Results 51 to 60 of about 20,813,812 (244)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Development of an Open Educational Resource for Fundamentals of Communication

Teaching and Learning Excellence through Scholarship
The use of Open Educational Resources (OERs) across higher education is on the rise. In a survey of higher education faculty across the U.S. 33% of respondents reported using an OER for the 2024-2025 school year. This is up from 15% just 5 years earlier
Sheri A. Trivane
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Open data as open educational resources: case studies of emerging practice

, 2015
This post marks the official publication of the volume: Open Data as Open Educational Resources: Case studies of emerging ...
Atenas, Javiera, Havemann, Leo, Javiera Atenas (413831), Leo Havemann (593219), Atenas, J.   +4 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

EdTechnica: a vision of an educational publishing community of practice that is accessible, flexible, and just

International Journal of Educational Technology in Higher Education
Open Educational Resources (OER) and Open Educational Practices (OEP) have the potential to transform and positively impact individuals, institutions, and society.
Bohdana Allman, Royce Kimmons, Camille Dickson-Deane, Aras Bozkurt, Melissa Warr, Jill Stefaniak, Monalisa Dash, Fanny Eliza Bondah   +7 more
doaj   +1 more source

Smartphone and Tablet-Based Sensing of Environmental Radioactivity: Mobile Low-Cost Measurements for Monitoring, Citizen Science, and Educational Purposes

Sensors, 2019
Sensors for environmental radioactivity based on two novel setups using photodiodes, on the one hand, and an advanced tablet-based hybrid pixel detector, on the other hand, are presented.
Oliver Keller, Mathieu Benoit, Andreas Müller, Sascha Schmeling   +3 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Open Educational Resources: Conversations in Cyberspace [PDF]

, 2009
Education systems today face two major challenges: expanding the reach of education and improving its quality. Traditional solutions will not suffice, especially in the context of today's knowledge-intensive societies.The goal of the Open Educational ...
Catriona Savage, Savage, Catriona, Susan D'Antoni, D'Antoni, Susan   +3 more
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