Advances in the design and development of oncolytic measles viruses. [PDF]
, 2015 A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian +2 more
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The impact of innate immune response on the efficacy of oncolytic viruses
Вопросы вирусологииOncolytic viruses represent a promising class of immunotherapeutic agents for the treatment of malignant tumors. The proposed mechanism of action of various oncolytic viruses has initially been explained by the ability of such viruses to selectively lyse
Kirill N. Trachuk +3 more
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Adenovirus-Mediated Sensitization to the Cytotoxic Drugs Docetaxel and Mitoxantrone Is Dependent on Regulatory Domains in the E1ACR1 Gene-Region [PDF]
, 2012 Oncolytic adenoviruses have shown promising efficacy in clinical trials targeting prostate cancers that frequently develop resistance to all current therapies.
Daniel Öberg +7 more
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Oncolytic Viruses in Bladder Cancer: Old Idea to Modern Approach [PDF]
Translational Research in Urology, 2022 Some viruses can infect and kill cancer cells. These viruses are known as oncolytic viruses (Virotherapy). The idea of killing cancer cells by oncolytic viruses mainly back to the old idea in the 19th (nineteenth) century. Scientists observed cancer cure
Kayhan Azadmanesh +2 more
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Oncolytic Virotherapy for Cancer: Clinical Experience
Biomedicines, 2021 Oncolytic viruses are a new class of therapeutics which are largely in the experimental stage, with just one virus approved by the FDA thus far. While the concept of oncolytic virotherapy is not new, advancements in the fields of molecular biology and ...
Shyambabu Chaurasiya +2 more
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Advances in oncolytic herpes simplex virus and adenovirus therapy for recurrent glioma
Frontiers in Immunology, 2023 Recurrent glioma treatment is challenging due to molecular heterogeneity and treatment resistance commonly observed in these tumors. Researchers are actively pursuing new therapeutic strategies.
Mingming Hu +7 more
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Clinical Trials of Oncolytic Viruses in Breast Cancer
Frontiers in Oncology, 2021 Breast cancer is the second most common kind of cancer worldwide and oncolytic viruses may offer a new treatment approach. There are three different types of oncolytic viruses used in clinical trials; (i) oncolytic viruses with natural anti-neoplastic ...
Mary E. Carter +3 more
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Oncolytic Viruses: Immunotherapy Drugs for Gastrointestinal Malignant Tumors
Frontiers in Cellular and Infection Microbiology, 2022 Oncolytic virus therapy has advanced rapidly in recent years. Natural or transgenic viruses can target tumor cells and inhibit tumor growth and metastasis in various ways without interfering with normal cell and tissue function.
Qingbo Li +9 more
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Study of Oncolytic Virus Preservation and Formulation
Pharmaceuticals, 2023 In recent years, oncolytic viruses (OVs) have emerged as an effective means of treating cancer. OVs have multiple oncotherapeutic functions including specifically infecting and lysing tumor cells, initiating immune cell death, attacking and destroying ...
Lina Pan +6 more
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Oncolytic viruses expressing MATEs facilitate target-independent T-cell activation in tumors. [PDF]
EMBO Mol MedPeter M +12 more
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