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Combination of oncolytic viruses and immune checkpoint inhibitors for treatment of high-grade gliomas [PDF]
Frontiers in NeurologyHigh-grade gliomas (HGG) such as glioblastoma are the most aggressive primary malignancies of the central nervous system. The median overall survival of glioblastoma is <15 months despite treatment with surgery, radiotherapy, and chemotherapy ...
Zhihong Qian +4 more
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Oncolytic Viruses in Bladder Cancer: Old Idea to Modern Approach [PDF]
Translational Research in Urology, 2022 Some viruses can infect and kill cancer cells. These viruses are known as oncolytic viruses (Virotherapy). The idea of killing cancer cells by oncolytic viruses mainly back to the old idea in the 19th (nineteenth) century. Scientists observed cancer cure
Kayhan Azadmanesh +2 more
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Oncolytic Virotherapy for Cancer: Clinical Experience
Biomedicines, 2021 Oncolytic viruses are a new class of therapeutics which are largely in the experimental stage, with just one virus approved by the FDA thus far. While the concept of oncolytic virotherapy is not new, advancements in the fields of molecular biology and ...
Shyambabu Chaurasiya +2 more
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Advances in oncolytic herpes simplex virus and adenovirus therapy for recurrent glioma
Frontiers in Immunology, 2023 Recurrent glioma treatment is challenging due to molecular heterogeneity and treatment resistance commonly observed in these tumors. Researchers are actively pursuing new therapeutic strategies.
Mingming Hu +7 more
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Clinical Trials of Oncolytic Viruses in Breast Cancer
Frontiers in Oncology, 2021 Breast cancer is the second most common kind of cancer worldwide and oncolytic viruses may offer a new treatment approach. There are three different types of oncolytic viruses used in clinical trials; (i) oncolytic viruses with natural anti-neoplastic ...
Mary E. Carter +3 more
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Oncolytic Viruses: Immunotherapy Drugs for Gastrointestinal Malignant Tumors
Frontiers in Cellular and Infection Microbiology, 2022 Oncolytic virus therapy has advanced rapidly in recent years. Natural or transgenic viruses can target tumor cells and inhibit tumor growth and metastasis in various ways without interfering with normal cell and tissue function.
Qingbo Li +9 more
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Study of Oncolytic Virus Preservation and Formulation
Pharmaceuticals, 2023 In recent years, oncolytic viruses (OVs) have emerged as an effective means of treating cancer. OVs have multiple oncotherapeutic functions including specifically infecting and lysing tumor cells, initiating immune cell death, attacking and destroying ...
Lina Pan +6 more
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Frontiers in Molecular Biosciences, 2022 Background: Although several oncolytic viruses have already been tested in early-stage clinical studies of breast cancer, there is still an urgent need to develop patient-derived experimental systems that mimic the response of breast cancer to oncolytic ...
Mary E. Carter +9 more
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Molecular Therapy: Oncolytics, 2016 To target oncolytic measles viruses (MV) to tumors, we exploit the binding specificity of designed ankyrin repeat proteins (DARPins). These DARPin-MVs have high tumor selectivity while maintaining excellent oncolytic potency.
Jan RH Hanauer +15 more
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Infection of non-cancer cells: A barrier or support for oncolytic virotherapy?
Molecular Therapy: Oncolytics, 2022 Oncolytic viruses are designed to specifically target cancer cells, sparing normal cells. Although numerous studies demonstrate the ability of oncolytic viruses to infect a wide range of non-tumor cells, the significance of this phenomenon for cancer ...
Victor A. Naumenko +4 more
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