Results 51 to 60 of about 252,434 (288)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Open Educational Practices Advocacy: The Instructional Designer Experience

Canadian Journal of Learning and Technology, 2020
Instructional designers are in a unique position to provide leadership and support for advancement of new technologies and practices. There is a paucity of research on current and potential roles of Instructional designers in incorporating and advocating
Michelle Harrison, Irwin DeVries
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Quali scenari per le pratiche e-learning nell’università? Gli “Open Educational Path”

Lea, 2014
E-learning for over fifteen years has evolved from a simple instrument for virtual educational interactions (1.0) to an environment capable of promoting wide participatory experiences (2.0).
Antonio Calvani Laura Menichetti
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The case for open educational practice [PDF]

Distance Education, 2016
In his recent book The Battle for Open: How Openness Won and Why it Doesn’t Feel Like Victory, Weller (2014) explores why despite the considerable gains made in relation to advocacy, funding and po...
openaire   +1 more source

An Open Networking Lab for practical open education [PDF]

, 2019
The Cisco Networking Academy programme (NetAcad) supports education and training in network engineering worldwide. NetAcad works with diverse educational institutions to offer an educational ‘vertical’ from beginner to advanced network engineer. However, as recognised by employment stakeholders, skills shortages in networking remain (Tech Partnership ...
Kear, Karen, Smith, Andrew, Donelan, Helen, Mikroyannidis, Alexander, Jones, Allan, Rosewell, Jonathan, Wermelinger, Michel, Connolly, Teresa, Sanders, Chris, Peasgood, Alice, Williams, Judith, Moss, Nicky, Third, Allan   +12 more
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Open Educational Practices in den Rechtswissenschaften

Bibliothek
Der vorliegende Beitrag stellt die wissenschaftsgeleitete Initiative „OpenRewi“ vor, die in den Rechtswissenschaften durch Open Educational Practices Open Science fördert.
Ramson Lasse, Schneeberger Charlotte, Schulz Katharina   +2 more
doaj   +1 more source