Results 191 to 200 of about 81,829 (260)

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Relationship Between Omega-3 Fatty Acids and Glaucoma Risk in Patients With Dry Eye Disease: A Multinational Retrospective Cohort Study. [PDF]

Transl Vis Sci Technol
Pan SY, Sheen YJ, Weng CH, Chen JP, Lin HJ, Wang IJ, Chou CC.   +6 more
europepmc   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Associations Between Circulating Polyunsaturated Fatty Acids and Photoreceptor Measurement. [PDF]

Transl Vis Sci Technol
Chen J, Liu H, Li Y, Zhuo Y, Li Z, Zhuo Y, Zhu Y, Tu S.   +7 more
europepmc   +1 more source

Dual Glucagon and GLP‐1 Receptor Agonist Survodutide Improves Biomarkers of Beta‐Cell Function and Insulin Sensitivity in People With Type 2 Diabetes or Living With Overweight/Obesity

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims This post hoc analysis evaluated the effect of survodutide on beta‐cell function, insulin sensitivity, and glucose biomarkers in two phase 2 trial populations. Materials and Methods Trial 1404‐0002 randomised 413 participants with type 2 diabetes on metformin to receive survodutide, placebo, or semaglutide over 16 weeks.
Elif I. Ekinci, Sandra González Maldonado, Anna Unseld, Jorge Arrubla Martinez, Anita M. Hennige, Corinna Schoelch   +5 more
wiley   +1 more source

Association Between SGLT2 Inhibitors and DPP‐4 Inhibitors Use and Risk of Acute Pancreatitis: Findings From Nationwide Case‐Based Analyses

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims The Korean national health insurance claims database was utilised to investigate the association between sodium–glucose cotransporter 2 inhibitors (SGLT2i) or dipeptidyl peptidase‐4 inhibitors (DPP‐4i) and the risk of acute pancreatitis (AP). Materials and Methods Patients with type 2 diabetes mellitus prescribed DPP‐4i or SGLT2i at least
Ye‐Jee Kim, Yun Kyung Cho, Mi‐Sook Kim, Joongyub Lee, Seonghae Kim, Bo Ram Yang   +5 more
wiley   +1 more source

Comparative Study of Laboratory Diets for Piophila casei: Beneficial Effects of Infant Formula Supplementation

Entomologia Experimentalis et Applicata, EarlyView.
The infant formula‐based diet (F), the whole powder milk diet (P), and dry‐cured ham (H) were evaluated for rearing Piophila casei. H accelerated development, promoted earlier reproduction, and achieved the highest demographic performance but showed practical limitations linked to substrate deterioration. F enhanced larval survival and adult longevity,
Diletta Missere, Maria Luisa Dindo, Antonio Martini, Alberto Lanzoni   +3 more
wiley   +1 more source

Modulation of Inflammatory Indices by Omega-3 Fatty Acids Supplementation in Hemodialysis: A Clinical Trial Approach. [PDF]

Clin Transl Sci
Shafaei Kachaei H, Abbasi Mobarakrh K, Azaryan F, Torkaman M, Askarpour SA, Harsini AR, Fahimzad FS, Mousavi Mele M, Hoseinzadeh Liavoli M, Masoomi Golujeh N, Ataie Kashki S, Khoshdooz S, Doaei S, Khosravi M, Gholamalizadeh M.   +14 more
europepmc   +1 more source

Dietary fish oil improves intestinal barrier function and intestinal microbiota composition and reduces systemic inflammation in a mouse model of moderate acute malnutrition. [PDF]

J Nutr Sci
Patterson GE, Osorio EY, Dann SM, Melby PC.   +3 more
europepmc   +1 more source

Short-, medium-, versus long-chain fatty acids: mechanisms of immunomodulation and disease pathogenesis. [PDF]

Cell Mol Immunol
Kim CH.
europepmc   +1 more source