Results 111 to 120 of about 17,610 (263)

Comparative effects of hypnotic agents on sleep architecture and respiratory outcomes in obstructive sleep apnea: A systematic review and network meta‐analysis

Psychiatry and Clinical Neurosciences, EarlyView.
Aim This network meta‐analysis of randomized controlled trials (RCTs) aimed to investigate which hypnotics are associated with the most favorable sleep architecture and respiratory outcomes in adults with obstructive sleep apnea. Methods Primary outcomes included total sleep time (TST) and apnea–hypopnea index (AHI) during TST.
Taro Kishi, Toshikazu Ikuta, Kenji Sakuma, Masakazu Hatano, Tatsuhiko Kishi, Tsuyoshi Kitajima, Nakao Iwata   +6 more
wiley   +1 more source

Differential Roles of Each Orexin Receptor Signaling in Obesity

iScience, 2019
Summary: Orexins are hypothalamic neuropeptides that regulate feeding, energy expenditure, and sleep. Although orexin-deficient mice are susceptible to obesity, little is known about the roles of the orexin receptors in long-term energy metabolism. Here,
Miyo Kakizaki, Yousuke Tsuneoka, Kenkichi Takase, Staci J. Kim, Jinhwan Choi, Aya Ikkyu, Manabu Abe, Kenji Sakimura, Masashi Yanagisawa, Hiromasa Funato   +9 more
doaj   +1 more source

Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors. [PDF]

, 2014
Diurnal release of the orexin neuropeptides orexin-A (Ox-A, hypocretin-1) and orexin-B (Ox-B, hypocretin-2) stabilises arousal, regulates energy homeostasis and contributes to cognition and learning.
Longordo, F., Lüthi, A., Massonnet, C., Perin, M., Welker, E.   +4 more
core   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

Sex‐specific impact of repeated adolescent vapour exposure to JWH‐018 on dopamine response, behaviour and pharmacokinetics across adolescence and adulthood

British Journal of Pharmacology, Volume 183, Issue 7, Page 1517-1538, April 2026.
Abstract Background and Purpose Alarming trends show that vaping e‐cigarettes containing synthetic cannabinoid receptor agonists, such as JWH‐018, is increasing among youth. However, the effects of these trends are unclear in both sexes. We therefore characterized the neuropharmacological effects of adolescent JWH‐018 inhalation in male and female rats.
Nicholas Pintori, Cristina Manis, Enrica Spano, Nicola Simola, Alessandro Ieraci, Pierluigi Caboni, Gaetano Di Chiara, Maria Antonietta De Luca   +7 more
wiley   +1 more source

Age-related central regulation of orexin and NPY in the short-lived African killifish Nothobranchius furzeri [PDF]

, 2019
Orexin A (OXA) and neuropeptide Y (NPY) are two hypothalamic neuropeptides involved in the regulation of feeding behavior and food intake in all vertebrates.
Avallone, Luigi, Baumgart, Mario, Castaldo, Luciana, Cellerino, Alessandro, D'Angelo, Livia, de Girolamo, Paolo, Lucini, Carla, Montesano, Alessia, Tozzini, Eva Terzibasi   +8 more
core   +1 more source

The Association Between Disordered Eating and Sleep in Non‐Clinical Populations—A Systematic Review and Meta‐Analysis

Journal of Sleep Research, Volume 35, Issue 2, April 2026.
ABSTRACT Sleep and disordered eating behaviours may be linked through physiological and psychological mechanisms; yet, no review has systematically investigated the relationship between different sleep indicators and disordered eating behaviours and cognitions outside a clinical context.
Marie‐Christine Opitz, Nora Trompeter, Francisco Diego Rabelo‐da‐Ponte, Michelle Carroll, Kyle Buchan, Giulia Gaggioni, Sarah Moody, Sylvane Desrivières, Nadia Micali, Ulrike Schmidt, Helen Sharpe, EDIFY Consortium, Ulrike Schmidt, Helen Sharpe, Karina Allen, Heike Bartel, Iain Campbell, Sylvane Desrivières, Richard Dobson, Amos Folarin, Tara French, John Kelly, Umairah Malik, Nadia Micali, Sneha Raman, Zulqarnain Rashid, Janet Treasure, Callum Bryson, Daire Douglas, Amelia Hemmings, Başak İnce Çağlar, Carina Kuehne, Sarah Moody, Marie‐Christine Opitz, Tamsin Parnell, Fiona Stephens, Nora Trompeter, Jessica Wilkins, Alice Bromell, Grace Davis, Cameron Eadie, Beck Heslop, Isabella Malvisi, Katie Mckenzie, Emma Scott, Chris Sims, Tallulah Street, Andreia Tavares‐Semedo, Eleanor Wilkinson, Lucz Zocek   +49 more
wiley   +1 more source

One Single Session to Sleep Them All? The Potential of Single‐Session Interventions for Insomnia

Journal of Sleep Research, Volume 35, Issue 2, April 2026.
ABSTRACT Poor sleep and insomnia are pervasive public health concerns, with insomnia ranking as the second most prevalent mental health disorder in the general population. Moreover, insomnia is a significant predictor of subsequent depression and is frequently co‐occurring with other psychological difficulties.
Matteo Carpi, Erica Marie Szkody, Daniel Ruivo Marques   +2 more
wiley   +1 more source

Differential roles of orexin receptors in the regulation of sleep/wakefulness

Frontiers in Endocrinology, 2013
Orexin A and orexin B are hypothalamic neuropeptides that play critical roles in the regulation of sleep/wakefulness, as well as in a variety of physiological functions such as emotion, reward, and energy homeostasis.
Michihiro eMieda, Natsuko eTsujino, Takeshi eSakurai   +2 more
doaj   +1 more source