Results 121 to 130 of about 15,131 (222)

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy. [PDF]

Adv Sci (Weinh)
Zhao X, Zhou Q, Li M, Zou W, Zhang Z, Shi J, Liu J.   +6 more
europepmc   +1 more source

Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders

The FEBS Journal, EarlyView.
Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo, Bastien Morlet, Luc Negroni, Orsolya Mózner, Balázs Sarkadi, Gilles Travé, Gergo Gogl   +6 more
wiley   +1 more source

Recent developments in the delivery of peptide nucleic acids (PNAs). [PDF]

RSC Chem Biol
Sarkar S, Murthy N.
europepmc   +1 more source

Functional Characterization of the Cat and Dog Wild‐Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Lisa Siegl, Mies Bethäuser, Daniela Nürnberger, Stefan Oswald, Andreas Moritz, Melanie Hamann, Joachim Geyer   +6 more
wiley   +1 more source

Peptide-Oligonucleotide Conjugates: Catalytic Preparation in Aqueous Solution or On-Column. [PDF]

Curr Protoc
Gras M, Smietana M, Adler P.
europepmc   +1 more source

The Ti Plasmid‐Encoded VirJ Functions as a Lysyl‐Phosphatidylglycerol Hydrolase in Agrobacterium tumefaciens

Molecular Microbiology, EarlyView.
We identify the long‐known virulence factor VirJ as a lysyl‐phosphatidylglycerol (L‐PG) hydrolase. Like the chromosomally encoded virulence factor AcvB, it prevents excessive accumulation of L‐PG in the membrane, thereby maintaining efficient T‐DNA transfer via the Type IV secretion system (T4SS) in Agrobacterium tumefaciens.
Britta Lotz, Lina Brodskaia, Christiane Fritz, Stefanie Hebecker, Maike K. Tauchert, Jennifer Breisch, Dieter Jahn, Franz Narberhaus, Jürgen Moser, Meriyem Aktas   +9 more
wiley   +1 more source

Peptide Nucleic Acids (PNAs) in Antimicrobial Therapy: A Next Generation Strategy. [PDF]

Int J Mol Sci
D'Aniello A, Masi A, Avitabile C, Del Monaco G, Saviano M, Moccia M.   +5 more
europepmc   +1 more source

The Arabidopsis NPF7.2 mediates coumarin uptake for root iron acquisition

New Phytologist, EarlyView.
Summary Iron (Fe) is a transition metal necessary for achieving essential physiological processes throughout the plant lifecycle. In Arabidopsis thaliana, secreting Fe‐mobilizing coumarins (FMC) is a key mechanism enabling roots to acquire nonbioavailable Fe present in soils.
Shunsuke Watanabe, Meijie Li, Alice Rossille, Chérhazad Boustani, Kevin Robe, Yuri Kanno, Mitsunori Seo, Christian Dubos   +7 more
wiley   +1 more source

A Novel Hybrid LC-MS/MS Methodology for the Quantitative Bioanalysis of Antibody-siRNA Conjugates. [PDF]

Anal Chem
Song Z, Yuan L.
europepmc   +1 more source

GmSNAP14: a key contributor to soybean cyst nematode resistance in soybean

New Phytologist, EarlyView.
Summary Soybean (Glycine max) plants counteract soybean cyst nematode (SCN, Heterodera glycines Ichinohe) infection through an impairment of soluble N‐ethylmaleimide‐sensitive factor (NSF) attachment protein (α‐SNAP) – NSF interactions and vesicular trafficking leading to cellular toxicity in response to nematode feeding.
Vinavi A. Gamage, Mariola Usovsky, Anser Mahmood, Elizabeth De Meyer, Bishnu Dhital, Clinton G. Meinhardt, Qijian Song, Lesa J. Beamer, Andrew M. Scaboo, Melissa G. Mitchum   +9 more
wiley   +1 more source