Results 61 to 70 of about 19,747,254 (371)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The role of fatty acids in attention deficit hyperactivity disorder
Acta Medica Alanya, 2022 Attention deficit hyperactivity disorder (ADHD) is a childhood-onset disorder that affects 5% to 12% of children worldwide. Etiological factors, including nutrition, contribute to this disease, which is characterized by inattention, impulsivity and ...
Fatih Gültekin +2 more
doaj +1 more source
, 2002 Optical conductivity spectra $\sigma_1(\omega)$ of paramagnetic CaRuO$_3$ are investigated at various temperatures. At T=10 K, it shows a non-Fermi liquid behavior of $\sigma_1(\omega)\sim 1/{\omega}^{\frac 12}$, similar to the case of a ferromagnet ...
A. Gold +29 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
IDENTIFICATION OF PHYTOPLANKTON TYPES IN TAMBAK BANDENG WITH HIGH QUALITY OF OMEGA-3
JFMR-Journal of Fisheries and Marine Research, 2019 Microalgae as a source of nutrients, can be a good alternative to the use of high-level organisms. The abundant omega 3 content in plankton, especially phytoplankton, needs to be conducted research on the identification of the types of phytoplankton in ...
Endang Yuli Herawati
doaj +1 more source
Scale-dependent correction to the dynamical conductivity of a disordered system at unitary symmetry
, 2012 Anderson localization has been studied extensively for more than half a century. However, while our understanding has been greatly enhanced by calculations based on a small epsilon expansion in d = 2 + epsilon dimensions in the framework of non-linear ...
Muttalib, K. A. +3 more
core +1 more source
Nutrients, 2019 The omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA), eicosapentaenoic (EPA, 20:5n-3) and docosahexaenoic (DHA, 22:6n-3) acids, are well accepted as being essential components of a healthy, balanced diet, having beneficial effects on ...
D. Tocher +4 more
semanticscholar +1 more source
Potential benefits and risks of omega-3 fatty acids supplementation to patients with COVID-19
Free Radical Biology & Medicine, 2020 Studies have shown that infection, excessive coagulation, cytokine storm, leukopenia, lymphopenia, hypoxemia and oxidative stress have also been observed in critically ill Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) patients in addition ...
M. Rogero +7 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
, 2014 It is known that the $(2k-1)$-sphere has at most $2^{O(n^k \log n)}$ combinatorially distinct triangulations with $n$ vertices, for every $k\ge 2$. Here we construct at least $2^{\Omega(n^k)}$ such triangulations, improving on the previous constructions ...
Nevo, Eran +2 more
core +1 more source