Results 11 to 20 of about 125,904 (241)
Characteristics of tau oligomers [PDF]
Frontiers in Neurology, 2013 In Alzheimer disease (AD) and other tauopathies, microtubule-associated protein tau becomes hyperphosphorylated, undergoes conformational changes, aggregates, eventually becoming neurofibrillary tangles (NFTs). As accumulating evidence suggests that NFTs
Yan eRen, Naruhiko eSahara
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Tau Oligomers Neurotoxicity [PDF]
Life, 2021 Although the mechanisms of toxic activity of tau are not fully recognized, it is supposed that the tau toxicity is related rather not to insoluble tau aggregates but to its intermediate forms. It seems that neurofibrillar tangles (NFTs) themselves, despite being composed of toxic tau, are probably neither necessary nor sufficient for tau-induced ...
Grazyna Niewiadomska +3 more
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Nitrogen Backbone Oligomers [PDF]
Scientific Reports, 2015 AbstractWe found that nitrogen and hydrogen directly react at room temperature and pressures of ~35 GPa forming chains of single-bonded nitrogen atom with the rest of the bonds terminated with hydrogen atoms - as identified by IR absorption, Raman, X-ray diffraction experiments and theoretical calculations.
Hongbo Wang +5 more
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Stabilization of a Membrane-Associated Amyloid-β Oligomer for Its Validation in Alzheimer's Disease
Frontiers in Molecular Biosciences, 2018 We have recently reported on the preparation of a membrane-associated β-barrel Pore-Forming Aβ42 Oligomer (βPFOAβ42). It corresponds to a stable and homogeneous Aβ42 oligomer that inserts into lipid bilayers as a well-defined pore and adopts a specific ...
Montserrat Serra-Batiste +6 more
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Paradigm study on risk assessment methodology of oligomers in food contact materials
Zhongguo shipin weisheng zazhi, 2023 Risk assessment of non-intentionally added substances， including oligomers， in food contact materials is of great importance for ensuring food safety. Research articles and risk assessment reports at home and abroad were collected to analyze the sources ...
ZHOU Shiqi +4 more
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Anticancer and Anti-Inflammatory Properties of Chitin and Chitosan Oligosaccharides
Journal of Functional Biomaterials, 2015 Previous reports indicate that N-acetyl-d-glucosamine oligomers (chitin oligosaccharide; NACOS) and d-glucosamine oligomers (chitosan oligosaccharide; COS) have various biological activities, especially against cancer and inflammation. In this review, we
Kazuo Azuma +3 more
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Hyperphosphorylation-Induced Tau Oligomers [PDF]
Frontiers in Neurology, 2013 In normal adult brain the microtubule associated protein (MAP) tau contains 2-3 phosphates per mol of the protein and at this level of phosphorylation it is a soluble cytosolic protein. The normal brain tau interacts with tubulin and promotes its assembly into microtubules and stabilizes these fibrils.
Iqbal, Khalid, Gong, Cheng-Xin, Liu, Fei
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Study on graphene oxide modified by oligomers of p-phenylenediamine for supercapacitors
矿业科学学报, 2019 In order to obtain high specific capacitance of the electrode used for supercapacitors based on new carbon materials,graphene oxide(GO),from graphite oxidized by chemicals,was modified by oligomers of p-phenylenediamine in an autoclave.The changes of ...
Zhang Qingqing +5 more
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Drug‐resistant epilepsy: Drug target hypothesis and beyond the receptors
Epilepsia Open, 2022 Epilepsy is a chronic neurological disorder that affects more than 50 million people worldwide. Despite a recent introduction of antiseizure drugs for the treatment of epileptic seizures, one‐third of these patients suffer from drug‐resistant epilepsy ...
Daniel Fonseca‐Barriendos +5 more
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The Influence of Alkali Metals on the Doping of Poly(p-phenylene) Oligomers
Molecules, 2022 In this study, we report on crystallographic studies that were performed on Na- and K-doped terphenyl and quaterphenyl. The data obtained via X-ray scattering and transmission electron diffraction show that, for both K-doped terphenyl and quaterphenyl ...
Laura Oliveira Péres +2 more
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