Results 31 to 40 of about 2,522,619 (179)

Intracellular Accumulation of Linezolid and Florfenicol in OptrA-Producing Enterococcus faecalis and Staphylococcus aureus [PDF]

Molecules, 2018
The optrA gene, which confers transferable resistance to oxazolidinones and phenicols, is defined as an ATP-binding cassette (ABC) transporter but lacks transmembrane domains. The resistance mechanism of optrA and whether it involves antibiotic efflux or
Yingyu Wang, Xiaowei Li, Yang Wang, Stefan Schwarz, Jianzhong Shen, Xi Xia   +5 more
doaj   +2 more sources

Coexistence of the Oxazolidinone Resistance–Associated Genes cfr and optrA in Enterococcus faecalis From a Healthy Piglet in Brazil [PDF]

Frontiers in Public Health, 2020
Oxazolidinones are one of the most important antimicrobials potentially active against glycopeptide- and β-lactam-resistant Gram-positive pathogens.
Lara M. Almeida, Lara M. Almeida, Anthony Gaca, Paulo M. Bispo, François Lebreton, Jose T. Saavedra, Rafael A. Silva, Irinaldo D. Basílio-Júnior, Felipe M. Zorzi, Pedro H. Filsner, Andrea M. Moreno, Michael S. Gilmore   +11 more
doaj   +3 more sources

Prevalence and genetic characterization of Gram-positive bacteria carrying linezolid resistance genes in vegetables [PDF]

Environmental Microbiome
Background Linezolid resistance poses an ecological threat to the health of humans, animals, and the environment. Vegetable may serve as reservoirs for resistance genes, yet its prevalence remain underexplored.
Yinglin Xu, Weiyi Shen, Kaiqi Zeng, Rong Zhang, Jiachang Cai   +4 more
doaj   +2 more sources

Complete genome sequence of optrA-carrying Enterococcus faecalis isolated from open pus in a Japanese patient

Journal of Global Antimicrobial Resistance, 2023
: Objectives: The occurrence of linezolid resistance in enterococci has recently increased. Here, we report the genomic characterization of Enterococcus faecalis strain JARB-HU0796—isolated from the open pus of a patient in Hiroshima, Japan—which shows ...
Takaya Segawa, Junzo Hisatsune, Kasumi Ishida-Kuroki, Yo Sugawara, Kanako Masuda, Kayoko Tadera, Seiya Kashiyama, Michiya Yokozaki, Mi Nguyen-Tra Le, Miki Kawada-Matsuo, Hiroki Ohge, Hitoshi Komatsuzawa, Motoyuki Sugai   +12 more
doaj   +2 more sources

[National surveillance of clinical isolates of Enterococcus faecalis resistant to linezolid carrying the optrA gene in Colombia, 2014-2019]. [PDF]

Revista panamericana de salud publica = Pan American journal of public health, 2020
To describe the epidemiological, phenotypical and genetic characteristics of clinical isolates carrying the optrA gene identified in antimicrobial resistance surveillance by the laboratory of the National Institute of Health of Colombia.Between October 2014 and February 2019, 25 isolates of Enterococcus spp.
Sandra Yamile, Saavedra, Johan Fabian, Bernal, Efrain, Montilla-Escudero, German, Torres, Mabel Karina, Rodríguez, Andrea Melissa, Hidalgo, María Victoria, Ovalle, Sandra, Rivera, Enrique, Perez-Gutierrez, Carolina, Duarte   +9 more
openaire   +3 more sources

Genomic insights into the global dissemination of linezolid resistance genes in Enterococcus faecium [PDF]

Frontiers in Microbiology
BackgroundTransferable linezolid resistance determinants in Enterococcus faecium, particularly optrA, poxtA, and cfr, have raised increasing global concern due to their potential dissemination across clinical, animal, food, and environmental reservoirs ...
Xiaoxiao Yuan, Chao Ma, Xiaoli Cao, Zhiwei Ma, Liuli Wu, Peitao Jiang, Zhengnan Yang   +6 more
doaj   +2 more sources

Emergence and Genomic Characterization of the First Reported optrA-Carrying Linezolid-Resistant Enterococci Isolated from Retail Broiler Meat in the United Arab Emirates

Foods, 2022
The foodborne transfer of resistant genes from enterococci to humans and their tolerance to several commonly used antimicrobials are of growing concern worldwide.
Ihab Habib, Akela Ghazawi, Glindya Bhagya Lakshmi, Mohamed-Yousif Ibrahim Mohamed, Dan Li, Mushtaq Khan, Shafi Sahibzada   +6 more
doaj   +2 more sources

Molecular Detection of Linezolid Resistance Determinants and Identification of a Novel C2626T Mutation in Clinical Isolates of Enterococcus Species from India [PDF]

Antibiotics
Background: Enterococcus species have emerged as significant multidrug-resistant nosocomial pathogens. Linezolid remains a vital last-resort therapeutic option for the management of severe infections caused by vancomycin-resistant Enterococci.
Madhumala Shanmugasundaram, MuthuLakshmi BackiaSubramanian, Shanthi Mariappan, Uma Sekar, Kennedy Kumar Palraj, Binesh Lal Yesudhason, Rhea Michelle J. Khodabux   +6 more
doaj   +2 more sources

Prevalence and molecular epidemiology of optrA-positive Enterococcus in herders and yaks from high-altitude Tibet, China

Journal of Global Antimicrobial Resistance
: Objectives: Antimicrobial resistance (AMR) in high-altitude environments remains understudied despite its growing global concern. This study investigates the molecular epidemiology of the optrA gene, which confers resistance to oxazolidinones and ...
Hanyu Wang, Xinyue Han, Aoxiao Chen, Zelin Yan, Rong Zhang, Yang Wang   +5 more
doaj   +2 more sources

Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China [PDF]

BMC Infectious Diseases
Background Immunocompromised cancer patients represent a susceptible population for enterococcal infections. While linezolid remains the primary therapeutic option for vancomycin-resistant Enterococcus (VRE) infections, the emergence of linezolid ...
Qun Wang, Xiaoyu Zhang, Weixing Wu, Zhenghua Xie, Yongping Lin, Li Zhang   +5 more
doaj   +2 more sources