Results 1 to 10 of about 9,997,733 (366)

Home confinement’s impact on myopia control by using orthokeratology in school-aged children

BMC Ophthalmology, 2023
Background Home confinement during the epidemic has a significant impact on the lifestyle and behavior of school-aged children, who have exhibited an increase in the prevalence and development of myopia. Our research will look at if home confinement will
Boyuan Zhang, Hongfei Liao, Fen Xiong, Tian Mao, Lili Wu, Yue Li, Chao Xiong   +6 more
doaj   +1 more source

Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis

Cell Discovery, 2023
Targeting programmed cell death protein ligand 1 (PD-L1) remains one of the most essential immunotherapies in cancer1,2. PD-L1 has been detected in the nucleus in multiple malignancies, playing an oncogenic role independent of immune checkpoint ...
Jie Yu, Ai Zhuang, Xiang Gu, Yu Hua, Ludi Yang, Shengfang Ge, Jing Ruan, Peiwei Chai, Renbing Jia, Xianqun Fan   +9 more
doaj   +1 more source

A clinical study of topical treatment for thyroid-associated ophthalmopathy with dry eye syndrome

BMC Ophthalmology, 2023
Introduction Clinically, thyroid-associated ophthalmopathy (TAO) patients were suffered from dry eye syndrome. Only a few relevant studies were about this topic.
Rou Sun, Muyue Yang, Chenyi Lin, Yu Wu, Jing Sun, Huifang Zhou   +5 more
doaj   +1 more source

Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Genome Biology, 2021
Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization.
Jie Yu, Peiwei Chai, Minyue Xie, Shengfang Ge, Jing Ruan, Xianqun Fan, Renbing Jia   +6 more
doaj   +1 more source

Effects of miR-672 on the angiogenesis of adipose-derived mesenchymal stem cells during bone regeneration

Stem Cell Research & Therapy, 2021
Background Sufficient vascular network plays an important role in the repair of bone defects. Bone morphogenetic protein 2 (BMP2) being a key regulator of angiogenesis has attracted the attention of researchers.
Mingjiao Chen, Meng Zhou, Yao Fu, Jin Li, Zi Wang   +4 more
doaj   +1 more source

Retrospective Case Analysis of Transnasal Endoscopic Resection of Benign Orbital Apex Tumors: Some Thoughts on Transnasal Endoscopic Surgery

Journal of Ophthalmology, 2021
Purpose. To deeply discuss the patient selection, surgical planning, surgical techniques, and the therapeutic challenge for endoscopic transnasal resection of benign orbital apex tumors (OATs). Methods.
Cheng Li, Yang Gao, Rongxin Chen, Chao Cheng, Pan Yin, Zhihui Zhang, Yinghao Wang, Yuekun Bao, Huan Ma, Jianbo Shi, Rong Lu   +10 more
doaj   +1 more source

Functional Studies of Novel FOXL2 Variants in Chinese Families With Blepharophimosis–Ptosis–Epicanthus Inversus Syndrome

Frontiers in Genetics, 2021
The blepharophimosis–ptosis–epicanthus inversus syndrome (BPES) is a rare autosomal dominant disease mainly caused by FOXL2 variants. This genetic disorder is usually characterized by eyelid malformation and ovarian dysfunction.
Fang Li, Fang Li, Huifang Chen, Huifang Chen, Yefei Wang, Yefei Wang, Jie Yang, Jie Yang, Yixiong Zhou, Yixiong Zhou, Xin Song, Xin Song, Jiayan Fan, Jiayan Fan   +13 more
doaj   +1 more source

Management of Unsatisfactory Postoperative Double Eyelid With Intralesional Corticosteroid Injection

Frontiers in Medicine, 2021
Purpose: The present study was designed to observe the curative effect of early intralesional corticosteroid injection to treat unsatisfactory double eyelid.Methods: This retrospective, observational study included 30 female patients (age 22–35 years ...
Siyi Zhang, Siyi Zhang, Yixiong Zhou, Yixiong Zhou, Fei Yu, Fei Yu, Dan Yan, Dan Yan, Yan Yan, Yan Yan, Meng Zhou, Meng Zhou, Yao Fu, Yao Fu, Yang Lu, Yang Lu   +15 more
doaj   +1 more source

Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification

Journal of Experimental & Clinical Cancer Research, 2022
Metabolites are intermediate products of cellular metabolism catalysed by various enzymes. Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal metabolite accumulation.
Yidian Fu, Jie Yu, Fang Li, Shengfang Ge
doaj   +1 more source

Sperm-Specific Glycolysis Enzyme Glyceraldehyde-3-Phosphate Dehydrogenase Regulated by Transcription Factor SOX10 to Promote Uveal Melanoma Tumorigenesis

Frontiers in Cell and Developmental Biology, 2021
Melanoma cells exhibit increased aerobic glycolysis, which represents a major biochemical alteration associated with malignant transformation; thus, glycolytic enzymes could be exploited to selectively target cancer cells in cancer therapy.
Xia Ding, Xia Ding, Lihua Wang, Lihua Wang, Mingjiao Chen, Mingjiao Chen, Yue Wu, Yue Wu, Shengfang Ge, Shengfang Ge, Jin Li, Jin Li, Xianqun Fan, Xianqun Fan, Ming Lin, Ming Lin   +15 more
doaj   +1 more source