Results 101 to 110 of about 15,473 (242)

Disruption of Oligodendroglial Autophagy Leads to Myelin Morphological Deficits, Neuronal Apoptosis, and Cognitive Decline in Aged Mice

Glia, Volume 73, Issue 7, Page 1383-1397, July 2025.
Main Points Ablation of autophagy in oligodendrocytes reveals increased PLP expression, myelin abnormalities, axon degeneration and increased microglia activation in aged mice. The aged mice exhibit marked deficits in learning and memory tasks. ABSTRACT The aging central nervous system (CNS) is often marked by myelin degeneration, yet the underlying ...
Niki Ktena, Dimitrios Spyridakos, Alexandros Georgilis, Ilias Kalafatakis, Efstathia Thomoglou, Angeliki Kolaxi, Vassiliki Nikoletopoulou, Maria Savvaki, Domna Karagogeos   +8 more
wiley   +1 more source

Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates

Acta Neuropathologica Communications, 2017
Multiple system atrophy (MSA) is a horrible and unrelenting neurodegenerative disorder with an uncertain etiology and pathophysiology. MSA is a unique proteinopathy in which alpha-synuclein (α-syn) accumulates preferentially in oligodendroglia rather ...
Ronald J. Mandel, David J. Marmion, Deniz Kirik, Yaping Chu, Clifford Heindel, Thomas McCown, Steven J. Gray, Jeffrey H. Kordower   +7 more
doaj   +1 more source

A dementia neuropathológiája Parkinson-syndromákban = Neuropathology of dementia in Parkinson's syndromes [PDF]

, 2008
Vizsgálatainkban Parkinson-syndromákban (multiszisztémás atrophia, Parkinson-kór, progresszív supranuclearis bénulás, vascularis parkinsonismus (Binswanger-betegség) a dementia neuropathológiai hátterét objektív sejtszámlálási módszerekkel vizsgáltuk, az
Csillik, Anita, Koroncai, Erzsébet, Kovács, Tibor, Papp, Mátyás, Szirmai, Imre   +4 more
core  

Herstellung und Charakterisierung von menschlichen Oligodendrozyten-Vorläuferzellinien [PDF]

, 2006
Bei der Multiplen Sklerose kommen im Verlauf der Erkrankung das Myelin und die Oligodendrozyten zu Schaden. Zu Beginn der Erkrankung kann man Remyelinisierungsvorgänge beobachten.
Onischke, Claus, Sommer, N. (Prof)
core   +1 more source

Differences in the soluble and insoluble proteome between primary tauopathies

Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.
Abstract INTRODUCTION Primary tauopathies, including corticobasal degeneration (CBD), Pick's disease (PiD), and progressive supranuclear palsy (PSP), have aggregated tau pathology in the brain. Many other proteins are likely altered in disease; however, these have not been well characterized.
Tomas Kavanagh, Kaleah Balcomb, Stephanie Trgovcevic, Laura Nementzik, Evgeny Kanshin, Glenda Halliday, Beatrix Ueberheide, Eleanor Drummond   +7 more
wiley   +1 more source

Opioid system diversity in developing neurons, astroglia, and oligodendroglia in the subventricular zone and striatum: Impact on gliogenesis in vivo [PDF]

, 2001
Anne Stiene‐Martin, Pamela E. Knapp, Kenneth Martin, Julie A. Gurwell, Shawn Ryan, Suzanne R. Thornton, Forrest L. Smith, Kurt F. Hauser   +7 more
openalex   +2 more sources

Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility [PDF]

, 2022
Mandy Meijer, Eneritz Agirre, Mukund Kabbe, Cassandra A. van Tuijn, Abeer Heskol, Chao Zheng, Ana Mendanha Falcão, Marek Bartošovič, Leslie A. Kirby, Daniela Calini, Michael R. Johnson, M. Ryan Corces, Thomas J. Montine, Xingqi Chen, Howard Y. Chang, Dheeraj Malhotra, Gonçalo Castelo‐Branco   +16 more
openalex   +1 more source

Injuring neurons induces neuronal differentiation in a population of hippocampal precursor cells in culture

Neurobiology of Disease, 2006
A novel population of hippocampal precursor cells (HPCs) that can be induced to differentiate into astrocytes and oligodendrocytes can be derived from hippocampal cultures grown in serum-free media.
Henry C. Tseng, Stephan J. Ruegg, Margaret Maronski, Conrad A. Messam, Judith B. Grinspan, Marc A. Dichter   +5 more
doaj   +1 more source

DYRK1A haploinsufficiency affects the development of astroglia and oligodendroglia, and axonal conductivity in the brain [PDF]

, 2022
Isabel Pijuan, Elisa Balducci, Cristina Soto‐Sánchez, Eduardo Fernández, Marı́a José Barallobre, María L. Arbonés   +5 more
openalex   +1 more source

Editorial: Non-neuronal cell heterogeneity in the nervous system during health and disease

Frontiers in Cellular Neuroscience, 2022
Greg J. Duncan, Peggy Assinck, Jo Anne Stratton, Bahareh Ajami, Jason R. Plemel, Jason R. Plemel, Jason R. Plemel   +6 more
doaj   +1 more source