Results 31 to 40 of about 469,418 (405)
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Combining ligand‐based and structure‐based methodologies, the applied virtual screening approach identified a collection of sulfonamides targeting the human carbonic anhydrase (hCA) VA isoform. 2‐(3,4‐Dihydro‐2H‐quinolin‐1‐yl)‐N‐(4‐sulfamoylphenyl)acetamide was identified as a potent and selective lead compound as a candidate for further exploitation ...
Laura De Luca +4 more
wiley +1 more source
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Based on a simplified version of the morphinan scaffold, 3‐[3‐(phenalkylamino)cyclohexyl]phenol analogues were designed, synthesized and evaluated for their µ‐opioid receptor (MOR) antagonist activity in vitro and in silico. Docking studies indicate a peculiar combination of C‐1 stereochemistry and N‐substitutions as feasibly essential for MOR‐ligand ...
Graziella Tocco +8 more
wiley +1 more source
Abuse and Diversion of Immediate Release Opioid Analgesics as Compared to Extended Release Formulations in the United States. [PDF]
PLoS ONE, 2016 Therapeutic use and abuse of prescription opioids in the United States increased substantially between 1990 and 2010. The Centers for Disease Control estimated deaths related to pharmaceutical opioids reached nearly 19,000 in 2014.
Janetta L Iwanicki +9 more
doaj +1 more source
BMJ Open, 2022 Objectives The rate of drug overdose deaths in the USA has more than tripled since the turn of the century, and rates are disproportionately high among the American Indian/Alaska Native (AI/AN) population.
Fares Qeadan +8 more
doaj +1 more source
Opioids and the immune system – friend or foe
British Journal of Pharmacology, 2018 Systemically administered opioids are among the most powerful analgesics for treating severe pain. Several negative side effects (respiratory depression, addiction, nausea and confusion) and the risk of opioid‐induced hyperalgesia accompany opioid ...
Lisanne Mirja Plein, H. Rittner
semanticscholar +1 more source
Endogenous and Exogenous Opioids in Pain.
Annual Review of Neuroscience, 2018 Opioids are the most commonly used and effective analgesic treatments for severe pain, but they have recently come under scrutiny owing to epidemic levels of abuse and overdose.
G. Corder +3 more
semanticscholar +1 more source
Journal of the American College of Emergency Physicians Open, 2022 Objective To quantify unused opioids among adult and pediatric patients discharged from the emergency department (ED) or ambulatory care settings with a prescription for acute pain.
Michele P. Dyson +6 more
doaj +1 more source
Safety of opioid patch initiation in Australian residential aged care [PDF]
, 2015 Explores opioid use by aged care facility residents before and after initiation of transdermal opioid patches. Abstract Objective: To explore opioid use by aged care facility residents before and after initiation of transdermal opioid patches. Design:
Elizabeth Roughead +2 more
core +1 more source
Factors related to the use of opioids as early treatment in patients with knee osteoarthritis
Arthritis Research & Therapy, 2019 Objective To examine factors related to the use of opioids as an early treatment option for knee OA patients Methods Using the Korean nationwide claim database, we selected knee OA patients between 2013 and 2015. Among them, patients without any claim of
Soo-Kyung Cho +7 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Introduction: Europe has seen a steady increase in the use of prescription opioids, especially in non-cancer indications. Epidemiological data on the patterns of use of opioids is required to optimize prescription.
Isabel Hurtado +15 more
doaj +1 more source