Results 71 to 80 of about 252,434 (288)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

From OER to OEP: shifting practitioner perspectives and practices with innovative learning experience design

open access: yes, 2015
Like any other educational resource, the integration of OER in teaching and learning requires careful thought and support for the teaching staff. The Faculty of Education at the Open University of Sri Lanka approached this challenge with the help of a ...
Ratnayake, H.U.W.   +7 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Spectrum Of Open Education Practices

open access: yes, 2018
Spektrum offener Praktiken in Lehre und Bildung. Werkzeuge passen gegebenenfalls auf mehr als einen Anwendungsfall, sind aber nur einmal gelistet. Rainbow of open practices in teaching and education available as png, pdf, ps, ai & eps for anyone to reuse. Tools may support more than 1 practice, but are listed only once.
Euler, Ellen, Poupart, Raoul
openaire   +1 more source

Learning from the innovative open practices of three international health projects: IACAPAP, VCPH and Physiopedia [PDF]

open access: yes, 2015
Open educational resources and open educational practices are being increasingly used around the globe to train and support professionals in areas where funding and resources are scarce.
Leigh-Anne Perryman   +3 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

A Qualitative Inquiry of K–12 Teachers’ Experience with Open Educational Practices: Perceived Benefits and Barriers of Implementing Open Educational Resources

open access: yesInternational Review of Research in Open and Distributed Learning, 2020
Teachers in K–12 schools have shown an increasing desire for open educational resources (OER) to ensure all students can learn effectively. OER provide teachers with free access to open-licensed educational resources that they can retain, reuse, revise ...
Hengtao Tang
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

2017 Open and Distance Learning Association of Australia Conference: Expanding Horizons in Open & Distance Learning: Openness, Community, Innovation. [PDF]

open access: yes, 2017
Open Educational Practices (OEP) have been playing an important role in assisting higher education sectors and governments worldwide to meet their current and future educational targets in widening participation, lowering costs, improving the quality of ...
Stagg, Adrian, Bossu, Carina
core  

Obstacles to creating and finding Open Educational Resources: the case of research methods in the social sciences

open access: yes, 2012
Social Research Methods are approaches to undertaking research shared not only by the social sciences, but by many other disciplines. There is therefore enormous scope for the creation and re-use of open educational resources (OERs) in this field ...
Gibbs, Graham R.   +6 more
core   +1 more source

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