Results 41 to 50 of about 1,088,006 (377)
Diabetology & Metabolic Syndrome, 2021 Background Prediabetes is characterized by a hemoglobin A1c of 5.7–6.4% and fasting blood glucose of 100–125 mg/dl. A high percentage of prediabetes subjects develop type 2 diabetes mellitus in the next years.
Shatha Rouf Moustafa
doaj +1 more source
Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]
, 2013 Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Birkás, Erika +12 more
core +3 more sources
A review of frequently used Kampo prescriptions part 1. Daikenchuto
Traditional &Kampo Medicine, Volume 9, Issue 3, Page 151-179, December 2022., 2022 Abstract Background The original formula name for daikenchuto (DKT) was written in ‘Jin Gui Yao Lue (Kinkiyōryaku in Japanese)’. DKT as used in Japan consists of four types of crude drug. Key findings Although there are few examples of its use in Chinese classical records, it has begun to be used extensively in modern Japan for intestinal obstruction ...
Takao Namiki +5 more
wiley +1 more source
Role of food-derived opioid peptides in the central nervous and gastrointestinal systems.
Journal of food biochemistry, 2018 Opioid receptors are widely distributed in central nervous system and peripheral tissues. Endogenous opioid receptor ligands are involved in many physiological processes.
Zhen-ze Liu, Chibuike C. Udenigwe
semanticscholar +1 more source
Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions
Frontiers in Pharmacology, 2013 Mechanisms of endogenous pain control are significant. Increasing studies have clearly produced evidence for the clinical usefulness of opioids in peripheral analgesia.
Katerina eIwaszkiewicz +2 more
doaj +1 more source
Opioid modulation of GABA release in the rat inferior colliculus [PDF]
, 2004 Background: The inferior colliculus, which receives almost all ascending and descending auditory signals, plays a crucial role in the processing of auditory information.
Casalotti, SO +7 more
core +3 more sources
Endogenous opioids in wound-site neutrophils of sternotomy patients. [PDF]
PLoS ONE, 2012 Postoperative pain management is a critical aspect of patient care. The inflammatory state of the post-sternotomy surgical wound sensitizes nerve endings, causing pain. Unrelieved or improperly managed pain compromises wound healing.
Hamdy Awad +8 more
doaj +1 more source
eLife, 2021 Many signal transduction systems have an apparent redundancy built into them, where multiple physiological agonists activate the same receptors. Whether this is true redundancy, or whether this provides an as-yet unrecognized specificity in downstream ...
Jennifer M Kunselman +4 more
doaj +1 more source
Opioid receptors in GtoPdb v.2021.3 [PDF]
, 2021 Opioid and opioid-like receptors are activated by a variety of endogenous peptides including [Met]enkephalin (met), [Leu]enkephalin (leu), β-endorphin (β-end), α-neodynorphin, dynorphin A (dynA), dynorphin B (dynB), big dynorphin (Big dyn),
Borsodi, Anna +29 more
core +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Opioids acting at the mu-opioid receptor (MOR) are the gold standard for pain relief. Unfortunately, these drugs have severe side effects, including addiction liability and respiratory depression.
R. Kandasamy +13 more
semanticscholar +1 more source