Results 141 to 150 of about 1,091,339 (232)

Strategies to deliver peptide drugs to the brain [PDF]

open access: yes, 2014
Lalatsa, Katerina   +2 more
core   +1 more source

The mysterious middlemen making your vision pop: understanding the function of amacrine cells

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This review aims to illustrate the diversity and function of amacrine cells in the retina. The diversity of amacrine cell subtypes is depicted based on morphology, stratification and neurotransmitter expression, along with their synaptic connectivity with bipolar and ganglion cells, emphasizing inhibitory and modulatory roles ...
Victor Calbiague‐Garcia   +3 more
wiley   +1 more source

Advancements in Ambient Ionisation Mass Spectrometry in 2024: An Annual Review

open access: yesAnalytical Science Advances, Volume 6, Issue 1, June 2025.
ABSTRACT The introduction of ambient ionisation mass spectrometry (AIMS) is among the most important developments in analytical chemistry in recent years. Enabling the direct analysis of samples in their native state with neither sample preparation nor chromatographic separation provides chemical characterisation in a matter of seconds.
Alisha Henderson   +2 more
wiley   +1 more source

Dynorphin and Enkephalin Opioid Peptides and Transcripts in Spinal Cord and Dorsal Root Ganglion During Peripheral Inflammatory Hyperalgesia and Allodynia. [PDF]

open access: yesJ Pain, 2020
Sapio MR   +7 more
europepmc   +1 more source

An Extracellular Matrix Hydrogel Restores Disc Volume and Alleviates Axial Hypersensitivity in a Rat Model of Disc‐Associated Pain

open access: yesJOR SPINE, Volume 8, Issue 2, June 2025.
Degenerated painful discs present with mechanical instability, inflammation, and nerve sprouting, however, patients treated with spinal stabilizing procedures often report pain alleviation indicating spinal mechanics, could be causative in the production of pain.
David J. Lillyman   +4 more
wiley   +1 more source

Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 11, Page 2466-2486, June 2025.
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez   +17 more
wiley   +1 more source

Multi‐Omics Analysis Reveals Disturbances of Purine Metabolism and Glutamate Metabolism in the Hippocampus of Lipopolysaccharide‐Induced Mouse Model of Depression

open access: yesBrain and Behavior, Volume 15, Issue 5, May 2025.
The study focused on a mouse model of depression induced by lipopolysaccharides (LPS) and employed innovative multi‐omics approaches, including two‐dimensional gel electrophoresis (2‐DE) for proteomics, liquid chromatography–mass spectrometry (LC–MS) for metabolomics, and real‐time polymerase chain reaction (PCR) microarray technology to analyze the ...
Wen‐Wen Li   +10 more
wiley   +1 more source

Anti‐Inflammatory Effects of Spexin on Acetic Acid‑Induced Colitis in Rats via Modulating the NF‐κB/NLRP3 Inflammasome Pathway

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 39, Issue 5, May 2025.
Spexin exhibits a therapeutic effect in ulcerative colitis. Spexin suppresses oxidative damage and neutrophil infiltration in the acetic acid induced ulcerative colitis rat model. Spexin reduces inflammation in ulcerative colitis by inhibiting the NLRP3 inflammasome pathway. Spexin suppresses the NF‐κB‐mediated increase in pro‐inflammatory cytokines in
Sevil Arabacı Tamer   +4 more
wiley   +1 more source

GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases

open access: yesMedComm, Volume 6, Issue 5, May 2025.
Within the GABAergic system, GABABRs are potential therapeutic targets for dealing multiple metabolic and binge eating disorders and food addiction. Allosteric modulators and small peptides targeting GABABR signaling pathways may be developed as attractive drug candidates that avoid the side effects of agents that directly bind these receptors ...
Weijie Xie   +10 more
wiley   +1 more source

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