Results 1 to 10 of about 125,755 (100)
Amyloid oligomers as on-pathway precursors or off-pathway competitors of fibrils
Frontiers in Molecular Biosciences, 2023 Amyloid Diseases involve the growth of disease specific proteins into amyloid fibrils and their deposition in protein plaques. Amyloid fibril formation is typically preceded by oligomeric intermediates.
Martin Muschol +2 more
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Reactions of a trans-diamminediaquaplatinum(II) complex with L-cysteine
Macedonian Journal of Chemistry and Chemical Engineering, 2021 The reaction of a trans-diamminediaquaplatinum(II) complex, trans-[Pt(15NH3)2(H2O)2]2+ (1), and L-cysteine (R–SH) has been performed to confirm the formation of the products in the solution.
Sutopo Hadi +4 more
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Frontiers in Allergy, 2023 Protein modifications such as oligomerization and tyrosine nitration alter the immune response to allergens and may contribute to the increasing prevalence of allergic diseases.
Janine Fröhlich-Nowoisky +4 more
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Synaptic Disruption by Soluble Oligomers in Patients with Alzheimer’s and Parkinson’s Disease
Biomedicines, 2022 Neurodegenerative diseases are the result of progressive dysfunction of the neuronal activity and subsequent neuronal death. Currently, the most prevalent neurodegenerative diseases are by far Alzheimer’s (AD) and Parkinson’s (PD) disease, affecting ...
Berenice A. Gutierrez, Agenor Limon
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Frontiers in Pharmacology, 2020 Oligomeric assembly of Amyloid-β (Aβ) is the main toxic species that contribute to early cognitive impairment in Alzheimer’s patients. Therefore, drugs that reduce the formation of Aβ oligomers could halt the disease progression.
Taweesak Tangrodchanapong +2 more
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Extracellular Alpha-Synuclein: Mechanisms for Glial Cell Internalization and Activation
Biomolecules, 2022 Alpha-synuclein (α-syn) is a small protein composed of 140 amino acids and belongs to the group of intrinsically disordered proteins. It is a soluble protein that is highly expressed in neurons and expressed at low levels in glial cells.
Cecilia Chavarría +2 more
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Proteostasis Response to Protein Misfolding in Controlled Hypertension
Cells, 2022 Hypertension is the most determinant risk factor for cardiovascular diseases. Early intervention and future therapies targeting hypertension mechanisms may improve the quality of life and clinical outcomes.
Manuel Teixeira +12 more
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Neuropathology of the Alzheimer's continuum: an update
Free Neuropathology, 2020 Alzheimer’s disease (AD), the most common form of dementia worldwide, is a mixed proteinopathy (amyloid and tau). Originally defined as a clinicopathological entity, it is a heterogenous, multifactorial disorder, currently referred to as the Alzheimer’s ...
Kurt A. Jellinger
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The elusive nature and diagnostics of misfolded Aβ oligomers.
Frontiers in Chemistry, 2015 Amyloid-beta (Aβ) peptide oligomers are believed to be the causative agents of Alzheimer’s disease (AD). Though post-mortem examination shows that insoluble fibrils are deposited in the brains of AD patients in the form of intracellular (tangles) and ...
Eleonora eCerasoli +2 more
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The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity
EMBO Molecular Medicine, 2022 Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD). However, the etiology of its noxious cellular effects remains elusive.
Julia Ring +39 more
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