Results 141 to 150 of about 1,069,344 (328)

Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez, Núria Gaja‐Capdevila, Laura Mosqueira‐Martín, Mireia Herrando‐Grabulosa, Laura Rodriguez‐Gomez, Klaudia Gonzalez‐Imaz, Ana C. Calvo, Maialen Sagartzazu‐Aizpurua, Leticia Moreno‐García, Jose Manuel Fuentes, Abraham Acevedo‐Arozena, Jesús María Aizpurua, José Ignacio Miranda, Adolfo López de Munain, Ainara Vallejo‐Illarramendi, Xavier Navarro, Rosario Osta, Francisco Javier Gil‐Bea   +17 more
wiley   +1 more source

Interleukin-4 Induces the Release of Opioid Peptides from M1 Macrophages in Pathological Pain. [PDF]

J Neurosci, 2021
Labuz D, Celik MÖ, Seitz V, Machelska H.   +3 more
europepmc   +1 more source

Identifying Spatiotemporal Patterns in Opioid Vulnerability: Investigating the Links Between Disability, Prescription Opioids and Opioid-Related Mortality [PDF]

arXiv
The opioid crisis remains one of the most daunting and complex public health problems in the United States. This study investigates the national epidemic by analyzing vulnerability profiles of three key factors: opioid-related mortality rates, opioid prescription dispensing rates, and disability rank ordered rates. This study utilizes county level data,
arxiv  

Survey on 9 years of anti‐doping controls in horse races in Italy

Equine Veterinary Journal, EarlyView.
Abstract Background Doping in racehorses is a threat to horse welfare and the integrity of the sport. Despite its relevance, the literature on the prevalence of anti‐doping violations worldwide is limited. Objectives To analyse anti‐doping violations in racehorses in Italy. Study Design Retrospective observational study.
Mariana Roccaro, Riccardo Rinnovati, Luca Stucchi, Federica La Rocca, Giuseppe Cascio, Angelo Peli   +5 more
wiley   +1 more source

d‐amino acids: new functional insights

The FEBS Journal, EarlyView.
This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni, Natasa Kustrimovic, Luciano Piubelli, Elena Rosini, Valentina Rabattoni, Silvia Sacchi   +5 more
wiley   +1 more source

Safety and tolerability of ubrogepant for the acute treatment of migraine in participants taking atogepant for the preventive treatment of episodic migraine: Results from the TANDEM study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To evaluate the safety and tolerability of ubrogepant for the acute treatment of migraine in participants taking atogepant for the preventive treatment of episodic migraine (EM). Background Atogepant is an oral calcitonin gene‐related peptide (CGRP) receptor antagonist approved for the preventive treatment of migraine in adults and ...
Jessica Ailani, Richard B. Lipton, Andrew M. Blumenfeld, Laszlo Mechtler, Brad C. Klein, Molly Yizeng He, Jonathan H. Smith, Joel M. Trugman, Rosa de Abreu Ferreira, Elimor Brand‐Schieber   +9 more
wiley   +1 more source

Effect of erenumab versus other migraine preventive medications on cardiovascular and cerebrovascular outcomes: A United States claims database‐based observational cohort study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To estimate the real‐world risk of cardiovascular events among patients with migraine treated with erenumab and other migraine preventive medications. Background Migraine preventive treatment with calcitonin gene‐related peptide (CGRP) pathway inhibitors, such as erenumab and others, may theoretically result in cardiovascular effects
David W. Dodick, Stewart J. Tepper, Jessica Ailani, Ani C. Khodavirdi, Nico Pannacciulli, Alan Fu, Shia T. Kent, Karminder Gill, Robert Urman, Sam S. Oh   +9 more
wiley   +1 more source

European S2k guidelines for hidradenitis suppurativa/acne inversa part 2: Treatment

Journal of the European Academy of Dermatology and Venereology, EarlyView.
HS treatment algorithm. Abstract Introduction This second part of the S2k guidelines is an update of the 2015 S1 European guidelines. Objective These guidelines aim to provide an accepted decision aid for the selection, implementation and assessment of appropriate and sufficient therapy for patients with hidradenitis suppurativa/acne inversa (HS ...
C. C. Zouboulis, F. G. Bechara, F. Benhadou, V. Bettoli, Z. Bukvić Mokos, V. Del Marmol, M. Dolenc‐Voljč, E. J. Giamarellos‐Bourboulis, Ø. Grimstad, P. Guillem, B. Horváth, R. E. Hunger, J. R. Ingram, D. Ioannidis, E. Just, L. Kemény, B. Kirby, A. I. Liakou, B. M. McGrath, A. V. Marzano, Ł. Matusiak, A. Molina‐Leyva, A. Nassif, M. Podda, E. P. Prens, F. Prignano, H. Raynal, M. Romanelli, D. M. L. Saunte, A. Szegedi, J. C. Szepietowski, T. Tzellos, S. Valiukevičienė, H. H. van der Zee, K. R. van Straalen, B. Villumsen, G. B. E. Jemec   +36 more
wiley   +1 more source

Common genetic variants do not impact clinical prediction of methotrexate treatment outcomes in early rheumatoid arthritis

Journal of Internal Medicine, EarlyView.
Abstract Background Methotrexate (MTX) is the mainstay initial treatment of rheumatoid arthritis (RA), but individual response varies and remains difficult to predict. The role of genetics remains unclear, but studies suggest its importance. Methods Incident RA patients starting MTX‐monotherapy were identified through a large‐scale Swedish register ...
Anton Öberg Sysojev, Bénédicte Delcoigne, Thomas Frisell, Lars Alfredsson, Lars Klareskog, The SRQ biobank group, Saedis Saevarsdottir, Magnus Boman, Leonid Padyukov, Johan Askling, Helga Westerlind   +10 more
wiley   +1 more source

Investigating the importance of social vulnerability in opioid-related mortality across the United States [PDF]

arXiv
The opioid crisis remains a critical public health challenge in the United States. Despite national efforts to reduce opioid prescribing rates by nearly 45\% between 2011 and 2021, opioid overdose deaths more than tripled during this same period. This alarming trend reflects a major shift in the crisis, with illegal opioids now driving the majority of ...
arxiv