Results 141 to 150 of about 1,091,339 (232)
Strategies to deliver peptide drugs to the brain [PDF]
Lalatsa, Katerina+2 more
core +1 more source
The mysterious middlemen making your vision pop: understanding the function of amacrine cells
Abstract figure legend This review aims to illustrate the diversity and function of amacrine cells in the retina. The diversity of amacrine cell subtypes is depicted based on morphology, stratification and neurotransmitter expression, along with their synaptic connectivity with bipolar and ganglion cells, emphasizing inhibitory and modulatory roles ...
Victor Calbiague‐Garcia+3 more
wiley +1 more source
Advancements in Ambient Ionisation Mass Spectrometry in 2024: An Annual Review
ABSTRACT The introduction of ambient ionisation mass spectrometry (AIMS) is among the most important developments in analytical chemistry in recent years. Enabling the direct analysis of samples in their native state with neither sample preparation nor chromatographic separation provides chemical characterisation in a matter of seconds.
Alisha Henderson+2 more
wiley +1 more source
Dynorphin and Enkephalin Opioid Peptides and Transcripts in Spinal Cord and Dorsal Root Ganglion During Peripheral Inflammatory Hyperalgesia and Allodynia. [PDF]
Sapio MR+7 more
europepmc +1 more source
Degenerated painful discs present with mechanical instability, inflammation, and nerve sprouting, however, patients treated with spinal stabilizing procedures often report pain alleviation indicating spinal mechanics, could be causative in the production of pain.
David J. Lillyman+4 more
wiley +1 more source
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez+17 more
wiley +1 more source
The study focused on a mouse model of depression induced by lipopolysaccharides (LPS) and employed innovative multi‐omics approaches, including two‐dimensional gel electrophoresis (2‐DE) for proteomics, liquid chromatography–mass spectrometry (LC–MS) for metabolomics, and real‐time polymerase chain reaction (PCR) microarray technology to analyze the ...
Wen‐Wen Li+10 more
wiley +1 more source
Spexin exhibits a therapeutic effect in ulcerative colitis. Spexin suppresses oxidative damage and neutrophil infiltration in the acetic acid induced ulcerative colitis rat model. Spexin reduces inflammation in ulcerative colitis by inhibiting the NLRP3 inflammasome pathway. Spexin suppresses the NF‐κB‐mediated increase in pro‐inflammatory cytokines in
Sevil Arabacı Tamer+4 more
wiley +1 more source
Effects of Central Administration of Opioid Peptides, Vasotocin, Mesotocin, and Corticotrophin-Releasing Factor on Water Intake in Chicks. [PDF]
Zhang Y+4 more
europepmc +1 more source
GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases
Within the GABAergic system, GABABRs are potential therapeutic targets for dealing multiple metabolic and binge eating disorders and food addiction. Allosteric modulators and small peptides targeting GABABR signaling pathways may be developed as attractive drug candidates that avoid the side effects of agents that directly bind these receptors ...
Weijie Xie+10 more
wiley +1 more source