Results 91 to 100 of about 17,381 (266)
Chronic alcohol abuse is implicated in the oxidative stress and the changes in the neurotrophic factor receptor expression in the human CNS [PDF]
, 2011 Alcohol abuse and alcoholism induce brain damage, and, in some cases, neurodegeneration. The pathogenesis of the alcohol-induced injury of the CNS is a complex process in which oxidative stress plays an essential role.
Groma, V., Kleina, R., Skuja, Sandra
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Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways
PROTEOMICS, EarlyView.ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu +3 more
wiley +1 more source
The Absolute Number of Oligodendrocytes in the Adult Mouse Brain
Frontiers in Neuroanatomy, 2018 The central nervous system is a highly complex network composed of various cell types, each one with different subpopulations. Each cell type has distinct roles for the functional operation of circuits, and ultimately, for brain physiology in general ...
Bruna Valério-Gomes +4 more
doaj +1 more source
Epilepsia, EarlyView.Abstract Objective Mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) are brain lesions associated with focal epilepsy and characterized by increased oligodendroglial density, heterotopic neurons, and hypomyelination in the white matter.
Isabella C. Galvão +10 more
wiley +1 more source
eLife, 2022 The differentiation of oligodendroglia from oligodendrocyte precursor cells (OPCs) to complex and extensive myelinating oligodendrocytes (OLs) is a multistep process that involves large-scale morphological changes with significant strain on the ...
Emeric Merour +15 more
doaj +1 more source
Unprecedented Combination of Rare Degenerative Pathologies in an Octogenarian Ex‐Football Player
Neuropathology, EarlyView.ABSTRACT A 79‐year‐old former professional football player presented with language deficits and cognitive changes. A year later, he had difficulty completing sentences, and 3 years after onset, was reduced to one‐word answers. He developed severe apathy and agitation, and became more impulsive.
Shelley L. Forrest +6 more
wiley +1 more source
Borna disease virus infection perturbs energy metabolites and amino acids in cultured human oligodendroglia cells. [PDF]
PLoS ONE, 2012 BACKGROUND: Borna disease virus is a neurotropic, non-cytolytic virus that has been widely employed in neuroscientific research. Previous studies have revealed that metabolic perturbations are associated with Borna disease viral infection.
Rongzhong Huang +12 more
doaj +1 more source
Glia, Volume 73, Issue 7, Page 1383-1397, July 2025.Main Points Ablation of autophagy in oligodendrocytes reveals increased PLP expression, myelin abnormalities, axon degeneration and increased microglia activation in aged mice. The aged mice exhibit marked deficits in learning and memory tasks. ABSTRACT The aging central nervous system (CNS) is often marked by myelin degeneration, yet the underlying ...
Niki Ktena +8 more
wiley +1 more source
Differences in the soluble and insoluble proteome between primary tauopathies
Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.Abstract INTRODUCTION Primary tauopathies, including corticobasal degeneration (CBD), Pick's disease (PiD), and progressive supranuclear palsy (PSP), have aggregated tau pathology in the brain. Many other proteins are likely altered in disease; however, these have not been well characterized.
Tomas Kavanagh +7 more
wiley +1 more source
Sources of extracellular glutamate in developing white matter [PDF]
, 2011 Neurotransmitters mediate synaptic communication between neurons and are therefore fundamental to such essential human characteristics as learning, memory, cognition and persona.
Fern, Robert
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