Results 21 to 30 of about 15,940 (198)
Oncolytic viruses: finally delivering [PDF]
British Journal of Cancer, 2016 Oncolytic viruses can be found at the confluence of virology, genetic engineering and pharmacology where versatile platforms for molecularly targeted anticancer agents can be designed and optimised. Oncolytic viruses offer several important advantages over traditional approaches, including the following.
Seymour, Leonard W, Fisher, Kerry D
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Tumor Tropism of DNA Viruses for Oncolytic Virotherapy
Viruses, 2023 Oncolytic viruses (OVs) have emerged as one of the most promising cancer immunotherapy agents that selectively target and kill cancer cells while sparing normal cells. OVs are from diverse families of viruses and can possess either a DNA or an RNA genome.
Junior A. Enow +2 more
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Oncolytic Viruses as Anticancer Vaccines [PDF]
Frontiers in Oncology, 2014 Oncolytic virotherapy has shown impressive results in preclinical studies and first promising therapeutic outcomes in clinical trials as well. Since viruses are known for a long time as excellent vaccination agents, oncolytic viruses are now designed as novel anticancer agents combining the aspect of lysis-dependent cytoreductive activity with ...
Woller, Norman +4 more
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CRISPR-Cas9 as a Powerful Tool for Efficient Creation of Oncolytic Viruses
Viruses, 2016 The development of oncolytic viruses has led to an emerging new class of cancer therapeutics. Although the safety profile has been encouraging, the transition of oncolytic viruses to the clinical setting has been a slow process due to modifications ...
Ming Yuan +3 more
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Oncolytic Viruses for Malignant Glioma: On the Verge of Success?
Viruses, 2021 Glioblastoma is one of the most difficult tumor types to treat with conventional therapy options like tumor debulking and chemo- and radiotherapy.
Yogesh R. Suryawanshi, Autumn J. Schulze
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Designing and Building Oncolytic Viruses [PDF]
Future Virology, 2017 Oncolytic viruses (OVs) are engineered and/or evolved to propagate selectively in cancerous tissues. They have a dual mechanism of action; direct killing of infected cancer cells cross-primes anticancer immunity to boost the killing of uninfected cancer cells.
Maroun, Justin +5 more
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Oncolytic effects of a novel influenza A virus expressing interleukin-15 from the NS reading frame. [PDF]
PLoS ONE, 2012 Oncolytic influenza A viruses with deleted NS1 gene (delNS1) replicate selectively in tumour cells with defective interferon response and/or activated Ras/Raf/MEK/ERK signalling pathway.
Marijke van Rikxoort +7 more
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Comprehensive assessment on the applications of oncolytic viruses for cancer immunotherapy
Frontiers in Pharmacology, 2022 The worldwide burden of cancers is increasing at a very high rate, including the aggressive and resistant forms of cancers. Certain levels of breakthrough have been achieved with the conventional treatment methods being used to treat different forms of ...
Richard Kolade Omole +14 more
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The current status of oncolytic viral therapy for head and neck cancer
World Journal of Otorhinolaryngology-Head and Neck Surgery, 2016 Objective: Cancer affects the head and neck region frequently and leads to significant morbidity and mortality. Oncolytic viral therapy has the potential to make a big impact in cancers that affect the head and neck. We intend to review the current state
Matthew O. Old +4 more
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Oncolytic viruses and pancreatic cancer
Cancer Treatment and Research Communications, 2022 Today, the pancreatic cancer prognosis is poor and genetic technology is developing to treat various types of cancers. Scientists are actively looking for a new technique to design a therapeutic strategy to treat pancreatic cancer. Several oncolytic viruses are known to be valuable tools for pancreatic cancer treatment. Recent Studies demonstrate their
Vahideh Hamidi-Sofiani +5 more
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