Results 41 to 50 of about 1,122,610 (333)
Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions
Frontiers in Pharmacology, 2013 Mechanisms of endogenous pain control are significant. Increasing studies have clearly produced evidence for the clinical usefulness of opioids in peripheral analgesia.
Katerina eIwaszkiewicz +2 more
doaj +1 more source
Endogenous peripheral pain regulatory systems in orofacial pain patients
Saudi Dental Journal, 2019 Introduction: Initiation of pulpal pain begins with the release of bacterial toxins and inflammatory mediators that either activate or sensitize nociceptors thereby activating the trigeminal pain pathway.
Abdulmajeed M. Al Shujaa +4 more
doaj +1 more source
Endogenous opioids in wound-site neutrophils of sternotomy patients. [PDF]
PLoS ONE, 2012 Postoperative pain management is a critical aspect of patient care. The inflammatory state of the post-sternotomy surgical wound sensitizes nerve endings, causing pain. Unrelieved or improperly managed pain compromises wound healing.
Hamdy Awad +8 more
doaj +1 more source
Role of food-derived opioid peptides in the central nervous and gastrointestinal systems.
Journal of food biochemistry, 2018 Opioid receptors are widely distributed in central nervous system and peripheral tissues. Endogenous opioid receptor ligands are involved in many physiological processes.
Zhenze Liu, Chibuike C. Udenigwe
semanticscholar +1 more source
Probing protein sequences as sources for encrypted antimicrobial peptides [PDF]
, 2012 Starting from the premise that a wealth of potentially biologically active peptides may lurk within proteins, we describe here a methodology to identify putative antimicrobial peptides encrypted in protein sequences.
Alan Cooper +8 more
core +7 more sources
Influence of opioid peptides on human neutrophil apoptosis and activation in vitro
Mediators of Inflammation, 2002 Background: It has been shown that cells of the immune system release opioid peptides and possess receptors for them. The concentrations of opioid peptides in the peripheral circulation rapidly increase during inflammation and acute stress response.
Zofia Sulowska +4 more
doaj +1 more source
In Silico and In Vitro Analysis of Multifunctionality of Animal Food-Derived Peptides
Foods, 2020 Currently, the associations between oxidative stress, inflammation, hypertension, and metabolic disturbances and non-communicable diseases are very well known.
Lourdes Amigo +2 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Opioids acting at the mu-opioid receptor (MOR) are the gold standard for pain relief. Unfortunately, these drugs have severe side effects, including addiction liability and respiratory depression.
R. Kandasamy +13 more
semanticscholar +1 more source
Molecules, 2020 The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo.
Ariana C. Brice-Tutt +7 more
doaj +1 more source
Peripherally Acting Opioids in Orofacial Pain
Frontiers in Neuroscience, 2021 The activation of opioid receptors by exogenous or endogenous opioids can produce significant analgesic effects in peripheral tissues. Numerous researchers have demonstrated the expression of peripheral opioid receptors (PORs) and endogenous opioid ...
Qing Liu +10 more
doaj +1 more source