Results 31 to 40 of about 1,674 (204)

Detection of optrA and poxtA genes in linezolid-resistant Enterococcus isolates from fur animals in China

Letters in Applied Microbiology, 2022
Abstract The emergence of linezolid-resistant (LR) enterococci found in food of animal origin arouses attention, but little is known about LR enterococci in fur animals. A total of 342 Enterococcus faecalis and 265 E. faecium strains isolated from fur animals in China from 2015 to 2017 were investigated to determine if LR enterococci ...
W. Sun, H. Liu, J. Liu, Q. Jiang, Y. Pan, Y. Yang, X. Zhu, J. Ge   +7 more
openaire   +2 more sources

Transferable Resistance Gene optrA in Enterococcus faecalis from Swine in Brazil

Antimicrobial Agents and Chemotherapy, 2020
OptrA is an ATP-binding cassette (ABC)-F protein that confers resistance to oxazolidinones and phenicols and can be either plasmid-encoded or chromosomally encoded. Here, we isolated 13 Enterococcus faecalis strains possessing a linezolid MIC of ≥4 mg/liter from nursery pigs in swine herds located across Brazil ...
Lara M. Almeida, François Lebreton, Anthony Gaca, Paulo M. Bispo, Jose T. Saavedra, Rodrigo N. Calumby, Luciano M. Grillo, Ticiano G. Nascimento, Pedro H. Filsner, Andrea M. Moreno, Michael S. Gilmore   +10 more
openaire   +3 more sources

Presence of optrA-mediated linezolid resistance in multiple lineages and plasmids of Enterococcus faecalis revealed by long read sequencing [PDF]

, 2022
Funding: This work was supported by the Chief Scientist Office (Scotland) through the Scottish Healthcare Associated Infection Prevention Institute (Reference SIRN/10). Bioinformatics and Computational Biology analyses were supported by the University of
El Sakka, Noha, Gillespie, Stephen H., Holden, Matthew T. G., Hopkins, Katie L., Karcher, Anne Marie, Khatamzas, Elham, McHugh, Martin P., Meunier, Danièle, Parcell, Benjamin J., Pettigrew, Kerry A., Templeton, Kate E., Toner, Geoff, Walker, Joanna, Weir, Robert, Woodford, Neil   +14 more
core   +5 more sources

Linezolid-resistant Enterococcus faecalis ST16 harbouring optrA on a Tn6674-like element isolated from surface water

Journal of Global Antimicrobial Resistance, 2021
: Objectives: The objective of this work was to characterise an optrA-carrying Enterococcus faecalis ST16 isolate recovered from a river water sample in Switzerland. Methods: Linezolid-resistant E.
Magdalena Nüesch-Inderbinen, Susanne Raschle, Marc J.A. Stevens, Kira Schmitt, Roger Stephan   +4 more
doaj   +1 more source

Molecular characteristics of optrA-carrying Enterococcus faecalis from chicken meat in South Korea

Poultry Science, 2020
The purpose of this study was to identify the genetic environment of optrA gene in linezolid (LZD)-resistant Enterococcus faecalis from chicken meat and to describe the probable mechanism of dissemination of the optrA gene through plasmid or chromosomal ...
Sunghyun Yoon, Se Hyun Son, Yeong Bin Kim, Kwang Won Seo, Young Ju Lee   +4 more
doaj   +1 more source

5-(carbamoylmethylene)-oxazolidin-2-ones as a promising class of heterocycles inducing apoptosis triggered by increased ROS levels and mitochondrial dysfunction in breast and cervical cancer [PDF]

, 2020
Oxazolidinones are antibiotics that inhibit protein synthesis by binding the 50S ribosomal subunit. Recently, numerous worldwide researches focused on their properties and possible involvement in cancer therapy have been conducted.
Armentano, B, Brindisi, M, Cappello, AR, Curcio, R, Dolce, V, Fiorillo, M, Frattaruolo, L, Gabriele, B, Mancuso, R, Rago, V, Ziccarelli, I   +10 more
core   +2 more sources

Genome characteristics of the optrA-positive Clostridium perfringens strain QHY-2 carrying a novel plasmid type

mSystems, 2023
Clostridium perfringens is a bacterial species of importance to both public and animal health. The gene optrA is the first gene that confers resistance to the tedizolid, a last-resort antimicrobial agent in human medicine.
Ke Wu, Zhe Li, Mingjin Fang, Yuan Yuan, Edward M. Fox, Yingqiu Liu, Ruichao Li, Li Bai, Wen Zhang, Wei-Min Zhang, Qi Yang, Lingling Chang, Pu Li, Xinglong Wang, Juan Wang, Zengqi Yang   +15 more
doaj   +1 more source

Rapid Identification of Species, Antimicrobial‐Resistance Genotypes and Phenotypes of Gram‐Positive Cocci Using Long Short‐Term Memory Raman Spectra Methods

Advanced Intelligent Systems, Volume 5, Issue 4, April 2023., 2023
Herein, a novel method that used artificial intelligence to analyze biological Raman spectra to identify microbes and their antimicrobial resistance at both genotype and phenotype levels is developed. The novel method exhibits higher level of accuracy than those obtained using the machine learning algorithms.
Jiayue Lu, Jifan Chen, Ling Huang, Siheng Wang, Yingbo Shen, Sheng Chen, Zhangqi Shen, Rong Zhang   +7 more
wiley   +1 more source

Analysis of two pheromone-responsive conjugative multiresistance plasmids carrying the novel mobile optrA locus from Enterococcus faecalis [PDF]

, 2019
Background: The acquired optrA gene, which encodes a ribosomal protection protein of the ABC-F family, can confer cross-resistance to linezolid and florfenicol, posing a serious therapeutic challenge to both human and veterinary medicine.
Chen, Yu-Xia, Du, Xiang-Dang, Li, Dexi, Ouyang, Wuqing, Schwarz, Stefan, Shan, Xinxin, Shang, Yanhong, Zhang, Su-Mei   +7 more
core   +1 more source

An in‐house 45‐plex array for the detection of antimicrobial resistance genes in Gram‐positive bacteria

MicrobiologyOpen, Volume 12, Issue 1, February 2023., 2023
Here we describe an in‐house bead array targeting antimicrobial resistance (AMR) genes of Gram‐positive bacteria and allowing their rapid detection all at once at reduced costs. A total of 27/41 AMR probes targeting genes frequently associated with resistance tested positive on a collection of 124 enterococci and 62 staphylococci isolated from healthy ...
Carole Kowalewicz, Michael Timmermans, David Fretin, Pierre Wattiau, Cécile Boland   +4 more
wiley   +1 more source