Results 71 to 80 of about 17,610 (263)
Orexin in the chicken hypothalamus: immunocytochemical localisation and comparison of mRNA concentrations during the day and night, and after chronic food restriction [PDF]
, 2013 In mammals Orexin-A and -B are neuropeptides involved in the hypothalamic regulation of diverse physiological functions including food intake and the sleep-wake cycle.
de Girolamo, Paolo +5 more
core +1 more source
Advancing pharmacometrics in Africa—Transition from capacity development toward job creation
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai +10 more
wiley +1 more source
ラット脳室内へのオレキシン-A持続投与は明期の摂食量を増加させたが、体重増加には影響はなかった [PDF]
, 2000 Orexins(orexin-A and -B)are recently identified neuropeptides,which are thought to be implicated in the regulation of feeding behavior. We used a NPY-Y1 receptor specific antagonist,BIBO3304,to examine whether NPY is involved in orexin-induced feeding ...
Yamanaka Akihiro, 山中 章弘
core
Phytotherapy Research, EarlyView.Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli +4 more
wiley +1 more source
Orexin, Orexin Receptor Antagonists and Central Cardiovascular Control
Frontiers in Neuroscience, 2013 Orexin makes an important contribution to the regulation of cardiovascular function. When injected centrally under anesthesia, orexin increases blood pressure, heart rate and sympathetic nerve activity.
Pascal eCarrive
doaj +1 more source
Localization of orexin B and orexin-2 receptor in the rat epididymis [PDF]
, 2018 The peptides orexin A (OXA) and orexin B (OXB) derived from the proteolytic cleavage of a common precursor molecule, prepro-orexin, were originally described in the rat hypothalamus.
Alfredo Vittoria +8 more
core +1 more source
Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signaling [PDF]
, 2017 In the hypothalamic arcuate nucleus (ARC), proopiomelanocortin (POMC) neurons and the POMC-derived peptide α–melanocytestimulating hormone (α-MSH) promote satiety. POMC neurons receive orexin-A (OX-A)-expressing inputs and express both OX-A receptor type
Buono, Lorena +2 more
core +1 more source
Acta Crystallographica Section C, EarlyView.X‐ray crystallography revealed that the reaction of 2‐{[4‐(4‐bromophenyl)‐1H‐1,2,3‐triazol‐1‐yl]methyl}phthalimide with morpholine led to substitution of the phthalimide group, including migration of the substituent from N1 to N2 on the 1,2,3‐triazole ring.2‐{[4‐(4‐Bromophenyl)‐1H‐1,2,3‐triazol‐1‐yl]methyl}phthalimide, C17H11BrN4O, was synthesized by ...
Paul R. Palme +5 more
wiley +1 more source
Orphanet Journal of Rare Diseases, 2020 Study objectives Niemann-Pick type C (NPC) is an autosomal recessive and congenital neurological disorder characterized by the accumulation of cholesterol and glycosphingolipids.
A. Imanishi +13 more
doaj +1 more source
Phase II Proof-of-Concept Trial of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Major Depressive Disorder. [PDF]
, 2017 BackgroundWe evaluated the orexin receptor antagonist filorexant (MK-6096) for treatment augmentation in patients with major depressive disorder.MethodsWe conducted a 6-week, double-blind, placebo-controlled, parallel-group, Phase II, proof-of-concept ...
Ceesay, Paulette +9 more
core +1 more source