Results 101 to 110 of about 31,178 (269)
Mathematical Modeling of the Role of Cytokines in Sindbis Virus Treatment of Glioblastoma
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.ABSTRACT Oncolytic viruses, specifically Sindbis virus (SINV), combined with cytokines show promising results in slowing glioma progression, but a quantitative understanding of their effects remains limited. In this study, we use an ordinary differential equation (ODE) model to examine the effect of adding cytokines to oncolytic SINV therapy.
Shriya Makam, Hana M. Dobrovolny
wiley +1 more source
Oncolytic Adenovirus-Induced Autophagy: Tumor-Suppressive Effect and Molecular Basis [PDF]
, 2013 Autophagy is a catabolic process that produces energy through lysosomal degradation of intracellular organelles. Autophagy functions as a cytoprotective factor under physiological conditions such as nutrient deprivation, hypoxia, and interruption of ...
Fujiwara, Toshiyoshi +2 more
core +1 more source
Oncolytic Viruses and Immune Checkpoint Inhibition: The Best of Both Worlds
Molecular Therapy: Oncolytics, 2019 Cancer immunotherapy and the emergence of immune checkpoint inhibitors have markedly changed the treatment paradigm for many cancers. They function to disrupt cancer cell evasion of the immune response and activate sustained anti-tumor immunity ...
Venkatesh Sivanandam +4 more
doaj +1 more source
Rational engineering of microRNA-regulated viruses for cancer gene therapy [PDF]
, 2013 MicroRNAs (miRNAs) are small noncoding RNA molecules that have important regulatory roles in a wide range of biological processes. miRNAs are often expressed in a tissue- and/or differentiation state-specific patterns, and it is estimated that miRNAs can
Ylösmäki, Erkko
core
Oncolytic viruses in cancer therapy
Cancer Letters, 2007 Oncolytic virotherapy is a promising form of gene therapy for cancer, employing nature's own agents to find and destroy malignant cells. The purpose of this review is to provide an introduction to this very topical field of research and to point out some of the current observations, insights and ideas circulating in the literature.
Vähä-Koskela, Markus J.V. +2 more
openaire +2 more sources
Exploiting tumor epigenetics to improve oncolytic virotherapy [PDF]
, 2013 Oncolytic viruses (OVs) comprise a versatile and multi-mechanistic therapeutic platform in the growing arsenal of anticancer biologics. These replicating therapeutics find favorable conditions in the tumor niche, characterized among others by increased ...
Hesham Abdelbary +4 more
core +1 more source
Cells, 2018 Oncolytic virus therapy of cancer is an actively pursued field of research. Viruses that were once considered as pathogens threatening the wellbeing of humans and animals alike are with every passing decade more prominently regarded as vehicles for ...
Tereza Brachtlova +1 more
doaj +1 more source
Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
Fan Liu, Lei Xiong, Xia Yu, Mingfang Ji
wiley +1 more source
Pharmacological modulation of anti-tumor immunity induced by oncolytic viruses
Frontiers in Oncology, 2014 Oncolytic viruses kill cancer cells by direct lysis but also generate a significant anti-tumor immune response that allows for prolonged cancer control and in some cases cures.
Nicole E. Forbes +5 more
doaj +1 more source