Results 61 to 70 of about 20,883,039 (279)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
On the map: towards a multidimensional understanding of Open Educational Practices [PDF]
, 2018 In the context of contemporary higher education, the concept of Open Education has come to be closely associated with technology-enabled approaches, particularly the creation, sharing and repurposing of Open Educational Resources (OER), and the ...
Marsh, J.D. +4 more
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Practicalities of implementing open pedagogy in higher education [PDF]
Smart Learning Environments, 2019 AbstractThis paper presents findings from a study which explored the ways in which post-secondary educators in British Columbia are reforming their teaching and learning practice as result of open education. Using a phenomenological approach with self-identifying open education practitioners we explore how openness is being enacted through learning ...
Michael Paskevicius, Valerie Irvine
openaire +3 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Educational policy and open educational practice in Australian higher education [PDF]
, 2016 Open Educational Policy has become increasingly the subject of government attention globally, primarily with a focus on reducing educational costs for tax payers.
Stagg, Adrian, Bossu, Carina
core +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Open education practices in higher education [PDF]
, 2018 Reikšminiai žodžiai: Atvira švietimo praktika; Atviri švietimo ištekliai; Atvirieji švietimo ištekliai; Atvirojo švietimo praktika; Aukštasis mokslas; Kokybinis mokymas; Prieiga prie išteklių, naujovės; Access to resources; Higher education; Innovation; Open Educational Practices; Open Educational Resources; Quality ...
Ehlers, Ulf-Daniel +3 more
openaire +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source