ) of the forebrain is the largest and most active source of neural stem cells (NSCs) that generates neurons and oligodendrocytes (OLs), the myelin forming cells of the CNS.
Kasum eAzim +2 more
doaj +1 more source
Induction of annexin-1 at transcriptional and posttranscriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F [PDF]
Jan Kornelis de Cock ...
Go, KG +5 more
core
Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma [PDF]
Ependymal tumors constitute a clinicopathologically heterogeneous group of brain tumors. They vary in regard to their age at first symptom, localization, morphology and prognosis. Genetic data also suggests heterogeneity.
Chapon, F +11 more
core +3 more sources
The bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability. [PDF]
It was recently discovered that vertebrate genomes contain multiple endogenised nucleotide sequences derived from the non-retroviral RNA bornavirus.
A Aswad +33 more
core +2 more sources
CNS Mitochondria‐Derived Vesicle in Blood: Potential Biomarkers for Brain Mitochondria Dysfunction
ABSTRACT Objective Mitochondrial dysfunction is a hallmark of neurodegenerative diseases like Alzheimer's (AD) and Parkinson's (PD). Our goal was to develop practical, noninvasive methods to assess mitochondrial status through the detection of mitochondria‐derived vesicles (MDVs).
Qi Liu +12 more
wiley +1 more source

